Results 81 to 90 of about 22,704 (219)
Excretion of ouabain by Malpighian tubules of Oncopeltus fasciatus
, 1984 An in vitro preparation of Malpighian tubules was used to investigate the excretion of the polar cardiac glycoside, ouabain, in Oncopeltus fasciatus.
J. Meredith, L. Moore, G. G. Scudder
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Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki +2 more
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Advanced Science, Volume 13, Issue 41, 22 July 2026.WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang +6 more
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Effect of ouabain on the plasma levels of CGRP and cGMP.
, 2014 The data are presented as the means (SDs); n = 10. Control, rats with implanted placebo pellets; Ouabain 63, rats treated for 40 days with 63 µg ouabain/kg/day, Ouabain 324, rats treated for 40 days with 63 µg ouabain/kg/day and then for 40 days with 324
Maie Al-Bader (639492) +2 more
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Na+,K+-ATPase is the membrane receptor of hormone ouabain
Communicative & Integrative Biology, 2010 At 10 nM, ouabain elicits changes in cell contacts, which are independent and usually in opposite direction to effects occurring at μM levels, suggesting that these depend on entirely different mechanisms.1 However, this does not discard the possibility ...
Isabel Larre, Marcelino Cereijido
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Novel Receptors for Ouabain: Studies in Adrenocortical Cells and Membranes
, 2002 Sodium-potassium pumps (Na pumps) are the only known plasma membrane receptors for cardiac glycosides. However, adrenocortical cells secrete an endogenous ouabain via an unknown mechanism that is subject to feedback inhibition via the cell ...
Bruce P. Hamilton +2 more
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Біологічні студії, 2014 It is known that calix[4]arene with cipher C-99 selectively and with high affinity capable of inhibiting the Na+, K+-ATPase (compared with a known inhibitor of this enzyme – ouabain) of smooth muscle cells plasma membrane preparations.
O. V. Tsymbalyuk
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Ouabain and vascular reactivity Brazilian
, 2020 Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension.
E Songu-Mize +3 more
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Antiapoptotic effect of ouabain on human umbilical vein endothelial cells
, 2004 The present study investigates the effect of ouabain on caspase-3 activation in human umbilical vein endothelial cells (HUVEC). Ouabain (EC(50) 20 nM) reduced caspase-3 activity in HUVEC treated for 24h in a medium deprived of fibroblast growth factor ...
TREVISI, LUCIA +4 more
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Journal of NeuroinflammationThere is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang +7 more
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