Results 1 to 10 of about 6,765 (157)

“Oxygen sensing” by Na,K-ATPase: these miraculous thiols [PDF]

Frontiers in Physiology, 2016
Control over the Na,K-ATPase function plays a central role in adaptation of the organisms to hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its oxygen-sensitivity is mediated by a variety of redox-sensitive ...
Anna Bogdanova, Irina Yu Petrushanko, Pablo Hernansanz-Agustín, Pablo Hernansanz-Agustín, Antonio Martínez-Ruiz   +4 more
doaj   +3 more sources

Impact of hyperbilirubinemia on rat cardiomyocyte injury [PDF]

BMC Cardiovascular Disorders
Background To investigate bilirubin-induced injury in rat myocardial cells at varying concentrations. Methods The study utilized the rat cardiomyocyte cell line H9C2 and primary rat cardiomyocytes. Bilirubin-rich and control sera were prepared, and cells
Jiajia Zhao, Hui Ye, Xiangjun Wu, Danying Wang, Yuanxiang Ke, Weijie Fang   +5 more
doaj   +2 more sources

Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis

Frontiers in Aging Neuroscience, 2022
Vascular dementia (VaD) is the second most common cause of cognitive impairment amongst the elderly. However, there are no known disease-modifying therapies for VaD, probably due to incomplete understanding of the molecular basis of the disease.
Sasha A. Philbert, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper, Garth J. S. Cooper   +7 more
doaj   +1 more source

The Effects of Altered Membrane Cholesterol Levels on Sodium Pump Activity in Subclinical Hypothyroidism [PDF]

Endocrinology and Metabolism, 2017
BackgroundMetabolic dysfunctions characteristic of overt hypothyroidism (OH) start at the early stage of subclinical hypothyroidism (SCH). Na+/K+-ATPase (the sodium pump) is a transmembrane enzyme that plays a vital role in cellular activities in ...
Suparna Roy, Anindya Dasgupta
doaj   +1 more source

Oxidant/antioxidant status in Type-2 diabetes mellitus patients with metabolic syndrome

Journal of Research in Medical Sciences, 2021
Background: The concurrence of metabolic syndrome (MS) and diabetes mellitus (DM) is increasing worldwide. The long-term complications of these chronic diseases are a threat to patients' well-being.
Ali Najafi, Morteza Pourfarzam, Fouzieh Zadhoush   +2 more
doaj   +1 more source

ATP1A3-Related Disorders: An Ever-Expanding Clinical Spectrum

Frontiers in Neurology, 2021
The Na+/K+ ATPases are Sodium-Potassium exchanging pumps, with a heteromeric α-β-γ protein complex. The α3 isoform is required as a rescue pump, after repeated action potentials, with a distribution predominantly in neurons of the central nervous system.
Philippe A. Salles, Philippe A. Salles, Ignacio F. Mata, Tobias Brünger, Dennis Lal, Hubert H. Fernandez   +5 more
doaj   +1 more source

Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na+/K+-ATPase Dysfunction in Vascular Dementia

Frontiers in Aging Neuroscience, 2022
Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the ...
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J. Church, Richard D. Unwin, Richard D. Unwin, Garth J. S. Cooper, Garth J. S. Cooper   +7 more
doaj   +1 more source

Effects of Sodium-Potassium-Exchanging ATPase and Nitric Oxide on Ethanol Induced Relaxations

Turkiye Klinikleri Journal of Medical Sciences, 2017
Objective: Alcohol is widely used in the world and can cause gastrointestinal (GI) disturbances. Elucidating the molecular mechanism of alcohol in the GI tract may contribute to the therapeutic approaches on GI diseases caused by alcohol. So in the present study we aimed to elucidate the molecular mechanism of ethanol on isolated mouse gastric fundus ...
Derya KAYA, Naciye YAKTUBAY DÖNDAŞ
openaire   +2 more sources

Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens [PDF]

, 2010
Lenses of adult Atlantic salmon fed with a plant oil and plant protein-based diet (plant diet) were compared to lenses of fish fed a diet based on traditional marine ingredients (marine diet) with respect to biochemical composition and functionality ex ...
Baslow, Bell, Bell, Bell, Bjerkås, Bjerkås, Bjerkås, Bjerkås, Breck, Breck, Breck, Breck, Brodtkorb, Chan, Christiane Tröβe, Delamere, Duston, Hargis, Hawse, Iwata, Jeremy D. Rhodes, Jobling, Jordal, Julie Sanderson, Kantorow, Lu, Menzies, Mizuno, Ng, Nilsen, Olav Breck, Rune Waagbø, Sneddon, Sutherland, Tacon, Toivonen, Torstensen, Torstensen, Torstensen, Tröβe, Tröβe, Turchini, Untergasser, Ursini, Vandesompele, Vemuri, Virtanen, Waagbø, Waagbø, Waagbø, Wall, Yeagle, Zhang   +52 more
core   +1 more source

Management of hyperkalemia in the acutely ill patient. [PDF]

, 2019
PURPOSE:To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients. METHODS:We searched MEDLINE and EMBASE for relevant papers published in English between Jan 1, 1938, and July 1,
Dépret, François, Legrand, Matthieu, Liu, Kathleen D, Peacock, W Frank, Rafique, Zubaid, Rossignol, Patrick   +5 more
core   +3 more sources