Results 91 to 100 of about 314,751 (339)
Postgraduate Medical Journal, 1973 Summary Ninety-three adenoviruses were found in the MRC/PHLS survey of patients in general practice and eighty-eight in those admitted to hospital, types 1, 2, 3, 5 and 7 being the most frequent ones isolated. The adenoviruses accounted for 11% and 12% of all viruses and were present in 2% and 4% of patients examined in these surveys ...
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Advanced Science, EarlyView.Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu +9 more
wiley +1 more source
Mitochondrial DNA from hamster tumors induced by adenovirus type 12 [PDF]
, 1970 1. Mitochondria isolated from hamster tumors induced by adenovirus type 12 possessed circular DNA fibers. 2. The mean value of the length of the highest frequency group of the circular DNA molecules was 4.92 ±0.38 μ. 3. Catenated dimer DNA molecules
Nishida, Shigeru, Oda, Takuzo
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Adenovirus signalling in entry [PDF]
Cellular Microbiology, 2012 Viruses carry nucleic acids between and within host cells. Invariably, virus attachment to host cells leads to activation of cell signalling. These so-called forward signals emerge from interactions with cell surface receptors or cytosolic proteins and elicit profound responses in the cells, for example induction of growth or innate immunity responses.
Wolfrum Nina, Greber Urs F
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Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow
Advanced Science, EarlyView.DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
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Molecular Therapy: Methods & Clinical Development, 2020 To ensure the high purity and biological activity of the adenovirus vector to be used for clinical applications, a stable and linearly scalable preparation method is highly imperative.
Jinhu Ma +11 more
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Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior [PDF]
, 2017 Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V).
Barahona, María José +10 more
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TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, EarlyView.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Screening for the optimal siRNA targeting a novel gene (HA117) and construction and evaluation of a derivative recombinant adenovirus [PDF]
, 2010 We found a novel gene named as HA117 in our previous research. At this study, we screened for an optimal siRNA targeting the novel gene HA117 using the pSOS-HUS method, verified the results of pSOS-HUS siRNA screening for optimal affinity for the target ...
Gaihuan Zheng +4 more
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Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]
, 2009 Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo +37 more
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