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Of the 53 different human adenovirus (HAdV) serotypes belonging to species A-G, a significant number are associated with acute respiratory, gastrointestinal and ocular infections. Replication-defective HAdV-5-based vectors also continue to play a significant role in gene transfer trials and in vaccine delivery efforts in the clinic.
Jason G, Smith +3 more
openaire +4 more sources
Determining new functions of Adenovirus VA-RNAI and its use in cancer therapy [PDF]
PhDVirus-Associated RNA I (VA-RNAI; VAI) of adenovirus is a nontranslated RNA molecule known to interact with several dsRNA-binding molecules in host cells.
Binny, Christopher Jonathan
core +4 more sources
Background Human adenovirus can cause morbidity and mortality in immunocompromised patients after allogeneic stem cell transplantation. Reconstitution of adenovirus-specific CD4+ T cells has been reported to be associated with sustained protection from ...
Maarten L. Zandvliet +12 more
doaj +1 more source
Background: Human adenovirus (HAdV) is one of the most common viruses causing respiratory infections among young children. Most adenovirus infections are mild and self-limited; however, these infections may occasionally cause severe pneumonia and even ...
Xue-Hua Xu +6 more
doaj +1 more source
Brain tumors induced in rats by human adenovirus type 12 [PDF]
Oncogenesis of human adenovirus type 12 in the brain of rats was examined. Newborn rats of Sprague-Dawley and Donryu strains were injected intracranially with human adenovirus type 12. The incidence of intracranial tumors was 91% (30/33) in
Ogawa, Katsuo +5 more
core +1 more source
Adenovirus and its interaction with host cell proteins [PDF]
The E1B55k gene in adenovirus type 5 was studied by generating recombinant viruses in which the E1B55k gene was N-terminally tagged with either a cyan fluorescent protein (CFP) tag or a tandem affinity purification (TAP) tag.
Carr, Sharon
core +2 more sources
Enteric adenovirus associated with acute gastroenteritis among hospitalized and healthy childern under five - years of age in Basrah, Iraq [PDF]
Background: Enteric Adenovirus are second to rotavirus as viral cause of acute gastroenteritis in infants and young children. Aims of the study: This study aimed on determination of the incidence of enteric adenovirus-associated gastroenteritis in ...
Hazim Thewainy, Hassanf Hasony
doaj +1 more source
ABSTRACTAdenoviruses are a highly prevalent infection that can cause a range of clinical syndromes in immunocompromised patients, ranging from localized disease of the respiratory tract, gastrointestinal tract, or urinary tract to disseminated disease.
Michael G, Ison, Randall T, Hayden
openaire +2 more sources
Assessment and development of adenovirus type 11 for cancer therapy [PDF]
PhDThe efficacy of oncolytic virotherapy is influenced by the interactions between the tumour, virus and host immunity. The first generation of oncolytic adenoviruses, based on serotype 5 (Ad5), has achieved limited success in clinical trials.
Wong, Han Hsi
core +4 more sources
Background Adenovirus are the important pathogen of pediatric severe pneumonia. The aim of this study is to analyze the infection, subtype and distribution of adenovirus in autopsied pulmonary tissue of fatal pneumonia in infants and children, and the ...
Gong Si-Tang +9 more
doaj +1 more source

