Results 1 to 10 of about 31,677 (161)

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor [PDF]

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +2 more sources

Small molecule allosteric modulation of the adenosine A1 receptor [PDF]

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs) represent the target for approximately a third of FDA-approved small molecule drugs. The adenosine A1 receptor (A1R), one of four adenosine GPCR subtypes, has important (patho)physiological roles in humans.
Anh T. N. Nguyen, Quan L. Tran, Jo-Anne Baltos, Samantha M. McNeill, Diep T. N. Nguyen, Lauren T. May   +5 more
doaj   +2 more sources

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons [PDF]

Neural Regeneration Research, 2020
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.
Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun, Francisco S Cayabyab   +9 more
doaj   +2 more sources

Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats [PDF]

Frontiers in Pharmacology, 2019
Objective: The adenosinergic system may influence excitability in the brain. Endogenous and exogenous adenosine has anticonvulsant activity presumably by activating A1 receptors.
Petr Fabera, Petr Fabera, Martina Parizkova, Martina Parizkova, Libor Uttl, Libor Uttl, Katerina Vondrakova, Katerina Vondrakova, Hana Kubova, Grygoriy Tsenov, Grygoriy Tsenov, Pavel Mares   +11 more
doaj   +2 more sources

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Multisite Model of Allosterism for the Adenosine A1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2020
ABSTRACT Despite being a target for about one-third of approved drugs, G protein-coupled receptors (GPCRs) still represent a tremendous reservoir for therapeutic strategies against countless diseases. For example, several cardiovascular and central nervous systems conditions could benefit from clinical agents that ...
Giuseppe Deganutti, Kerry Barkan, Graham Ladds, Christopher A. Reynolds   +3 more
openaire   +2 more sources

Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially Through the Adenosine A1 Receptor

Natural Product Communications, 2022
Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in an animal model.
Kazuya Kusama, Takumi Suzuki, Ryosuke Motohashi, Takumi Nobusawa, Koichiro Ota, Mana Azumi, Mikihiro Yoshie, Hiroaki Miyaoka, Kazuhiro Tamura   +8 more
doaj   +1 more source

A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain

NeuroImage, 2023
The EEG alpha rhythm (∼ 8–13 Hz) is one of the most salient human brain activity rhythms, modulated by the level of attention and vigilance and related to cerebral energy metabolism.
Naemi L. Tichelman, Anna L. Foerges, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Andreas Bauer, Hans-Peter Landolt, Daniel Aeschbach, David Elmenhorst   +12 more
doaj   +1 more source

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]

Journal of Histochemistry & Cytochemistry, 2000
The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
MINELLI, Alba, ALLEGRUCCI, Cinzia, Piomboni P., MANNUCCI, Roberta, Lluis C., Franco R.   +5 more
openaire   +4 more sources

Influence of adenosine receptor ligands on ketamine-induced anesthesia in mice

Current Issues in Pharmacy and Medical Sciences, 2012
The influence of adenosine receptor ligands on anesthetic activity of  ketamine was studied in mice. Ketamine-induced anesthesia (100 mg/kg) was significantly increased by the  higher doses of CPA (selective A1 adenosine receptor agonist) and NECA (A1 ...
Sylwia Fidecka, Marcin Mandryk
doaj   +1 more source