Results 21 to 30 of about 22,704 (219)
Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
doaj +1 more source
Radioimmunoassays, Ouabain-Like Material, and Ouabain [PDF]
Hypertension, 2005 To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved without ...
P.J. Hilton, W. McKinnon
openaire +1 more source
Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
Frontiers in Oncology, 2021 Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du +5 more
doaj +1 more source
Ouabain and Serum Sodium [PDF]
Hypertension, 2005 To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by ≈3 mmol/L.1 Conversely, a progressive increase in salt intake ...
Gasowski, Jerzy +3 more
openaire +2 more sources
Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2001 Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and 18 µg/kg, and 1.8 mg/kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 µg, in bolus)-evoked pressor responses were ...
L.V. Rossoni, V.D. Pinto, D.V. Vassallo
doaj +1 more source
Wistar rats resistant to the hypertensive effects of ouabain exhibit enhanced cardiac vagal activity and elevated plasma levels of calcitonin gene-related peptide. [PDF]
PLoS ONE, 2014 Ouabain is a cardiac glycoside produced in the adrenal glands and hypothalamus. It affects the function of all cells by binding to Na+/K+-ATPase. Several lines of evidence suggest that endogenous ouabain could be involved in the pathogenesis of essential
Elham Ghadhanfar +2 more
doaj +1 more source
On the structure of endogenous ouabain [PDF]
Proceedings of the National Academy of Sciences, 1999 The ouabain-like sodium pump inhibitor in mammals (so-called “endogenous ouabain”) has been considered a subtle structural isomer of ouabain. Its structural investigation, however, has long been hindered by the paucity of sample material.
A, Kawamura +9 more
openaire +2 more sources
Is ouabain produced by the adrenal gland? [PDF]
, 1998 Ouabain or a related stereoisomer, termed endogenous ouabain, has been identified in adrenal cortex tissue and culture medium from adrenocortical cells.Angiotensin II and adrenocorticotropin, the main activators of aldosterone secretion from adrenal ...
Prat Martorell, Hernán +5 more
core +1 more source
Radioiodinated Tyrosyl-Ouabain and Measurement of a Circulating Ouabain-like Compound [PDF]
Clinical Chemistry, 2001 Abstract Background: Assays for endogenous ouabain, a cardiac glycoside believed to be involved in blood pressure and volume regulation, are characterized by laboratory-specific plasma values that are measured by different assays. Because of this variability, our study focused on the development of a new 125I-labeled ouabain derivative ...
O, Vakkuri +5 more
openaire +2 more sources