Results 31 to 40 of about 22,704 (219)

Neuroinflammation and Neutrophils: Modulation by Ouabain [PDF]

Frontiers in Pharmacology, 2022
Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration ...
Jacqueline Alves Leite, Luiz Henrique Agra Cavalcante-Silva, Martina Raissa Ribeiro, Geovanni de Morais Lima, Cristoforo Scavone, Sandra Rodrigues-Mascarenhas   +5 more
openaire   +3 more sources

Ouabain Effects on Human Anaplastic Thyroid Carcinoma 8505C Cells

, 2022
Anaplastic thyroid carcinoma (ATC) is a rare, but aggressive, carcinoma derived from follicular cells. While conventional treatments may improve patients’ survival, the lethality remains high.
Marcelle Novaes Andrade, de Paiva, Luciana Souza, Eliza Freitas Passos, da Silva, Joyle Moreira Carvalho, Denise Pires de Carvalho, Elizabeth Giestal-de-Araujo, Campos, Maria Luisa Arantes, Giestal-de-Araujo, Elizabeth, Maria Luisa Arantes Campos, Leandro Miranda-Alves, Teixeira, Mariana Pires, de Carvalho, Denise Pires, Natalia Ferreira Haddad, Luciana Souza de Paiva, Mariana Pires Teixeira, Camila Saggioro de Figueiredo, Miranda-Alves, Leandro, Haddad, Natalia Ferreira, Passos, Eliza Freitas, Andrade, Marcelle Novaes, Joyle Moreira Carvalho da Silva, de Figueiredo, Camila Saggioro   +21 more
core   +1 more source

An investigation using cultured human cell lines, of the involvement of vanadium, cation transport and phosphatidylinositol in the aetiology of bipolar manic-depressive psychosis [PDF]

, 2015
The symptoms, classification, occurrence and possible aetiologies of bipolar manic-depressive psychosis have been reviewed, with particular emphasis on the possible role of the vanadate ion (V5+) and cation transport in the illness.
Banks, Rosamonde Elizabeth, Naylor, Graham   +1 more
core   +1 more source

O‐GlcNAcylation Stimulation Modulates Na+/K+ ATPase and Improves Outcomes in Hemorrhagic Shock [PDF]

MedComm (2020)
Acute stimulation of O‐GlcNAcylation via NButGT injections in rats subjected to hemorrhagic shock improves hemodynamic parameters, reduces organ dysfunction, and restores ionic imbalance. These beneficial effects are notably mediated through modulation of the Na+/K+‐ATPase pump, highlighting O‐GlcNAcylation as a promising therapeutic target in ...
Dupas T, Vergnaud A, Aillerie V, Bouaud M, Erraud A, Pelé T, Persello A, de Oliveira B, Montnach J, Girardeau A, Lecomte J, Tessier N, Guyon M, Blangy‐Letheule A, Rivière M, Lebreton J, Tessier A, Bigot‐Corbel E, Leroux A, De Waard M, Prat N, Rozec B, Denis M, Lauzier B.   +23 more
europepmc   +2 more sources

Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

Frontiers in Physiology, 2020
The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer, Katja Bezjak, Urška Matkovič, Klemen Dolinar, Lake Q. Jiang, Katarina Miš, Katarina Gros, Kseniya Milovanova, Katja Perdan Pirkmajer, Katja Perdan Pirkmajer, Tomaž Marš, Leonid Kapilevich, Leonid Kapilevich, Alexander V. Chibalin   +13 more
doaj   +1 more source

Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]

PLoS ONE, 2017
Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou, Chen Xuan Pan, Jeremy Zuo, Frans A van der Hoorn   +3 more
doaj   +1 more source

The Metabolism of Ouabain in the Rat

Journal of Pharmacy and Pharmacology, 1959
Abstract The urinary and biliary excretion of ouabain by rats has been estimated by paper chromatographic, colorimetric and biological methods of assay. After a dose of 1 μg./g., ouabain was excreted to the extent of approximately 90 per cent in bile and 4 per cent in urine.
E, COX, G, ROXBURGH, S E, WRIGHT
openaire   +2 more sources

Ouabain only partially mimics the EtOH-induced facilitation of sIPSCs.

, 2013
Representative traces of the effects of (A1) 80 mM EtOH, (B1) 0.1 µM ouabain, and (C1) TTX+ouabain on sIPSC frequency and amplitude (average green traces = baseline; blue traces = baseline (+TTX); yellow = EtOH; red = ouabain).
Erik De Schutter (29220), Aya Wadleigh (286194), Marvin R. Diaz (286193), C. Fernando Valenzuela (219036), Shyam Kumar (286195)   +4 more
core   +1 more source

Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats

International Journal of Hypertension
Background. Ouabain, a Na+, K+-ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS).
Minna Tang, Jialu Hu, Wenshu Li, Ningzhi Zhang, Sisi Ning, Yan Yan, Zhaoqiang Cui   +6 more
doaj   +1 more source

Antiviral activity of ouabain against a Brazilian Zika virus strain

Scientific Reports, 2022
Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena   +9 more
doaj   +1 more source