Results 91 to 100 of about 19,639 (216)

Na+,K+-ATPase is the membrane receptor of hormone ouabain

Communicative & Integrative Biology, 2010
At 10 nM, ouabain elicits changes in cell contacts, which are independent and usually in opposite direction to effects occurring at μM levels, suggesting that these depend on entirely different mechanisms.1 However, this does not discard the possibility ...
Isabel Larre, Marcelino Cereijido
doaj   +1 more source

Comparative analysis of the mechanokinetics of contractile activity of myometrium smooth muscles under calixarene C-99 and ouabain action

Біологічні студії, 2014
It is known that calix[4]arene with cipher C-99 selectively and with high affinity capable of inhibiting the Na+, K+-ATPase (compared with a known inhibitor of this enzyme – ouabain) of smooth muscle cells plasma membrane preparations.
O. V. Tsymbalyuk
doaj   +1 more source

An investigation using cultured human cell lines, of the involvement of vanadium, cation transport and phosphatidylinositol in the aetiology of bipolar manic-depressive psychosis

, 2015
The symptoms, classification, occurrence and possible aetiologies of bipolar manic-depressive psychosis have been reviewed, with particular emphasis on the possible role of the vanadate ion (V5+) and cation transport in the illness.
Banks, Rosamonde Elizabeth, Naylor, Graham   +1 more
core  

Physiological role of hormone ouabain [PDF]

, 2021
Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its ...
Cereijido, M., Ponce, A., Castillo, A., Larre, M. I., Hinojosa, L.   +4 more
core  

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD

Journal of Neuroinflammation
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang   +7 more
doaj   +1 more source

Ouabain inhibition of Na/K-ATPase across the retina prevents signed refractive compensation to lens-induced defocus, but not default ocular growth in young chicks [v1; ref status: indexed, http://f1000r.es/rt]

F1000Research, 2013
Purpose: The relevance of retinal integrity and energy pathways to ocular growth and induction of refractive errors has seldom been investigated. Thus, we used ouabain to target the channels that are essential for the maintenance of membrane potentials ...
Melanie J Murphy, Sheila Gillard Crewther   +1 more
doaj   +1 more source

Deleterious effect of ouabain on myocardial function during hypoxia

, 1989
The effect of cardiac glycosides on myocardial function during hypoxia is controversial. Accordingly, we studied left ventricular performance during hypoxia and reoxygenation in the presence of a mildly inotropic, nontoxic dose of ouabain using isolated,
M. J. Cunningham, C. S. Apstein, E. O. Weinberg, B. H. Lorell   +3 more
core   +1 more source

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities

Journal of Pharmacological Sciences, 2018
Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting ...
Yuki Kurauchi, Kazuki Noma, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki   +4 more
doaj   +1 more source

Chronic ouabain infusion does not cause hypertension in sheep

, 1996
Ouabain is claimed to be a hormone of adrenal origin, capable of raising arterial pressure in rats. We infused ouabain in conscious sheep under carefully controlled circumstances to determine its effects on blood pressure, urine electrolytes, and ...
C. J. Charles, M. T. Rademaker, M. G. Nicholls, G. B. Pidgeon, A. M. Richards, R. R. Bailey, T. G. Yandle, K. L. Lynn, L. K. Lewis   +8 more
core   +1 more source

Antagonism of the inotropic action of ouabain by aldosterone

, 1965
Aldosterone (3.3 x 10–8 to 10–7 m) exerted a small positive inotropic effect on cat Langendorff heart preparations depressed by pentobarbital and on cat papillary muscles depressed by low calcium.
Allan M. Lefer, George Sayers
core   +1 more source