Results 11 to 20 of about 13,484 (179)

Ouabain Relieves Sleep Deprivation–Induced Anxiety‐Like Behavior in Mice by Suppressing Hippocampal Neuroinflammation and Oxidative Stress

Brain and Behavior
Background: Sleep insufficiency has become a global public health challenge and is closely associated with the onset of mood and anxiety disorders.
Hanxiao Zhu, Wei Wang
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Radioimmunoassays, Ouabain-Like Material, and Ouabain [PDF]

Hypertension, 2005
To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved without ...
P.J. Hilton, W. McKinnon
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Ouabain and Serum Sodium [PDF]

Hypertension, 2005
To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by ≈3 mmol/L.1 Conversely, a progressive increase in salt intake ...
Gasowski, Jerzy, Manunta, Paolo, Bianchi, Giuseppe, Staessen, Jan A.   +3 more
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Wistar rats resistant to the hypertensive effects of ouabain exhibit enhanced cardiac vagal activity and elevated plasma levels of calcitonin gene-related peptide. [PDF]

PLoS ONE, 2014
Ouabain is a cardiac glycoside produced in the adrenal glands and hypothalamus. It affects the function of all cells by binding to Na+/K+-ATPase. Several lines of evidence suggest that endogenous ouabain could be involved in the pathogenesis of essential
Elham Ghadhanfar, Maie Al-Bader, Marian Turcani   +2 more
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Ouabain Increases Gap Junctional Communication in Epithelial Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce, Isabel Larre, Aida Castillo, Refugio García-Villegas, Adrián Romero, Catalina Flores-Maldonado, Jacqueline Martinez-Rendón, Rubén Gerardo Contreras, Marcelino Cereijido   +8 more
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Hypertensive effects of the iv administration of picomoles of ouabain

Brazilian Journal of Medical and Biological Research, 2011
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and
A.S. Padilha, M. Salaices, D.V. Vassallo, P.R. Batista, F.D.M. Siman   +4 more
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The Influence of Ouabain on Human Dendritic Cells Maturation

Mediators of Inflammation, 2014
Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation ...
C. R. Nascimento, R. C. Valente, J. Echevarria-Lima, C. F. L. Fontes, L. de Araujo-Martins, E. G. Araujo, V. M. Rumjanek   +6 more
doaj   +1 more source

On the structure of endogenous ouabain [PDF]

Proceedings of the National Academy of Sciences, 1999
The ouabain-like sodium pump inhibitor in mammals (so-called “endogenous ouabain”) has been considered a subtle structural isomer of ouabain. Its structural investigation, however, has long been hindered by the paucity of sample material.
A, Kawamura, J, Guo, Y, Itagaki, C, Bell, Y, Wang, G T, Haupert, S, Magil, R T, Gallagher, N, Berova, K, Nakanishi   +9 more
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NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation. [PDF]

Adv Sci (Weinh)
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Qiu C, Wang J, Li Z, Ji Q, Zhang H, Zhang Q, Zhang S, Yu J, Tao Y, Wu Y, Shi C, Zai Z, Zhang Z, Li Y, Bai Z, Hu S, Pan J, Yang Y, Wu S.   +18 more
europepmc   +2 more sources

Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400

Journal of Pharmacological Sciences, 2007
Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka, Hideaki Shimada, Iyuki Namekata, Toru Kawanishi, Naoko Iida-Tanaka, Koki Shigenobu   +5 more
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