Results 41 to 50 of about 189,720 (274)

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Adenosine Triphosphatase Activity of Tritrichomonas foetus [PDF]

Journal of General Microbiology, 1979
Homogenates of Tritrichomonas foetus exhibited a Mg2+-dependent adenosine triphosphatase (ATPase) activity, with a pH optimum in Tris buffers of 8.2 to 8.3. The activity was not sensitive to oxygen. At high concentrations, quercetin and 4-chloro-7-nitrobenzofurazan inhibited ATPase activity in the cytoplasmic extract by 20 and 70%, respectively ...
D, Lloyd, D G, Lindmark, M, Müller
openaire   +2 more sources

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source

Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory StimuliSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis.
Wei Ye, Hidehiko Takabayashi, Yitian Yang, Maria Mao, Elise S. Hibdon, Linda C. Samuelson, Kathryn A. Eaton, Andrea Todisco   +7 more
doaj   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

The epigallocatechin gallate derivative Y6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo

Acta Pharmaceutica Sinica B, 2019
Previously, we reported that Y6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin (DOX)--mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells.
Yan Wen, Ruiqiang Zhao, Pranav Gupta, Yingfang Fan, Yunkai Zhang, Zhenguang Huang, Xiaohui Li, Yuangang Su, Lijuan Liao, Yu-An Xie, Donghua Yang, Zhe-Sheng Chen, Gang Liang   +12 more
doaj   +1 more source

Multiple Periapical Lesions Influence the Expression of TLR4/NF‐κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol‐Consuming Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate the impact of multiple apical periodontitis (AP) on the expression of TLR4/NF‐κB pathway components, proinflammatory cytokine levels, and development of hepatic injuries in rats with and without chronic alcohol consumption. Methodology Thirty‐two rats were assigned to four groups (n = 8): Control, AP, Alcohol, and Alcohol+AP ...
Karem Paula Pinto, Isabelle da Cunha Degani, Jenif Braga de Souza, Renata Heisler Neves, Luciana Brandão‐Bezerra, Luciana Moura Sassone, Emmanuel João Nogueira Leal da Silva   +6 more
wiley   +1 more source

Histology and histochemistry of the venom apparatus of the black scorpion Androctonus crassicauda (Olivier, 1807) (Scorpiones: Buthidae)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
The venom apparatus of the black scorpion Androctonus crassicauda has been characterized histologically and histochemically in the present study. The results showed that this apparatus consists of paired venom glands, each of which initially presents its
BM Jarrar, MA Al-Rowaily
doaj   +1 more source

Luteodorsum huanglongense (Gomphaceae, Gomphales), a New Genus and Species of Gomphoid Fungus from the Loess Plateau, Northwest China

Journal of Fungi, 2023
During an investigation of the macrofungal flora in the Huanglong Mountains of the Loess Plateau, northwest China, a unique gomphoid fungus was discovered and collected.
Zijia Peng, Yiming Wu, Zeyu Luo, Chaowei Xiong, Xiaoyong Liu, Bin Wang, Baoyou Ma, Jianxian Wei, Zhongdong Yu   +8 more
doaj   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source