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Monosodium glutamate-mediated Ca<sup>2+</sup>-dependent intestinal epithelial ion transports in health and IBS-D in male mice. [PDF]
Physiol RepWang Y, Chu F, Gong Y, Guo R, Dong H.
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Overexpression of ATP1B2 promotes cancer cell migration and inhibits apoptosis in patients with esophageal squamous cell carcinoma. [PDF]
Oncol RepLiu FF +6 more
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Endogenous Ouabain Is Not Ouabain
Hypertension, 2014The concept of a circulating digitalis-like inhibitor of the sodium pump, Na+, K+-ATPase, evolved from studies performed in the 1960s. De Wardener et al1 addressed the question of whether a small increase in the glomerular filtration rate together with changes in the concentration of the more recently discovered hormone aldosterone could explain the ...
Lynley K, Lewis +5 more
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Is the Circulating Ouabain-like Compound Ouabain?
American Journal of Hypertension, 1994The evidence is very strong for a circulating inhibitor of the sodium, potassium ATPase in volume-expanded hypertension. Recently, this inhibitor was isolated from human plasma and identified as ouabain. We are reporting our results using a very specific and sensitive immunoassay for ouabain with which we were unable to detect or able to detect only ...
E P, Gomez-Sanchez +4 more
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Cell Calcium, 2020
In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca2+ concentration ([Ca2+]CYT) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly,
Mordecai P. Blaustein, John M. Hamlyn
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In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca2+ concentration ([Ca2+]CYT) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly,
Mordecai P. Blaustein, John M. Hamlyn
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Studies on the cardiotoxicity of ouabain
Canadian Journal of Physiology and Pharmacology, 1969Pretreatment with reserpine in a catecholamine-depleting dosage schedule greatly increased the arrhythmic and lethal dose of ouabain in cats. Pretreatment with reserpine immediately before the administration of ouabain also increased these doses significantly but the effect was less marked than that produced by 24-h pretreatment.
A K, Reynolds, M L, Horne
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Ouabain as a Mammalian Hormone
Annals of the New York Academy of Sciences, 2003Abstract: Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the μ chain of IgM ...
Wilhelm, Schoner +12 more
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Current Opinion in Nephrology and Hypertension, 1998
Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced ...
A, Goto, K, Yamada
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Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced ...
A, Goto, K, Yamada
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Mechanisms of ouabain toxicity
The FASEB Journal, 2003ABSTRACT The suggested involvement of ouabain in hypertension raised the need for a better understanding of its cellular action, but the mechanisms of ouabain toxicity are only now being uncovered. In the present study, we show that reduced glutathione (GSH) protected ouabain‐sensitive (OS) cells from ouabain ...
Raphael C, Valente +5 more
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