Results 11 to 20 of about 22,704 (219)

Effects of ouabain on vascular reactivity [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity.
Vassallo D.V., E. Songu-Mize, L.V. Rossoni, S.M.C. Amaral   +3 more
doaj   +5 more sources

Much More Than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

Frontiers in Physiology, 2017
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Deyse C M Carvalho, Luiz Henrique Agra Cavalcante Silva, Sandra Rodrigues-Mascarenhas   +2 more
exaly   +3 more sources

Ouabain – a double-edged sword in tumor development and progression? a review of half a century [PDF]

Frontiers in Physiology
Since their first discovery as potential anti-cancer drugs there is increasing evidence that cardiotonic steroids e.g., Ouabain have anti-tumor properties by interacting with their natural receptor the Na+-K+-ATPase (NKA) and by inducing diverse ...
Heidrun Weidemann, Alaa Daoud Sarsour, Alaa Daoud Sarsour, Chaya Brodie, Chaya Brodie   +4 more
doaj   +2 more sources

Ouabain Relieves Sleep Deprivation–Induced Anxiety‐Like Behavior in Mice by Suppressing Hippocampal Neuroinflammation and Oxidative Stress [PDF]

Brain and Behavior
Background: Sleep insufficiency has become a global public health challenge and is closely associated with the onset of mood and anxiety disorders.
Hanxiao Zhu, Wei Wang
doaj   +2 more sources

Erythrocyte sodium pump stimulation by ouabain and an endogenous ouabain‐like factor

Cell Biochemistry and Function, 2006
AbstractCardiac glycosides inhibit the sodium pump. However, some studies suggest that nanomolar ouabain concentrations can stimulate the activity of the sodium pump.In this study, using the Na+/K+‐ATPase of human erythrocytes, we compared the effect of digoxin, ouabain and an ouabain like‐factor (OLF), on 86Rb uptake.Ouabain concentrations below 10−9 ...
Balzan S, D'Urso G, Nicolini G, Forini F, Pellegrino M, Montali U   +5 more
openaire   +4 more sources

Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP [PDF]

Biomolecules
Cardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function.
Yulia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov   +2 more
doaj   +2 more sources

Microinjection of ouabain into crab single muscle fibers and the mechanism of ouabain potentiation

Canadian Journal of Physiology and Pharmacology, 1980
In order to clarify the mechanism of the potentiating effect of ouabain on contraction, a study was made of the effect of microinjection of 1.5 μL of ouabain on contractile responses and 22Na efflux, using single muscle fibers of crab (i–iii), and the results obtained were compared with observations (iv) on frog hearts.
S, Fujino, M, Fujino
openaire   +3 more sources

Studies on the cardiotoxicity of ouabain

Canadian Journal of Physiology and Pharmacology, 1969
Pretreatment with reserpine in a catecholamine-depleting dosage schedule greatly increased the arrhythmic and lethal dose of ouabain in cats. Pretreatment with reserpine immediately before the administration of ouabain also increased these doses significantly but the effect was less marked than that produced by 24-h pretreatment.
A K, Reynolds, M L, Horne
openaire   +3 more sources

Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.

PLoS ONE, 2023
Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr, Tobias Kiesslich, Dino Bekric, Marlena Beyreis, Michael Kittl, Celina Ablinger, Elen Neureiter, Martin Pichler, Felix Prinz, Markus Ritter, Daniel Neureiter, Martin Jakab, Heidemarie Dobias   +12 more
doaj   +2 more sources

Partial hearing recovery after cochlear nerve surface transplantation of hair follicle-derived neural crest stem cells in neural hearing loss rat. [PDF]

Animal Model Exp Med
This study comprises three experimental parts. Part 1. Time‐course of ouabain‐induced hearing loss. Rats received ouabain (10 mM) via round window application. ABR/DPOAE tests and histological analyses were performed at 2, 7, and 30 days post‐treatment to characterize SGN and glial cell degeneration. Part 2.
Chen H, Zhang Y, Wan H, Yang B, Liu T, Wang J, Liao H, Zhang Y, Zhang Z, Hua Q.   +9 more
europepmc   +2 more sources