Results 61 to 70 of about 189,720 (274)

Crystal Structure of Prp5p Reveals Interdomain Interactions that Impact Spliceosome Assembly

Cell Reports, 2013
The DEAD-box adenosine triphosphatase (ATPase) Prp5p facilitates U2 small nuclear ribonucleoprotein particle (snRNP) binding to the intron branch site region during spliceosome assembly. We present crystal structures of S.
Zhi-Min Zhang, Fei Yang, Jinru Zhang, Qing Tang, Jie Li, Jing Gu, Jiahai Zhou, Yong-Zhen Xu   +7 more
doaj   +1 more source

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Human RNA capping is critical for mRNA splicing, protection of RNA from 5′ exonucleases in the cytoplasm, and targeting to the ribosome. Human RNMT, CMTR1, and CMTR2 are RNA methyltransferases involved in the RNA capping process. They play a significant role in the proliferation and differentiation of embryonic stem cells and have been ...
Fatemeh Taherian, Mark F. Mabanglo, Taraneh Hajian, Sarah Tucker, Emilija Kalinic, Sumera Perveen, Ahmed Aman, Masoud Vedadi   +7 more
wiley   +1 more source

Adiponectin Protects Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Suppressing Autophagy

Journal of Immunology Research, 2022
Adiponectin is a cytokine produced by adipocytes and acts as a potential cardioprotective agent and plays an important role in myocardial ischemia/reperfusion injury. In a myocardial hypoxia/reoxygenation model using neonatal rat ventricular myocytes, we
Jia Guo, Kaiyi Zhu, Zhidong Li, Chuanshi Xiao   +3 more
doaj   +1 more source

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
Chirality‐directed strategy designed by copper‐based nanoregulator (Cu‐D‐Car@HA) to potentiate collaborative cuproptosis‐immunotherapy by overcoming tumor resistance to cuproptosis highlights a materials‐based method for superior cuproptosis‐immunotherapy.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
wiley   +1 more source

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Scientific Reports, 2017
2-Oxoadenosine (2-oxo-Ado), an oxidized form of adenosine, is cytotoxic and induces growth arrest and cell death, which has potential as an anti-cancer drug. However, it is not well understood how 2-oxo-Ado exerts its cytotoxicity.
Shinji Asada, Eiko Ohta, Yoriko Akimoto, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu   +5 more
doaj   +1 more source

Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast

Biotechnology and Bioengineering, Volume 122, Issue 12, Page 3486-3495, December 2025.
Plouviez et al. give a perspective on the terminology used for describing the mechanisms of polyphosphate accumulation in microalgae and yeast. Their differentiation of mechanisms is based on environmental P availability, polyP chemistry, genetics, or cellular function as described in recent literature.
Maxence Plouviez, Philipp Demling, Alexander Deitert, Jana Fees, Makarius Baier, Tobias Karmainski, Lars M. Blank, Benoit Guieysse   +7 more
wiley   +1 more source

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Md. Sakhawat Hossain, Sanzida Khatun, Md Mojnu Mia, Fatematuz Zohora, Md. Rifat Sarker, K. M. Tanjida Islam, Md. Abu Sayeed, Moushumi Afroza Mou, Sherif Hamidu, Fatima Hamidu, A. M. Wasaf Hasan, Sanjida Mumtaj, Md Khaled Hossain, Md Sohel   +13 more
wiley   +1 more source

Prognostic Implications of SMARCA4, ARID1A, and Other BAF Mutations in Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 14, Issue 24, December 2025.
ABSTRACT Background and Methods Non‐small cell lung cancer (NSCLC) outcomes have improved remarkably with the widespread use of immune checkpoint inhibitors and small molecule inhibitors targeting driver mutations. Nevertheless, many patients continue to experience suboptimal outcomes. The prevalence of mutations in the BAF (BRG1/BRM‐associated factor)
Alexis Khalil, Michael P. Collins, Alfonso Quintás‐Cardama   +2 more
wiley   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source