Results 51 to 60 of about 29,553 (224)
Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]
, 1987 Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C. +4 more
core +1 more source
Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. [PDF]
PLoS ONE, 2017 Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of ...
Young Ou +3 more
doaj +1 more source
NaCl transport stimulates prostaglandin release in cultured renal epithelial (MDCK) cells [PDF]
, 1986 Prostaglandins (PGs) can modulate a variety of renal functions, including Na+ and Cl- reabsorption. However, it is not known if a direct interdependence exists between PG synthesis and transport activity. The present study was done to find out whether or
Bauer, C. +3 more
core +1 more source
Hypertension, 2016 In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases.
John M, Hamlyn, Mordecai P, Blaustein
openaire +2 more sources
Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]
, 2013 <p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R. +4 more
core +2 more sources
The Metabolism of Ouabain in the Rat
Journal of Pharmacy and Pharmacology, 1959 Abstract The urinary and biliary excretion of ouabain by rats has been estimated by paper chromatographic, colorimetric and biological methods of assay. After a dose of 1 μg./g., ouabain was excreted to the extent of approximately 90 per cent in bile and 4 per cent in urine.
E, COX, G, ROXBURGH, S E, WRIGHT
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Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats
International Journal of HypertensionBackground. Ouabain, a Na+, K+-ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS).
Minna Tang +6 more
doaj +1 more source
Antiviral activity of ouabain against a Brazilian Zika virus strain
Scientific Reports, 2022 Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho +9 more
doaj +1 more source
Advanced Science, EarlyView.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
wiley +1 more source
Ouabain suppresses the migratory behavior of lung cancer cells. [PDF]
PLoS ONE, 2013 The migratory capability of cancer cells is one of the most important hallmarks reflecting metastatic potential. Ouabain, an endogenous cardiac glycoside produced by the adrenal gland, has been previously reported to have anti-tumor activities; however ...
Varisa Pongrakhananon +2 more
doaj +1 more source