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Adenoviral vectors for gene transfer
Current Opinion in Biotechnology, 1997Adenoviruses began to be developed into highly effective gene expression vectors in the early 1980s. Recently, the increased interest in utilizing this transfer system in vivo has posed new problems for heterologous gene-transfer, spurring a renewed effort in the field of vector development toward solving the structural, immunological and targeting ...
I, Kovesdi +3 more
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Adenoviral vectors for gene therapy
Molecular Biotechnology, 2007Vectors based on human adenovirus serotypes 2 (Ad2) and 5 (Ad5) of species C possess a number of features that have favored their widespread employment for gene delivery both in vitro and in vivo. However, the use of recombinant Ad2- and Ad5-based vectors for gene therapy also suffers from a number of disadvantages. These vectors possess the tropism of
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Adenoviral vectors: development and application
Expert Opinion on Investigational Drugs, 1997One of the prerequisites for the successful application of gene vaccination and therapy is the development of efficient gene delivery vectors. The rate-limiting nature of vectors was clearly manifested during the first wave of gene therapy testing, resulting in the demand for more effective and suitable vector systems.
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Adenoviral vectors – new insights
Trends in Microbiology, 2000I apologize to my colleagues for any omissions in this short report owing to space limitations.
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HPLC Purification of Adenoviral Vectors
2009Adenoviruses are attractive vectors for gene therapy where short-term transgene expression is required. In order to meet the clinical requirements of adenovirus for use beyond the laboratory, advanced methods are required for the purification and quantitation of recombinant adenoviral vectors (rAd).
Marc, Eglon +2 more
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