Results 91 to 100 of about 22,704 (219)

Ouabain modulates ciliogenesis in epithelial cells

, 2011
The exchange of substances between higher organisms and the environment occurs across transporting epithelia whose basic features are tight junctions (TJs) that seal the intercellular space, and polarity, which enables cells to transport ...
Catalina Flores-Maldonado, Ruben G. Contreras, Aida Castillo, Marcelino Cereijido, Isabel Larre, Jesus Muñoz-Estrada, Ivan Galvan   +6 more
core   +1 more source

Ouabain inhibition of Na/K-ATPase across the retina prevents signed refractive compensation to lens-induced defocus, but not default ocular growth in young chicks [v1; ref status: indexed, http://f1000r.es/rt]

F1000Research, 2013
Purpose: The relevance of retinal integrity and energy pathways to ocular growth and induction of refractive errors has seldom been investigated. Thus, we used ouabain to target the channels that are essential for the maintenance of membrane potentials ...
Melanie J Murphy, Sheila Gillard Crewther   +1 more
doaj   +1 more source

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization

Frontiers in Immunology
IntroductionMycobacterium abscessus (M. abscessus) is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its ...
Nan Li, Nan Li, Nan Li, Songqiang Huang, Songqiang Huang, Xing Shi, Kuo Lu, Kuo Lu, Xiu Yu, Chen Qiu, Rongchang Chen   +10 more
doaj   +1 more source

Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria

Advances in Pharmacological Sciences, 2016
Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-
Somayeh Moradi, Vahid Nikoui, Muhammad Imran Khan, Shayan Amiri, Farahnaz Jazaeri, Azam Bakhtiarian   +5 more
doaj   +1 more source

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities

Journal of Pharmacological Sciences, 2018
Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting ...
Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Resolution of the insect ouabain paradox

, 2004
Many insects are highly resistant to plant toxins, such as the cardiac glycoside ouabain. How can the epithelia that must handle such toxins, also be refractory to them? In Drosophila, the Malpighian (renal) tubule contains large amounts of Na+,K+ ATPase
Torrie, LS, Southall, TD, Dinsmore, AJ, Radford, JC, Kean, L, Davies, SA, Dow, JAT   +6 more
core   +1 more source

Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways

Brain Sciences
Background: Ouabain is a steroid hormone that binds to the sodium pump (Na+, K+-ATPase) at physiological (nanomolar) concentrations, activating different signaling pathways.
Amanda Candida da Rocha Oliveira, Camila Saggioro Figueiredo, Ícaro Raony, Juliana Salles Von-Held-Ventura, Marcelo Gomes Granja, Thalita Mázala-de-Oliveira, Vinícius Henrique Pedrosa-Soares, Aline Araujo dos Santos, Elizabeth Giestal-de-Araujo   +8 more
doaj   +1 more source

Enhancement (by ATP, insulin, and lack of divalent cations) of ouabain inhibition of cation transport and ouabain binding in frog skeletal muscle; effect of insulin and ouabain on sarcolemmal (Na + K)MgATPase

, 1977
Using small, intact frog muscles, the basic properties of Na+ and K+ transport were shown to resemble those of the (Na+ + K+) Mg2+ATPase (EC 3.6.1.3) isolated from skeletal muscle, (a) External K+ is essential for Na+ exit and K+ entry after the muscles
J. S. Still, G. Madapallimattam, J. F. Manery, E. E. Dryden   +3 more
core   +1 more source

Vascular reactivity of isolated rat mesenteric arterioles in the presence and absence of ouabain [PDF]

, 2006
The microvasculature plays a significant role in the regulation of blood pressure and regional blood supply. Cardiotonic steroids like the adrenal cortical hormone (ouabain) have been proposed to play a role in some forms of hypertension.
Chawla, Rohit
core   +1 more source

Voltage dependence of the Na-K ATPase: measurements of ouabain-dependent membrane current and ouabain binding in oocytes of Xenopus laevis

, 1988
Ouabain- or dihydroouabain(DHO)-sensitive membrane currents and binding of 3H-ouabain were investigated under voltage-clamp conditions in full-grown prophase-arrested oocytes of Xenopus laevis.
Schwarz, W., Schweigert, B., Lafaire, A.
core   +1 more source