Results 71 to 80 of about 22,704 (219)
The Journal of Physiology, Volume 604, Issue 18, Page 7799-7818, 15 September 2026.Abstract figure legend Contrary to the prevailing view, the therapeutic efficacy of sodium channel blockers in myotonia does not depend on inhibition of the transient sodium current (NaT) responsible for action potentials. In a mouse model of myotonia congenita, effective concentrations of sodium channel blockers did not reduce NaT, but consistently ...
Phil Walker +9 more
wiley +1 more source
Molecular mechanism of cofilin dephosphorylation by ouabain
, 2017 We previously reported that phosphorylated cofilin-triosephosphate isomerase (TPI) complex interacts with Na,K-ATPase and enhances the pump activity through the phosphorylation of cofilin via Rho-mediated signaling pathway.
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Journal of Experimental Pharmacology, 2012 Raphael C Valente,1 Elizabeth G Araujo,2 Vivian M Rumjanek11Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2Departamento de Neurobiologia, Universidade Federal Fluminense, Rio de ...
Valente RC, Araujo EG, Rumjanek VM
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Cancer Medicine, Volume 15, Issue 8, August 2026.Artificial intelligence accelerates cancer therapeutic development through an iterative, closed‐loop pipeline: from AI‐driven target and drug discovery, through automated synthesis and screening, to experimental validation in in vivo tumor models, culminating in clinical translation guided by patient data.
Tuğba Ören Varol, Mehmet Varol
wiley +1 more source
Induction by ouabain of hemoglobin synthesis in cultured friend erythroleukemic cells
, 1976 Induction of erythroid differentiation in ouabain-resistant murine erythroleukemia cells by ouabain is reported. Ouabain induction results in the appearance of hemoglobin-containing cells 12-24 hr earlier than induction of the same clone by dimethyl ...
Hunt, D. Margaret +3 more
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Ouabain Modulates the Distribution of Connexin 43 in Epithelial Cells
Cellular Physiology and Biochemistry, 2016 Background/Aims: The fact that ouabain has been identified as an endogenous substance, led us to inquire its physiological role in epithelial cells. Based on previous observations, we hypothesized that it influences processes related to cell contacts ...
Arturo Ponce +6 more
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Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza +9 more
wiley +1 more source
Frontiers in Physiology, 2020 Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na,K-ATPase, the enzyme, which pumps Na+ and K+ across plasma membrane of ...
Olga Dmitrievna Lopina +5 more
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Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2368-2387, August 2026.This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang +11 more
wiley +1 more source
, 2009 To determine the therapeutic potential of cardiac glycosides in androgen- independent prostate cancer, we examined ouabain-induced cytotoxic effect as well as the signaling pathways in PC-3 cells.
HUANG, YAO-TING;CHUEH, SHIH-CHIEH;TENG, CHE-MING;GUH, JIH-HWA +1 more
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