Results 131 to 140 of about 122,429 (294)

The transmembrane domain of the adenovirus E3/19K protein acts as an ER retention signal and contributes to intracellular sequestration of MHC class I molecules [PDF]

, 2013
The human adenovirus E3/19K-protein is a type-I transmembrane glycoprotein of the endoplasmic reticulum (ER) that abrogates cell-surface transport of MHC class-I (MHC-I) and MICA/B-molecules.
Ruszics, Zsolt, Burgert, Hans-Gerhard, Mackley, Emma, Sester, Martina   +3 more
core  

Prostate cancer targeting using replication-selective adenoviruses in combination with phytochemicals

, 2009
PhD 2009 QMOncolytic adenoviral mutants have demonstrated good safety profiles but, despite some encouraging clinical results, efficacy as a single agent was limited. Combinations with conventional chemo- or radiotherapy significantly enhanced the anti-
Adam, Virginie Sarah
core  

Severe Adenovirus Pneumonia Masked by Influenza Virus in an 11-Year-Old Child: A Case Report

Infection and Drug Resistance
Yi Shi, Yifan Ren Department of Pediatrics, Shaoxing Keqiao Women and Children’s Hospital, Shaoxing, Zhejiang Province, People’s Republic of ChinaCorrespondence: Yi Shi, Email shiyi111002@163.comBackground: Adenovirus pneumonia progresses rapidly, with a
Shi Y, Ren Y
doaj  

Modification of the E1-pIX region of the adenovirus 5 genome for use in cancer gene therapy

, 2008
Currently the use of adenoviruses in cancer gene therapy is limited by efficient delivery of the virus into the tumour cells, detargeting of the virus from the liver, and the efficient spread of the virus within the tumour.
Kallioinen, Susanna E.
core  

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Bioprocessing of oncolytic group B adenovirus for scalable production

, 2014
The central aim of this thesis was to develop strategies to improve the manufacture of the group B chimeric oncolytic adenovirus, ColoAd1, which rapidly kills and lyses host cells.
Lisa May Cooper, Cooper, Lisa May
core   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

COMBINED APPLICATION OF OKOMISTIN® И OFTALMOFERON® EYE DROPS IN TREATMENT OF ADENOVIRAL CONJUNCTIVITIS

Офтальмохирургия, 2015
Purpose. To evaluate the clinical efficacy of a combined application of Okomistin and Oftalmoferon compared to an Oftalmoferon monotherapy in the treatment of viral conjunctivitis. Material and methods.
V. V. Pozdnyakova, E. V. Yani, D. E. Tokarev   +2 more
doaj  

Rotavirus and adenovirus infections in children with acute gastroenteritis after introducing the Rotasiil® vaccine in Kisangani, Democratic Republic of the Congo.

PLoS ONE
BackgroundAlthough rotavirus vaccination has reduced the global burden of the virus, morbidity and mortality from rotavirus infection remain high in Sub-Saharan Africa.
Didier Gbebangi Manzemu, Jean Pierre Alworong'a Opara, Emmanuel Tebandite Kasai, Mupenzi Mumbere, Véronique Muyobela Kampunzu, Bibi Batoko Likele, Naura Apio Uvoya, Hortense Malikidogo Vanzwa, Gaspard Mande Bukaka, Falay Sadiki Dady, Nestor Ngbonda Dauly, Laurent Belec, Serge Tonen-Wolyec   +12 more
doaj   +1 more source

Suppression of RNA interference by adenovirus virus-associated RNA

, 2005
We show that human adenovirus inhibits RNA interference (RNAi) at late times of infection by suppressing the activity of two key enzyme systems involved, Dicer and RNA-induced silencing complex (RISC).
B. Berkhout, M. G. Andersson, P. C. J. Haasnoot, S. Berenjian, Haasnoot, P C Joost, Berkhout, Ben, Akusjärvi, Göran, G. Akusjarvi, Andersson, M. Gunnar, Berenjian, Saideh, Akusjärvi, Göran,, Andersson, M Gunnar,, Xu, Ning, Berenjian, Saideh,, Haasnoot, P. C. Joost, N. Xu, Xu, Ning,   +16 more
core   +1 more source