Results 51 to 60 of about 22,704 (219)
Ouabain in plasma from spontaneously hypertensive rats
, 1994 Ouabain has recently been identified in mammalian plasma with an apparent adrenocortical origin. The objectives of the present study were to determine whether boiled plasma supernatants (BPS) from spontaneously hypertensive rats (SHR) contained elevated
P. A. Doris
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Stabilisation of Na,K-ATPase structure by the cardiotonic steroid ouabain [PDF]
, 2013 Cardiotonic steroids such as ouabain bind with high affinity to the membrane-bound cation-transporting P-type Na,K-ATPase, leading to complete inhibition of the enzyme.
Wallace, Bonnie A. +4 more
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Ouabain Modulates Zymosan-Induced Peritonitis in Mice
Mediators of Inflammation, 2015 Ouabain, a potent inhibitor of the Na+, K+-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes.
Jacqueline Alves Leite +8 more
doaj +1 more source
Hypertension, 2016 In this brief article, we summarize recent reports about endogenous ouabain (EO), a cardiotonic steroid hormone. This includes analysis of mammalian EO, the discovery of EO isomers, regulation of intracellular signaling by EO, and the roles of EO in hypertension, pregnancy, and heart and kidney diseases.
John M, Hamlyn, Mordecai P, Blaustein
openaire +2 more sources
Endogenous ouabain regulates cell viability
, 2012 The endogenous cardiac steroid-like compounds, endogenous ouabain (EO) in particular, are present in the human circulation and are considered putative ligands of the inhibitory binding site of the plasma membrane Na+-K+-ATPase.
Hagit Cohen Ben-Ami +3 more
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Brazilian Journal of Medical and Biological Research, 2010 We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to
F.D.M. Siman +3 more
doaj
Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Ro 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Carlos Cruz‐Cortés +5 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Sneha Pallatt +3 more
wiley +1 more source
I hereby declare that the work presented in this document is based on research carried out by me, and that no part has previously been submitted for a degree in this or any other university [PDF]
, 1995 Inhibitors of known transport processes, in conjunction with ion substitution were used in biochemical, physiological and microelectrode studies to investigate the mechanisms underlying ion and fluid secretion across the Malpighian tubules of Locusta ...
Marshall, Sarah Louise
core
Modulation of TNF‐α mRNA stability by human antigen R and miR181s in sepsis‐induced immunoparalysis
EMBO Molecular Medicine, 2014 Immunoparalysis is an important pathological mechanism in sepsis. However, an effective small molecule therapy is lacking. Here, we show that ouabain, a Na+,K+‐ATPase ligand, can reverse immunoparalysis in vitro, in vivo, and in clinical samples. Notably,
Cao Dan +10 more
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