Results 61 to 70 of about 122,429 (294)

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age

Журнал инфектологии, 2014
In recent years, examines the role of viral infection in the development of IgA-nephropathy. In our study, an analysis of renal biopsy tissue from 17 patients IgA-nephropathy in the presence of adenoviral antigen.
I. A. Rakityanskaya, T. S. Ryabova
doaj   +1 more source

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo [PDF]

, 2008
The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with adenoviral vectors.
György Fejer, Hildenbrand, B., Schleicher, U, Hildenbrand, Bernd, Marina A Freudenberg, Fejer, G., Greber, U., Ruzsics, Zsolt, Drechsel, Lisa, Fejer György, Imelli, N., Imelli, N, Ruzsics, Z., Krug Anne, Christian Bogdan, Keck, S., Zsolt Ruzsics, Lisa Drechsel, Hildenbrand Bernd, Drechsel, L., Simone Keck, Schleicher, Ulrike, Bogdan, C, Liese, J., Freudenberg, M., Bogdan, C., Schleicher Ulrike, Bogdan Christian, Ulrike Schleicher, Keck Simone, Krug, A., Fejer, György, Schleicher, U., Bogdan, Christian, Greber Urs F., Freudenberg, M A, Nicola Imelli, Krug, A, Greber, Urs F., Drechsel Lisa, Keck, S, Liese Jan, Krug, Anne, Jan Liese, Drechsel, L, Ruzsics, Z, Ruzsics Zsolt, Hildenbrand, B, Imelli, Nicola, Freudenberg, Marina A., Freudenberg Marina A., Bernd Hildenbrand, Urs F Greber, Fejer, G, Liese, J, Keck, Simone, Anne Krug, Greber, U F, Imelli Nicola, Liese, Jan   +59 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary cells in the presence of adenovirus [PDF]

, 1994
Endotoxin (lipopolysaccharide, LPS) is commonly found as a contaminant in plasmid DNA preparations. We demonstrate here that the quantities of LPS typically contaminating DNA preparations can generate a toxicity to primary cells (primary human skin ...
Cotten, M., Buschle, M., Wagner, E., Saltik, M., Wagner, Ernst, Cotten, Matt, Baker, A., Saltik, Mediyha   +7 more
core  

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011.

PLoS ONE, 2013
ObjectiveIncreased incidence of adenovirus infection in children was noticed since September 2010 in Taiwan and severe cases requiring intensive care were noted later.
Chen-Yin Lai, Chia-Jie Lee, Chun-Yi Lu, Ping-Ing Lee, Pei-Lan Shao, En-Ting Wu, Ching-Chia Wang, Boon-Fatt Tan, Hsin-Yu Chang, Shao-Hsuan Hsia, Jainn-Jim Lin, Luan-Yin Chang, Yhu-Chering Huang, Li-Min Huang, Taiwan Pediatric Infectious Disease Alliance   +14 more
doaj   +1 more source

Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation [PDF]

, 2018
Human adenovirus (HAdV) infections are well-described after hematopoietic stem cell transplantation but less well understood in solid organ transplantation (SOT).
Vinod K. Prasad, Gray, G. C., Marion Hemmersbach-Miller, Matthew Kappus, Hemmersbach-Miller, Marion, Gregory C. Gray, Hemmersbach-Miller, M., Alspaugh, J Andrew, Bailey, E. S., Prasad, V. K., Kappus, M., Emily S. Bailey, Gray, Gregory C, Kappus, Matthew, Bailey, Emily S, J. Andrew Alspaugh, Alspaugh, A., Prasad, Vinod K   +17 more
core   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source