Results 31 to 40 of about 29,553 (224)
Ouabain Increases Gap Junctional Communication in Epithelial Cells
Cellular Physiology and Biochemistry, 2014 Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce +8 more
doaj +1 more source
Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
doaj +1 more source
The Influence of Ouabain on Human Dendritic Cells Maturation
Mediators of Inflammation, 2014 Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation ...
C. R. Nascimento +6 more
doaj +1 more source
Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Biomedicines, 2022 Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain.
Paula Fernanda Kinoshita +7 more
doaj +1 more source
Intracellular free sodium and potassium, post-carbachol hyperpolarization, and extracellular potassium-undershoot in rat sympathetic neurones [PDF]
, 1983 Double-barrelled ion-sensitive microelectrodes were used to record the free intracellular Na+- and K+-concentrations ([Na+]i, [K+]i) and to determine their relation to changes in membrane potential and extracellular K+ ([K+]e) in rat sympathetic ganglia.
Brown +15 more
core +1 more source
Journal of Pharmacological Sciences, 2007 Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits ...
Hikaru Tanaka +5 more
doaj +1 more source
Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]
PLoS ONE, 2013 Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun +5 more
doaj +1 more source
Alpha- and beta-adrenergic mediation of changes in metabolism and Na/K exchange in rat brown fat [PDF]
, 1985 Double- and triple-barreled ion-sensitive microelectrodes were used to measure changes in extracellular K+ and Na+ concentrations ([K+]o, [Na+]o) in brown fat.
Coles, Jonathan A. +2 more
core +2 more sources
On the structure of endogenous ouabain [PDF]
Proceedings of the National Academy of Sciences, 1999 The ouabain-like sodium pump inhibitor in mammals (so-called “endogenous ouabain”) has been considered a subtle structural isomer of ouabain. Its structural investigation, however, has long been hindered by the paucity of sample material. Our recent purification of endogenous ouabain (3 μg) from bovine hypothalamus allowed the measurement of its1H-NMR.
A, Kawamura +9 more
openaire +2 more sources
Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice
Mediators of Inflammation, 2011 Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to
Danielle Ingrid Bezerra de Vasconcelos +7 more
doaj +1 more source