Results 321 to 330 of about 253,092 (356)

Compound heterozygosity of a De novo 16q24.1 deletion and missense mutation in COX4I1 leads to developmental regression, intellectual disability, and seizures

Epilepsia Open, EarlyView.
Abstract The COX4I1 is responsible for encoding a crucial component of cytochrome c oxidase, integral to electron transport in the mitochondrial respiratory chain. Mutations in COX4I1 can result in a rare autosomal recessive disorder characterized by growth retardation, slow weight gain, microcephaly, and potentially, hematologic symptoms such as ...
Zhen Liu, Mei He, Xuan Luo, Hu Pan, Xiao Mao, Jinping Su   +5 more
wiley   +1 more source

Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer

Exploration, EarlyView.
Considering the rapid progression of cancer in most cases, any delay in evaluating therapy outcomes poses a significant threat to patients’ lives. Consequently, it is imperative to implement stratification and conduct timely evaluations of therapeutic effects either before or during the early stages of cancer treatment.
Qinrui Fu
wiley   +1 more source

Adenosine Triphosphate Mediates Phase Separation of Disordered Basic Proteins by Bridging Intermolecular Interaction Networks. [PDF]

J Am Chem Soc
Kota D, Prasad R, Zhou HX.
europepmc   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy

Exploration, EarlyView.
Self‐assembled S‐Cu(I)‐S sites were spatially isolated onto a two‐dimensional Ti3C2 surface to produce a structurally well‐defined and highly functional single‐site copper(I) nanomodulator CuNTD, which can induce severe immunogenic cell death through multiple regulatory pathways of synergistic cascade photothermal‐amplified ROS storms, cuproptosis and ...
Yuanyuan Zhang, Shengnan Ya, Jingnan Huang, Yangyang Ju, Xueyang Fang, Xinteng Ouyang, Qingdong Zeng, Xinyao Zhou, Xiyun Yan, Guohui Nie, Kelong Fan, Bin Zhang   +11 more
wiley   +1 more source

Assessment of endoscope reprocessing at World Gastroenterology Organisation training centers using adenosine triphosphate testing. [PDF]

Endosc Int Open
Visrodia K, Jones D, Jennings M, Conway C, Burgos H, Malani J, Ogutu E, Pausawasdi N, Sabbagh L, Leddin D, Kassmeyer B, Lennon RJ, Topazian MD.   +12 more
europepmc   +1 more source

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core‐Shell Manganese Phosphate/siPD‐L1 Modulator

Exploration, EarlyView.
To enhance the comprehensive treatment effect of triple‐negative breast cancer, a pH‐responsive core‐shell manganese phosphate nano‐regulator was prepared to reprogram the tumor microenvironment bi‐directionally. (1) “Brakes off”: Using siPD‐L1 to inhibit PD‐L1 expression to restore CD8+ T cell function.
Fei Xia, Yuqian Lu, Zipeng Gong, Qingchao Tu, Shuntao Liang, Chen Wang, HaiLu Yao, LinYing Zhong, Yuanfeng Fu, Pengbo Guo, Yichong Hou, Xinyu Zhou, Li Zou, Licheng Gan, Weiqi Chen, Jiawei Yan, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Chen Pan, Xiaomei Tao, Jigang Wang, Qingfeng Du, Chong Qiu   +24 more
wiley   +1 more source

Overcoming Toxicity Barriers for Boosting Nisin Synthesis in Lactococcus lactis Strain via Adaptive Laboratory Evolution

Food Chemistry International, EarlyView.
After adaptive laboratory evolution against nisin, improved nisin production and tolerance were found in the evolved strains. To reveal the advantages of the evolved strains, a systematic comparison was made between the starting strains and the domesticated strains in terms of their microscopic morphology, metabolomics, transcriptomics, and whole ...
Xinyue Liu, Yuwei Sun, Jiang Zhu, Fang Wang, Zhijia Liu, Yanfei Wang, Shengbao Cai, Junjie Yi   +7 more
wiley   +1 more source

The dynamic relationship between inorganic polyphosphate and adenosine triphosphate in human non-small cell lung cancer H1299 cells. [PDF]

FEBS Open Bio
Tsutsumi K, Tippayamontri T, Hayashi M, Matsuda N, Goto Y.   +4 more
europepmc   +1 more source

The Effect of Oral Adenosine Triphosphate (ATP) Supplementation on Anaerobic Exercise in Healthy Resistance-Trained Individuals: A Systematic Review and Meta-Analysis. [PDF]

Sports (Basel)
González-Marenco R, Estrada-Sánchez IA, Medina-Escobedo M, Chim-Aké R, Lugo R.   +4 more
europepmc   +1 more source