Results 271 to 280 of about 253,092 (356)

Selective [9‐15N] Guanosine for NMR Studies of Large RNAs

open access: yesChemBioChem, Accepted Article.
RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that control RNA structure and dynamics is critical for understanding their mechanisms of action. To mitigate factors that have limited studies of large, functionally relevant RNAs by solution NMR spectroscopy, we have extended a recently described 2H ...
Solomon K. Attionu   +5 more
wiley   +1 more source

Prodrug-inspired adenosine triphosphate-activatable celastrol-Fe(III) chelate for cancer therapy. [PDF]

open access: yesSci Adv
Li H   +15 more
europepmc   +1 more source

Synthesis of 2‐Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA

open access: yesChemBioChem, EarlyView.
A series of 2‐substituted adenosine 5′‐O‐triphosphate derivatives is synthesized and tested as substrates for polymerases. In vitro transcription with T7 RNA polymerase, primer extension with engineered DNA polymerases, or 3′‐labelling with poly(A) polymerase are used for enzymatic synthesis of base‐modified RNA.
Ugnė Šinkevičiūtė   +5 more
wiley   +1 more source

High‐Resolution Molecular‐Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2)

open access: yesChemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.
Producing more than 6 μs of cumulated simulation time with the AMOEBA polarizable force field, we determined key structural properties of the PKM2 (catalytic, FBP and TEPP) and PKM1 enzymes binding sites to determine new cryptic pockets for further antiviral/antitumoral drug design.
Quentin Delobelle   +6 more
wiley   +1 more source

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

open access: yes
Cancer Communications, EarlyView.
Lea Järke   +15 more
wiley   +1 more source

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