Ouabain – a double-edged sword in tumor development and progression? a review of half a century [PDF]
Frontiers in PhysiologySince their first discovery as potential anti-cancer drugs there is increasing evidence that cardiotonic steroids e.g., Ouabain have anti-tumor properties by interacting with their natural receptor the Na+-K+-ATPase (NKA) and by inducing diverse ...
Heidrun Weidemann +4 more
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Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain
Frontiers in Physiology, 2017 Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Luiz Henrique Agra Cavalcante‑Silva +2 more
exaly +3 more sources
Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP [PDF]
BiomoleculesCardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function.
Yulia D. Stepanenko +2 more
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Effects of ouabain on vascular reactivity [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity.
Vassallo D.V. +3 more
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Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization [PDF]
Frontiers in ImmunologyIntroductionMycobacterium abscessus (M. abscessus) is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its ...
Nan Li +10 more
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Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications [PDF]
Experimental PhysiologyOuabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways.
Priscilla Rodrigues O. Feijó +1 more
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Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.
PLoS ONE, 2023 Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr +12 more
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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron [PDF]
, 2012 In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Feng, Jianfeng +3 more
core +10 more sources
Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
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Radioimmunoassays, Ouabain-Like Material, and Ouabain [PDF]
Hypertension, 2005 To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved without ...
P.J. Hilton, W. McKinnon
openaire +1 more source