Results 111 to 120 of about 19,639 (216)

Effects of ouabain on endothelium-dependent response

, 2017
Ouabain is an inhibitor of sodium-potassium adenosine triphosphatase (Na+/ K+-ATPase, also known as Na+ pumps). It is released by high sodium chloride concentration from hypothalamus and adrenals.
He, CR, Leung, SWS, Vanhoutte, PMGR
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Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling.

PLoS ONE, 2019
It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio.
Larisa V Smolyaninova, Alexandra A Shiyan, Leonid V Kapilevich, Alexander V Lopachev, Tatiana N Fedorova, Tatiana S Klementieva, Aleksey A Moskovtsev, Aslan A Kubatiev, Sergei N Orlov   +8 more
doaj   +1 more source

Resolution of the insect ouabain paradox

, 2004
Many insects are highly resistant to plant toxins, such as the cardiac glycoside ouabain. How can the epithelia that must handle such toxins, also be refractory to them? In Drosophila, the Malpighian (renal) tubule contains large amounts of Na+,K+ ATPase
Torrie, LS, Southall, TD, Dinsmore, AJ, Radford, JC, Kean, L, Davies, SA, Dow, JAT   +6 more
core   +1 more source

Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule.
Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad A. Chaudhry, Kyle Maxwell, Steven T. Haller, Christopher A. Drummond, David J. Kennedy, Jiang Tian, Deepak Malhotra, Zi‐jian Xie, Joseph I. Shapiro, Jiang Liu   +12 more
doaj   +1 more source

The Effect of Paroxetine on Ouabain-Induced Toxicity in Isolated Guinea Pig Atria [PDF]

Acta Medica Iranica, 2011
It has been reported that selective serotonin reuptake inhibitors (SSRIs) possess some cardiac effects. In the present study we have investigated the effect of paroxetine (PX), a potent SSRI agent, on spontaneously as well as ouabain-induced arrhythmia ...
Farzaneh Najar, Peyvand Bina, Sima Sabzeh-Khah, Azam Bakhtiarian, Mir-Jamal Hosseini, Abbas Pousti   +5 more
doaj  

Cardiac glycoside binding sites in cultured heart muscle cells [PDF]

, 1984
Erdmann, E., B. Zwißler, W. Krawietz, E. Erdmann, B. Wagenknecht, Wagenknecht, B., Werdan, K., Zwißler, Bernhard, K. Werdan, Krawietz, W.   +9 more
core   +1 more source

Vascular endothelium as a target for endogenous ouabain: studies on the effect of ouabain on human endothelial cells

, 2006
It has been suggested that an endogenous inhibitor of the sodium pump, identified as ouabain, contributes to the regulation of blood pressure and the pathogenesis of certain forms of hypertension. Vascular endothelial cells, whose functional integrity is
TREVISI, LUCIA, LUCIANI, SISTO, PIGHIN, ISABELLA   +2 more
core   +1 more source

Biological implication of conformational flexibility in ouabain: observations with two ouabain phosphate isomers. Biochemistry 40:5835–5844

, 2001
: Ouabain is a highly polar and unusually potent sodium pump inhibitor that possesses uncommon conformational flexibility in its steroid A-ring moiety.
Akira Kawamura, Leif M Abrell, Federica Maggiali, Jason Labutti, John M Hamlyn, Koji Nakanishi, Sheila Magil, | Garner, Nina Berova, T Haupert Jr   +9 more
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Trophic effect of Ouabain in central neurons

, 2021
Ouabain is a digitalic steroid hormone that inhibits Na+, K+ - ATPase activity. However, during the last years, it has been proposed that Na+, K+ - ATPase acts as a membrane receptor being endogenous ouabain its physiological ligand. Data from literature
Corrêa, Gustavo de Rezende
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The Effects of Cations on Ouabain Binding by Human Erythrocytes

, 1973
51 p.Ouabain binding by the human erythrosyte membrane is reversible, exhibits a high of chemical specificity, and can be detected at ouabain concentrations as low as lxlO-l0M.
Rodgers, John C.
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