Results 291 to 300 of about 253,092 (356)

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug-Target Interaction Deep Learning-Based Model. [PDF]

Curr Issues Mol Biol
Chun H, Lee H, Kim J, Yeo H, Hyung K, Song D, Kim M, Jun SH, Kang NG.   +8 more
europepmc   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

ChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber, Solomon Kojo Attionu, Theodore Kwaku Dayie, Christoph Kreutz   +3 more
wiley   +1 more source

Adenosine triphosphate induces amorphous aggregation of amyloid β by increasing Aβ dynamics. [PDF]

Sci Rep
Kuramochi M, Nakamura M, Takahashi H, Komoriya T, Takita T, Pham NTK, Yasukawa K, Yoshimune K.   +7 more
europepmc   +1 more source

Kinetic Studies Reveal that the Secondary Station Impacts the Rate of Motion of Cyclobis(Paraquat‐p‐Phenylene) in Out‐of‐Equilibrium [2]Rotaxanes

ChemPlusChem, EarlyView.
Bistable [2]rotaxanes, that incorporate monopyrrolotetrathiafulvalene (MPTTF) as the primary station (green) and either hydroquinone (HQ) or xylyl (XY) as the secondary station (red) for the cyclobis(paraquat‐p‐phenylene) ring (blue), can be pushed out of equilibrium and spectroscopic studies carried out on the isolated high‐energy metastable co ...
Mathias S. Neumann, Sofie K. Jensen, Rikke Frederiksen, Sissel S. Andersen, Kasper M. Beck, Jan O. Jeppesen   +5 more
wiley   +1 more source

Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

Drug Testing and Analysis, EarlyView.
The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou, Adam Cawley, Glenys Noble, Jaymie Loy, David Bishop, John Keledjian, Kireesan Sornalingam, Stacey Richards, Shanlin Fu   +8 more
wiley   +1 more source

Fisetin is a selective adenosine triphosphate-competitive inhibitor for mitogen-activated protein kinase kinase 4 to inhibit lipopolysaccharide-stimulated inflammation. [PDF]

Biofactors
He Z, Uto T, Tanigawa S, Sakao K, Kumamoto T, Xie K, Pan X, Wu S, Yang Y, Komatsu M, Hou DX.   +10 more
europepmc   +1 more source

Predicting global intraspecific trait variation of grasses

Ecography, EarlyView.
Plant traits are important for understanding community assembly and ecosystem processes, yet our understanding of intraspecific trait variation (ITV) is limited. This gap in our knowledge is partially because collecting trait data across a species' entire range is impractical, let alone across the ranges of multiple species within a plant family. Using
Robert J. Griffin‐Nolan, Maria S. Vorontsova, Brody Sandel   +2 more
wiley   +1 more source

Role of Exogenous Pyruvate in Maintaining Adenosine Triphosphate Production under High-Glucose Conditions through PARP-Dependent Glycolysis and PARP-Independent Tricarboxylic Acid Cycle. [PDF]

Int J Mol Sci
Yako H, Niimi N, Takaku S, Kato A, Kato K, Sango K.   +5 more
europepmc   +1 more source

Stoichiometry and Localization of Adenosine Triphosphate-dependent Sodium and Potassium Transport in the Erythrocyte

, 1964
Amar K. Sen, Robert L. Post
openalex   +1 more source