Results 1 to 10 of about 29,310 (202)

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications [PDF]

Experimental Physiology
Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways.
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
doaj   +3 more sources

Ouabain – a double-edged sword in tumor development and progression? a review of half a century [PDF]

Frontiers in Physiology
Since their first discovery as potential anti-cancer drugs there is increasing evidence that cardiotonic steroids e.g., Ouabain have anti-tumor properties by interacting with their natural receptor the Na+-K+-ATPase (NKA) and by inducing diverse ...
Heidrun Weidemann, Alaa Daoud Sarsour, Alaa Daoud Sarsour, Chaya Brodie, Chaya Brodie   +4 more
doaj   +2 more sources

Neuroprotective Effects of Strength Training on Behavioral Deficit, Oxidative Damage, Astrogliosis, and Neuronal Death in a Bipolar Disorder Model. [PDF]

J Neurochem
Schematic representation of the neuroprotective effects of strength training in an ouabain‐induced model of bipolar disorder. The intracerebroventricular injection of ouabain induces behavioral alterations (manic‐ and depressive‐like behaviors and cognitive deficits), increases oxidative stress (↑reactive species, ↓antioxidant defenses), promotes ...
Maidana LM, da Silva Guerra JM, Souza-Pereira A, Dahleh MMM, Godinho DB, Prigol M, Royes LFF, Rambo LM.   +7 more
europepmc   +2 more sources

Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP [PDF]

Biomolecules
Cardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function.
Yulia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov   +2 more
doaj   +2 more sources

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization [PDF]

Frontiers in Immunology
IntroductionMycobacterium abscessus (M. abscessus) is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its ...
Nan Li, Nan Li, Nan Li, Songqiang Huang, Songqiang Huang, Xing Shi, Kuo Lu, Kuo Lu, Xiu Yu, Chen Qiu, Rongchang Chen   +10 more
doaj   +2 more sources

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation. [PDF]

Mol Ecol Resour
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Kim S, Farrell BD.
europepmc   +2 more sources

The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron [PDF]

, 2012
In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Feng, Jianfeng, Forrest, Michael D., Press, Daniel A., Wall, Mark J.   +3 more
core   +14 more sources

Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.

PLoS ONE, 2023
Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr, Tobias Kiesslich, Dino Bekric, Marlena Beyreis, Michael Kittl, Celina Ablinger, Elen Neureiter, Martin Pichler, Felix Prinz, Markus Ritter, Daniel Neureiter, Martin Jakab, Heidemarie Dobias   +12 more
doaj   +2 more sources

Ouabain Induces Transcript Changes and Activation of RhoA/ROCK Signaling in Cultured Epithelial Cells (MDCK)

Current Issues in Molecular Biology, 2023
Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón, Lorena Hinojosa, Beatriz Xoconostle-Cázares, José Abrahán Ramírez-Pool, Aída Castillo, Marcelino Cereijido, Arturo Ponce   +6 more
doaj   +1 more source

Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3

Frontiers in Oncology, 2021
Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du, Jie Du, Lijun Jiang, Fuqiang Chen, Huantao Hu, Meijuan Zhou   +5 more
doaj   +1 more source