Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy [PDF]
Viruses, 2021 Gene therapy is currently in the public spotlight. Several gene therapy products, including oncolytic virus (OV), which predominantly replicates in and kills cancer cells, and COVID-19 vaccines have recently been commercialized. Recombinant adenoviruses,
Maki Watanabe +3 more
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Cytokine Responses to Adenovirus and Adenovirus Vectors
Viruses, 2022 The expression of cytokines and chemokines in response to adenovirus infection is tightly regulated by the innate immune system. Cytokine-mediated toxicity and cytokine storm are known clinical phenomena observed following naturally disseminated ...
Svetlana Atasheva +1 more
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Pediatrics In Review, 2010 Of the 53 different human adenovirus (HAdV) serotypes belonging to species A-G, a significant number are associated with acute respiratory, gastrointestinal and ocular infections. Replication-defective HAdV-5-based vectors also continue to play a significant role in gene transfer trials and in vaccine delivery efforts in the clinic.
Jason G, Smith +3 more
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Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model. [PDF]
, 2016 Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in ...
Bouvet, Michael +10 more
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Frontiers in Pediatrics, 2021 Objectives: To identify the differences of clinical characteristics and outcomes of severe pneumonia in children under 5 years old with and without adenovirus infection.Methods: A retrospective cohort study was conducted in three pediatric hospitals in ...
Lingling Zheng +8 more
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Pandemic influenza virus 2009 H1N1 and adenovirus in a high risk population of young adults: epidemiology, comparison of clinical presentations, and coinfection. [PDF]
PLoS ONE, 2014 BACKGROUND: In 2009, pandemic H1N1 influenza virus (2009 H1N1) emerged worldwide, causing morbidity and mortality that disproportionately affected young adults.
Heather C Yun +5 more
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A novel psittacine adenovirus identified during an outbreak of avian chlamydiosis and human psittacosis: zoonosis associated with virus-bacterium coinfection in birds. [PDF]
PLoS Neglected Tropical Diseases, 2014 Chlamydophila psittaci is found worldwide, but is particularly common among psittacine birds in tropical and subtropical regions. While investigating a human psittacosis outbreak that was associated with avian chlamydiosis in Hong Kong, we identified a ...
Kelvin K W To +14 more
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Adenovirus Core Proteins: Structure and Function
Viruses, 2021 Adenoviruses have served as a model for investigating viral-cell interactions and discovering different cellular processes, such as RNA splicing and DNA replication.
Shermila Kulanayake, Suresh K. Tikoo
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Altering the Ad5 packaging domain affects the maturation of the Ad particles. [PDF]
PLoS ONE, 2011 We have previously described a new family of mutant adenoviruses carrying different combinations of attB/attP sequences from bacteriophage PhiC31 flanking the Ad5 packaging domain.
Raul Alba +5 more
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Seminars in Respiratory and Critical Care Medicine, 2011 Adenoviruses (AdV) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal (GI) tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or encephalitis.
Lynch, Joseph P. +2 more
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