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Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner. [PDF]
J Innate ImmunMaler MD +19 more
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Long-Term Dynamic Changes in Hybrid Immunity over Six Months after Inactivated and Adenoviral Vector Vaccination in Individuals with Previous SARS-CoV-2 Infection. [PDF]
Vaccines (Basel)Suntronwong N +15 more
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Biosafety of Adenoviral Vectors
Current Gene Therapy, 2003Adenoviral vectors can efficiently transduce a broad variety of different cell types and have been used extensively in preclinical and clinical studies. However, early generation of adenoviral vectors retained residual adenoviral genes that contribute to inflammatory immune responses and toxicity.
Chuah, Marinee K L +2 more
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Construction of Adenoviral Vectors
Molecular Biotechnology, 2001Recombinant adenovirus vectors have proven to be useful tools in facilitating gene transfer. Construction of such vectors requires a knowledge of the adenovirus genome structure and its life cycle. A commonly used recombinant adenovirus involves deletion of the E1 region; such a recombinant is traditionally produced by overlap recombination after ...
A R, Davis +4 more
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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
Replication-defective vectors based on human adenovirus serotypes 2 and 5 (Ad2 and Ad5) possess a number of attributes which favor their use as gene delivery vehicles in gene therapy applications. However, the widespread distribution of the primary cellular receptor for Ad, the coxsackievirus and adenovirus receptor (CAR), allows Ad vectors to infect a
Brian G, Barnett +2 more
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Replication-defective vectors based on human adenovirus serotypes 2 and 5 (Ad2 and Ad5) possess a number of attributes which favor their use as gene delivery vehicles in gene therapy applications. However, the widespread distribution of the primary cellular receptor for Ad, the coxsackievirus and adenovirus receptor (CAR), allows Ad vectors to infect a
Brian G, Barnett +2 more
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Applied Biochemistry and Biotechnology, 2006
Gene therapy is a promising tool for treatment of the human diseases that cannot be cured by rational therapies, and its primary success depends on suitable vectors to deliver therapeutic genes. Adenoviruses (Ads) are among the most commonly used vectors for gene therapy, second only to retroviruses. During the last decade, remarkable progress has been
Siddhartha S, Ghosh +2 more
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Gene therapy is a promising tool for treatment of the human diseases that cannot be cured by rational therapies, and its primary success depends on suitable vectors to deliver therapeutic genes. Adenoviruses (Ads) are among the most commonly used vectors for gene therapy, second only to retroviruses. During the last decade, remarkable progress has been
Siddhartha S, Ghosh +2 more
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Current Protocols in Human Genetics, 2004
AbstractAdenoviral vectors have been widely used as efficient gene delivery vehicles for gene therapy and vaccine development, as well as gene function studies. The recently developed AdEasy system is a simple and efficient method for rapid generation of recombinant adenoviruses.
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AbstractAdenoviral vectors have been widely used as efficient gene delivery vehicles for gene therapy and vaccine development, as well as gene function studies. The recently developed AdEasy system is a simple and efficient method for rapid generation of recombinant adenoviruses.
openaire +2 more sources
2003
It is important to analyze to what extent these random or designed mutations abrogate viral replication in normal cells because a tightly controlled vector could be injected at higher doses intratumorally or even systemically. On the other hand, it is also important to analyze to what extent these mutations affect the amount of virus produced per ...
R, Alemany, W W, Zhang
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It is important to analyze to what extent these random or designed mutations abrogate viral replication in normal cells because a tightly controlled vector could be injected at higher doses intratumorally or even systemically. On the other hand, it is also important to analyze to what extent these mutations affect the amount of virus produced per ...
R, Alemany, W W, Zhang
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Helper‐Dependent Adenoviral Vectors
Current Protocols in Human Genetics, 2004AbstractThe helper‐dependent adenovirus (HDAd) is a recently developed adenovirus‐based vector with an improved safety profile and long‐term transgene expression. In this unit, a basic procedure for HDAd production using the Cre‐loxP system is presented.
Kazuhiro, Oka, Lawrence, Chan
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