Results 71 to 80 of about 29,310 (202)

Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad

Cell Death and Disease, 2021
Activation of the apoptotic pathway is a major cause of progressive loss of function in chronic diseases such as neurodegenerative and diabetic kidney diseases.
Kristoffer Bernhem, Jacopo M. Fontana, Daniel Svensson, Liang Zhang, Linnéa M. Nilsson, Lena Scott, Hans Blom, Hjalmar Brismar, Anita Aperia   +8 more
doaj   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, Volume 293, Issue 8, Page 2248-2269, April 2026.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

Endogenous bioelectric currents promote differentiation of the mammalian lens [PDF]

, 2018
Acknowledgements We are grateful to Kevin S. Mackenzie in our imaging core facility. This work was supported by the University of Aberdeen (at which the majority of the experimental work was conducted).
Andley, Banno, Barrett, Bassnett, Bhat, Bhuyan, Blackiston, Bortner, Call, Cao, Chen, Chen, Chen, Eperon, Franco, Gwon, Gwon, Ibaraki, Kalous, Kolosova, Korlimbinis, Lampi, Lampi, Lee, Liu, Lois, Lovicu, Mathias, McCaig, Park, Patterson, Piatigorsky, Rajagopal, Robinson, Robinson, Sanderson, Sellitto, Shestopalov, Shestopalov, Sundelacruz, Sundelacruz, Sundelacruz, Thylefors, Ueda, Vaghefi, Wang, Wang, Wang, White, Wind, Wormstone, Yang, Zhao   +52 more
core   +1 more source

Auditory Neuropathy: Challenges and Significant Progress in Diagnosis and Treatment

Advanced Therapeutics, Volume 9, Issue 3, March 2026.
Auditory neuropathy is a complex disorder that causes sensorineural hearing impairment in patients. Recently, breakthrough progress has been made in the gene therapy of auditory neuropathy. This review focuses on auditory neuropathy, covering its pathophysiology, etiology, epidemiology, clinical manifestations, diagnostic techniques, treatment ...
Wen Xie, Ling Lu, Busheng Tong, Lian Fang, Qingqing Dai, Xiaowan Chen, Jieyu Qi, Xiaoyun Qian, Xia Gao, Renjie Chai, Jun Yang, Maoli Duan   +11 more
wiley   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Ouabain inhibits monocyte activation in vitro: prevention of the proinflammatory mCD14+/CD16+ subset appearance and cell-size progression

Journal of Experimental Pharmacology, 2012
Raphael C Valente,1 Elizabeth G Araujo,2 Vivian M Rumjanek11Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2Departamento de Neurobiologia, Universidade Federal Fluminense, Rio de ...
Valente RC, Araujo EG, Rumjanek VM
doaj  

Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons [PDF]

, 1984
Carbachol and γ-aminobutyric acid depolarize mammalian sympathetic neurons and increase the free extracellular K+-concentration. We have used double-barrelled ion-sensitive microelectrodes to determine changes of the membrane potential and of the free ...
Ballanyi, Klaus, Grafe, Peter, Reddy, M. M., Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel, Samantha M. Holland, Felice D. Kelly, Eric M. Baker, Jared Stoller, William Packwood, Xin Li, Ramon F. Barajas Jr., Charles S. Springer Jr., Martin M. Pike   +9 more
wiley   +1 more source

Nerol Attenuates Ouabain-Induced Arrhythmias [PDF]

Evidence-Based Complementary and Alternative Medicine, 2019
Nerol (C10H18O) is a monoterpene found in many essential oils, such as lemon balm and hop. In this study, we explored the contractile and electrophysiological properties of nerol and demonstrated its antiarrhythmic effects in guinea pig heart preparation.
José Evaldo Rodrigues de Menezes-Filho, Diego Santos de Souza, Artur Santos-Miranda, Valeska Moraes Cabral, José Nilson Andrade Santos, Jader dos Santos Cruz, Andreza Melo de Araujo, Carla Maria Lins de Vasconcelos   +7 more
openaire   +2 more sources

Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: The fact that ouabain has been identified as an endogenous substance, led us to inquire its physiological role in epithelial cells. Based on previous observations, we hypothesized that it influences processes related to cell contacts ...
Arturo Ponce, Isabel Larre, Aida Castillo, Catalina Flores-Maldonado, Odette Verdejo-Torres, Ruben Gerardo Contreras, Marcelino Cereijido   +6 more
doaj   +1 more source