Results 21 to 30 of about 13,484 (179)
Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]
PLoS ONE, 2013 Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun +5 more
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Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice
Mediators of Inflammation, 2011 Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos +7 more
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Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Biomedicines, 2022 Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain.
Paula Fernanda Kinoshita +7 more
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Discover Oncology, 2023 Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance.
Heidrun Weidemann +4 more
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Neuroinflammation and Neutrophils: Modulation by Ouabain [PDF]
Frontiers in Pharmacology, 2022 Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration ...
Jacqueline Alves Leite +5 more
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Ouabain enhances ADPKD cell apoptosis via the intrinsic pathway
Frontiers in Physiology, 2016 Progression of autosomal dominant polycystic kidney disease (ADPKD) is highly influenced by factors circulating in blood. We have shown that the hormone ouabain enhances several characteristics of the ADPKD cystic phenotype, including the rate of cell ...
Gustavo eBlanco, Jessica eVenugopal
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Radioiodinated Tyrosyl-Ouabain and Measurement of a Circulating Ouabain-like Compound [PDF]
Clinical Chemistry, 2001 Abstract Background: Assays for endogenous ouabain, a cardiac glycoside believed to be involved in blood pressure and volume regulation, are characterized by laboratory-specific plasma values that are measured by different assays. Because of this variability, our study focused on the development of a new 125I-labeled ouabain derivative ...
O, Vakkuri +5 more
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THE EFFECT OF LITHIUM ON THE INOTROPIC EFFECT OF OUABAIN AND MANIFESTATION OF ARRHYTHMIA IN GUINEA-PIG ATRIA [PDF]
Acta Medica Iranica, 1995 rli....xposure ofthe guinea-pig whole a/ria to lithium (1 and 5 mM) produced a reduction ofinotropic response to ouubain. The inhibitory effect oflithium (1 m"f) was slight, whereas lithium (5 mM) significantly reduced tlze response oj the preparations ...
Ahmad Reza Dehpour +3 more
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Frontiers in Physiology, 2020 The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer +13 more
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Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]
PLoS ONE, 2017 Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou +3 more
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