Results 41 to 50 of about 6,765 (157)

3D time-varying simulations of Ca2+ dynamics in arterial coupled cells: A massively parallel implementation [PDF]

, 2017
Preferential locations of atherosclerotic plaque are strongly associated with the areas of low wall shear stress and disturbed haemodynamic characteristics such as flow detachment, flow recirculation and oscillatory flow.
Ayachit, Bedner, Behringer, Bennett, Bloor, Bloor, Boileau, Boileau, Brankin, Brisset, Bukauskas, Burnier, Caro, Chen, Cilla, Comerford, David, Davignon, Emerson, Gropp, Himburg, Kapela, Koenigsberger, Koenigsberger, Ku, Lemon, Li, Malek, Murray, Olesen, Plank, Rackauskas, Rohrig, Schroeder, Seppey, Shaikh, Tran, Van Rijen, Weller, Wilkins, Yamamoto, Yamamoto   +41 more
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Potassium silicate improves cellular sodium homeostasis in wheat (Triticum aestivum L.) cultivars differing in salt resistance

Plant Biology, EarlyView.
Potassium silicate can decrease the uptake of sodium (Na+) into wheat cells by affecting the Na+ uptake channels and increasing ion homeostasis. Abstract Salinity causes negative impacts on crops. We investigated the effect of potassium silicate (K2SiO3) on the cytosolic uptake of sodium, [Na+]cyt, in mesophyll protoplasts of wheat cultivars differing ...
M. T. Javed, S. H. Morgan, S. Lindberg
wiley   +1 more source

The two-pore channel TPCN2 mediates NAADP-dependent Ca-release from lysosomal stores [PDF]

, 2009
Second messenger-induced Ca2+-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP3), Ca2+, and cyclic ADP ribose (cADPR) that trigger Ca2+-release from the ...
Xiangang Zong, Michael Schieder, Hartmut Cuny, Stefanie Fenske, Christian Gruner, Katrin Rötzer, Oliver Griesbeck, Hartmann Harz, Martin Biel, Christian Wahl-Schott, A Beck, G Berridge, MJ Berridge, FX Boittin, EJ Bowman, LM Broad, PJ Calcraft, JM Cancela, D Churamani, GC Churchill, DE Clapham, DE Clapham, A Galione, A Galione, JV Gerasimenko, G Grynkiewicz, AH Guse, K Ishibashi, HC Lee, HC Lee, F Malavasi, R Masgrau, K Mikoshiba, AJ Morgan, B Much, E Peiter, BC Schroeder, M Steen, H Streb, C Wahl-Schott, FH Yu, R Zalk, N Zerangue   +42 more
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Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Bioenergetic mechanisms of seizure control [PDF]

, 2018
Epilepsy is characterized by the regular occurrence of seizures, which follow a stereotypical sequence of alterations in the electroencephalogram. Seizures are typically a self limiting phenomenon, concluding finally in the cessation of hypersynchronous ...
Alon Friedman, Alon Friedman, Jakub Otáhal, Nikolaus Berndt, Nikolaus Berndt, Ofer Prager, Richard Kovács, Siegrun Gabriel, Zoltan Gerevich   +8 more
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Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

Comparative Proteomic Analysis of Hymenolepis diminuta Cysticercoid and Adult Stages [PDF]

, 2018
Cestodiases are common parasitic diseases of animals and humans. As cestodes have complex lifecycles, hexacanth larvae, metacestodes (including cysticercoids), and adults produce proteins allowing them to establish invasion and to survive in the hostile ...
Bien, Justyna, Conn, David Bruce, Mlocicki, Daniel, Nareaho, Anu, Salamatin, Ruslan, Savijoki, Kirsi, Sulima, Anna   +6 more
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Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation [PDF]

, 2009
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (leaves 67-71).Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in ...
Shin, Yongdae
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