Results 101 to 110 of about 22,704 (219)

Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells

, 2006
It has been suggested that an endogenous inhibitor of the sodium pump, identified as ouabain, contributes to the regulation of blood pressure and the pathogenesis of certain forms of hypertension. Vascular endothelial cells, whose functional integrity is
TREVISI, LUCIA, LUCIANI, SISTO, PIGHIN, ISABELLA   +2 more
core   +1 more source

Reversal by EGTA of the enhanced secretory responsiveness of mast cells due to treatment with ouabain

, 1990
The effect of EGTA on the enhancement by ouabain of compound 4880-induced secretion from mast cells was compared with the effect on the Na+-K+ pump activity.
H. Bertelsen, T. Knudsen, T. Johansen, Johansen, T., Knudsen, T., Bertelsen, H.   +5 more
core   +2 more sources

Na-K-ATPase localization in teleost urinary bladder by [3H]ouabain autoradiography

, 1976
Previous studies on the urinary bladder of the seawater-acclimated winter flounder (pseudopleuronectes americanus) demonstrated that active Na and Cl transport were ouabain sensitive.
null Karnaky KJ, WB Kinter, JL Renfro, DS Miller   +3 more
core   +1 more source

Ouabain - the insulin of the heart.

International journal of clinical practice, 2010
Prior to the introduction of modern drugs like angiotensin converting enzyme inhibitors and β-adrenergic receptor antagonists, the cardiac glycoside ouabain (referred to as g-Strophanthin in German) has routinely been used in treatment of heart diseases.
openaire   +2 more sources

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology
Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways.
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
doaj   +1 more source

Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling.

PLoS ONE, 2019
It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio.
Larisa V Smolyaninova, Alexandra A Shiyan, Leonid V Kapilevich, Alexander V Lopachev, Tatiana N Fedorova, Tatiana S Klementieva, Aleksey A Moskovtsev, Aslan A Kubatiev, Sergei N Orlov   +8 more
doaj   +1 more source

Effects of ouabain and amiloride on Na pathways in turtle bladders

, 1975
In a Na-rich bathing system, addition of amiloride to the mucosal fluid of turtle bladders produces decreased in the transepithelial potential difference (PD), short-circuiting current (I-sc), and conductance.
WA Brodsky, T Wilczewski
core   +1 more source

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule.
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu   +12 more
doaj   +1 more source

Protective effects of dextromethorphan and tizanidine on ouabain-induced arrhythmias

, 2002
The effects of the opioid agonist dextromethorphan and the alpha(2)-adrenoceptor agonist tizanidine on ouabain-induced cardiac arrhythmias were investigated in rats.
Sevgi, S., Oezek, M., Ozek, Mehmet, Sevgi, S, Ueresin, Y., Uresin, Y   +5 more
core   +1 more source

Ouabain is secreted by the adrenal gland in awake dogs

, 1993
Ouabain has been identified in the plasma and adrenal glands of several mammals, including humans. To investigate possible adrenal secretion of ouabain in vivo, at rest, and in response to acute blood volume changes, we prepared trained adult dogs (n ...
D. Shurtleff, D. S. Gann, J. M. Hamlyn, M. P. Lilly, B. R. Boulanger, J. Laredo   +5 more
core   +1 more source