Ouabain - a double-edged sword in tumor development and progression? a review of half a century. [PDF]
Front PhysiolSince their first discovery as potential anti-cancer drugs there is increasing evidence that cardiotonic steroids e.g., Ouabain have anti-tumor properties by interacting with their natural receptor the Na+-K+-ATPase (NKA) and by inducing diverse ...
Weidemann H, Sarsour AD, Brodie C.
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Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP. [PDF]
BiomoleculesCardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function.
Stepanenko YD, Sibarov DA, Antonov SM.
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Ouabain alleviates <i>Mycobacterium abscessus</i>-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization. [PDF]
Front ImmunolIntroductionMycobacterium abscessus (M. abscessus) is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its ...
Li N +6 more
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Ouabain-induced hypertension in rats: Mechanisms, variability and translational implications. [PDF]
Exp PhysiolOuabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways.
Feijó PRO, Quintas LEM.
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Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.
PLoS ONE, 2023 Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr +12 more
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Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
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Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
Frontiers in Oncology, 2021 Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du +5 more
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Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
Frontiers in Physiology, 2017 Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Luiz H. A. Cavalcante-Silva +9 more
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Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
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Brazilian Journal of Medical and Biological Research, 2001 Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and 18 µg/kg, and 1.8 mg/kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 µg, in bolus)-evoked pressor responses were ...
L.V. Rossoni, V.D. Pinto, D.V. Vassallo
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