Results 41 to 50 of about 291,962 (341)

Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety. [PDF]

PLoS ONE, 2015
Subconjunctival injection is a minimally invasive route for gene delivery to ocular tissues, but has traditionally been limited to use in the cornea. The accurate ocular distribution of virus has not, however, been previously investigated.
Guei-Sheung Liu, Jiang-Hui Wang, Jia Hui Lee, Pei-Jhen Tsai, Han-En Tsai, Shwu-Jiuan Sheu, Hsiu-Chen Lin, Gregory J Dusting, Ming-Hong Tai, Youn-Shen Bee   +9 more
doaj   +1 more source

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

New England Journal of Medicine, 2011
BACKGROUND Hemophilia B, an X-linked disorder, is ideally suited for gene therapy. We investigated the use of a new gene therapy in patients with the disorder.
A. Nathwani, E. Tuddenham, S. Rangarajan, Cecilia Rosales, J. McIntosh, D. Linch, P. Chowdary, A. Riddell, Arnulfo Pie, C. Harrington, J. O'Beirne, Keith A. Smith, J. Pasi, B. Glader, P. Rustagi, C. Ng, M. Kay, Jun-Fang Zhou, Yunyu Spence, Christopher L. Morton, James A. Allay, J. Coleman, S. Sleep, J. Cunningham, D. Srivastava, E. Basner-Tschakarjan, F. Mingozzi, K. High, J. Gray, U. Reiss, A. Nienhuis, A. Davidoff   +31 more
semanticscholar   +1 more source

Examen de adenovirus con métodos moleculares y patológicos en casos de pneumonía ovina

Revista Mvz Cordoba, 2022
Objetivo. Revelar adenovirus (AdV) que causan pneumonía en ovejas y examinar cambios patológicos en los ganglios linfáticos pulmonares y mediastínicos de muestras positivas para adenovirus infectadas de forma natural. Material y métodos.
Muhammet Bahaeddin Dörtbudak, Yavuz Selim Sağlam, Serkan Yıldırım, Mehmet Özkan Timurkan   +3 more
doaj   +1 more source

Pediatric acute gastroenteritis due to adenovirus 40/41 in low- and middle-income countries

Current Opinion in Infectious Diseases, 2020
Purpose of review To review the roles of enteric adenovirus types 40 and 41 and nonenteric adenoviruses in the global burden of pediatric diarrhea.
Benjamin Lee, Christina F. Damon, J. Platts-Mills   +2 more
semanticscholar   +1 more source

Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province, China

Virology Journal, 2011
Background Pneumonia caused by adenovirus infection is usually severe especially with adenovirus serotype 7 commonly associated with lower respiratory tract disease outbreaks.
Xu Wenbo, Wang Li, Tan Xiaojuan, Tang Liuying   +3 more
doaj   +1 more source

AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes

Scientific Reports, 2023
Efficient manufacture of recombinant adeno-associated virus (rAAV) vectors for gene therapy remains challenging. Packaging cell lines containing stable integration of the AAV rep/cap genes have been explored, however rAAV production needs to be induced ...
Weiheng Su, Leonard W. Seymour, Ryan Cawood   +2 more
doaj   +1 more source

Direct in vivo gene transfer to the airway epithelium employing adenovirus-polylysine-DNA complexes [PDF]

, 1993
Adenovirus-polylysine-DNA complexes were evaluated for their capacity to accomplish direct in vivo gene transfer to airway epithelium employing a rodent model.
Miller, L., Rømer, M., Wagner, E., Harris, C. E., Hu, P.-C., Wagner, Ernst, Cotten, Matt, Cotten, M., Agarwal, Santosh, Curiel, David T., Agarwal, S., Gao, L., Harris, C., Romer, M., Curiel, D.   +14 more
core   +1 more source

Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient

BMC Infectious Diseases, 2018
Background We report a fatal case of disseminated adenovirus infection in a non-transplant haematology adult patient with chronic lymphocytic leukaemia who had completed combination chemoimmunotherapy a few months before developing respiratory symptoms ...
Michael Joffe, Simon D. Wagner, Julian W. Tang   +2 more
doaj   +1 more source

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X [PDF]

, 2010
Human adenoviruses from multiple species bind to coagulation factor X (FX), yet the importance of this interaction in adenovirus dissemination is unknown.
Angela C Bradshaw, Duffy, Margaret R., Andrew H. Baker, Lynda Coughlan, Coughlan Lynda, Baker Andrew H., van Rooijen, Nico, van Rooijen, N., Nicklin, Stuart A., Margaret R Duffy, Parker, A.L., Kahari, V.M., Alan L Parker, Kähäri Veli-Matti, Stuart A Nicklin, Nico van Rooijen, Andrew H Baker, Coughlan, L., Nicklin Stuart A., Coughlan, Lynda, Kahari, Veli-Matti, Duffy, M.R., Parker Alan L., Bradshaw Angela C., Parker, Alan L., Duffy Margaret R., Bradshaw, Angela C., Bradshaw, A.C., Veli-Matti Kähäri, Angela C. Bradshaw, Alan L. Parker, Margaret R. Duffy, Stuart A. Nicklin, Baker, Andrew H., Baker, A.H., Nicklin, S.A., van Rooijen Nico   +36 more
core   +2 more sources

The Revolving Door of Adenovirus Cell Entry: Not All Pathways Are Equal

Pharmaceutics, 2021
Adenoviruses represent exceptional candidates for wide-ranging therapeutic applications, from vectors for gene therapy to oncolytics for cancer treatments.
Davor Nestić, Ksenija Božinović, Isabela Pehar, Rebecca Wallace, Alan L. Parker, Dragomira Majhen   +5 more
doaj   +1 more source