Results 61 to 70 of about 291,962 (341)
陆军军医大学学报, 2023 Objective To explore the effect and mechanism of zinc finger protein A20 in the nucleus pulposus cells of intervertebral disc with hypoxic conditions.
GUO Shuaichi +4 more
doaj +1 more source
Viral and Cellular Interactions During Adenovirus DNA Replication
FEBS Letters, 2019 Adenoviruses represent ubiquitous and clinically significant human pathogens, gene‐delivery vectors, and oncolytic agents. The study of adenovirus‐infected cells has long been used as an excellent model to investigate fundamental aspects of both DNA ...
Matthew Charman +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Evolution and diversity of human adenoviruses isolated from patients with keratoconjunctivitis
Iranian Journal of Microbiology, 2022 Background and Objectives: Human adenovirus type 8 is a highly contagious eye disease and is considered as the most common epidemic keratoconjunctivitis worldwide.
Chiman Karami +7 more
doaj
Innate immunity to adenovirus: lessons from mice.
FEBS Letters, 2019 Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the animal kingdom, infecting hosts ranging from lizards and frogs to dolphins, birds, and humans.
Svetlana Atasheva +2 more
semanticscholar +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Covalent decoration of adenovirus vector capsids with the carbohydrate epitope αGal does not improve vector immunogenicity, but allows to study the in vivo fate of adenovirus immunocomplexes. [PDF]
PLoS ONE, 2017 Adenovirus-based vectors are promising tools for genetic vaccination. However, several obstacles have to be overcome prior to a routine clinical application of adenovirus-based vectors as efficacious vectored vaccines.
Ramona F Kratzer +4 more
doaj +1 more source
Postgraduate Medical Journal, 1973 Summary Ninety-three adenoviruses were found in the MRC/PHLS survey of patients in general practice and eighty-eight in those admitted to hospital, types 1, 2, 3, 5 and 7 being the most frequent ones isolated. The adenoviruses accounted for 11% and 12% of all viruses and were present in 2% and 4% of patients examined in these surveys ...
openaire +2 more sources
Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]
, 1994 Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Cotten, M. +7 more
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source