Results 61 to 70 of about 22,704 (219)

Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes

Glia, Volume 74, Issue 9, September 2026.
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani, Kabeer Abubakar, Tin Luka Petanjek, Monique Esclapez, Anton Ivanov, Christophe Bernard   +5 more
wiley   +1 more source

Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia

Biomolecules, 2020
Pathological homocysteine (HCY) accumulation in the human plasma, known as hyperhomocysteinemia, exacerbates neurodegenerative diseases because, in the brain, this amino acid acts as a persistent N-methyl-d-aspartate receptor agonist.
Maria A. Ivanova, Arina D. Kokorina, Polina D. Timofeeva, Tatiana V. Karelina, Polina A. Abushik, Julia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov   +7 more
doaj   +1 more source

Antagonism of the inotropic action of ouabain by aldosterone

, 1965
Aldosterone (3.3 x 10–8 to 10–7 m) exerted a small positive inotropic effect on cat Langendorff heart preparations depressed by pentobarbital and on cat papillary muscles depressed by low calcium.
Allan M. Lefer, George Sayers
core   +1 more source

Effects of Ouabain, Atropine, and Ouabain and Atropine, on A-V Nodal Conduction in Man [PDF]

Circulation Research, 1967
The prolongation of A-V transmission time that occurs with increasing rates of right atrial pacing has been used to study the effect of ouabain and of ouabain plus atropine on A-V nodal conduction in 14 patients with normal A-V nodes. Drugs were injected into the superior vena cava or pulmonary artery over a 1- to 2-min period.
R A, Carleton, P H, Miller, J S, Graettinger   +2 more
openaire   +2 more sources

Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The in‐silico data showed that fisetin binds stably with the autophagy receptors and synaptic density regulators. Further, in‐vitro data confirmed the restoration of Aβ1‐42 disrupted autophagy by fisetin. Fisetin restored the oxidative stress and ion channels, along with a reduction of AChE activity.
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh   +2 more
wiley   +1 more source

Mechanisms of ouabain-induced arterial muscle contraction

, 1980
Ouabain caused dose-related contractions in helically cut strips of cerebral, mesenteric, renal, and femoral arteries isolated from dogs and monkeys; the contractions were elicited at lower concentrations in cerebral than in the peripheral arteries ...
N. Toda
core   +1 more source

Carvacrol Mitigates TNF‐α‐Driven Oxidative and Bioenergetic Impairment in L6 Rat Myoblasts

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Carvacrol (6.25 µg/mL) attenuates TNF‐α‐induced bioenergetic toxicity in L6 rat myoblasts by reducing LDH release by 79%, quenching intracellular ROS, partially restoring mitochondrial membrane potential and ion‐dependent ATPase activities, recovering catalase and SOD function, and upregulating SIRT1 and AMPK mRNA—identifying carvacrol as a multi ...
Ali M. Albarrati, Rakan I. Nazer
wiley   +1 more source

Ouabain partially mimics the EtOH-induced, action potential-dependent potentiation of CGN-I_tonic.

, 2013
Exemplar traces of the effect of (A1) 80 mM EtOH, (B1), 0.1 µM ouabain, and (C1) 0.1 µM ouabain in the presence of TTX on the CGN-Itonic. Summary of the effect of (A2) EtOH, (B2) ouabain, and (C2) TTX+ouabain on the amplitude of CGN-Itonic ...
Erik De Schutter (29220), Aya Wadleigh (286194), Marvin R. Diaz (286193), C. Fernando Valenzuela (219036), Shyam Kumar (286195)   +4 more
core   +1 more source

Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad

Cell Death and Disease, 2021
Activation of the apoptotic pathway is a major cause of progressive loss of function in chronic diseases such as neurodegenerative and diabetic kidney diseases.
Kristoffer Bernhem, Jacopo M. Fontana, Daniel Svensson, Liang Zhang, Linnéa M. Nilsson, Lena Scott, Hans Blom, Hjalmar Brismar, Anita Aperia   +8 more
doaj   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source