Results 1 to 10 of about 22,704 (219)
Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice [PDF]
Mediators of Inflammation, 2011 Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos +7 more
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Ouabain Increases Gap Junctional Communication in Epithelial Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce +8 more
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The Influence of Ouabain on Human Dendritic Cells Maturation
Mediators of Inflammation, 2014 Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation ...
C. R. Nascimento +6 more
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Hypertensive effects of the iv administration of picomoles of ouabain
Brazilian Journal of Medical and Biological Research, 2011 Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and
A.S. Padilha +4 more
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Journal of Pharmacological Sciences, 2007 Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka +5 more
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Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]
PLoS ONE, 2013 Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun +5 more
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Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Biomedicines, 2022 Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain.
Paula Fernanda Kinoshita +7 more
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Discover Oncology, 2023 Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance.
Heidrun Weidemann +4 more
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Ouabain enhances ADPKD cell apoptosis via the intrinsic pathway
Frontiers in Physiology, 2016 Progression of autosomal dominant polycystic kidney disease (ADPKD) is highly influenced by factors circulating in blood. We have shown that the hormone ouabain enhances several characteristics of the ADPKD cystic phenotype, including the rate of cell ...
Gustavo eBlanco, Jessica eVenugopal
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THE EFFECT OF LITHIUM ON THE INOTROPIC EFFECT OF OUABAIN AND MANIFESTATION OF ARRHYTHMIA IN GUINEA-PIG ATRIA [PDF]
Acta Medica Iranica, 1995 rli....xposure ofthe guinea-pig whole a/ria to lithium (1 and 5 mM) produced a reduction ofinotropic response to ouubain. The inhibitory effect oflithium (1 m"f) was slight, whereas lithium (5 mM) significantly reduced tlze response oj the preparations ...
Ahmad Reza Dehpour +3 more
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