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Biochemistry, 2014
Photoactivated adenylyl cyclases are powerful tools for optogenetics and for investigating signal transduction mechanisms in biological photoreceptors.
Manuela Stierl +4 more
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Photoactivated adenylyl cyclases are powerful tools for optogenetics and for investigating signal transduction mechanisms in biological photoreceptors.
Manuela Stierl +4 more
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Molecular and Cellular Biochemistry, 1991
Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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Hormone-sensitive adenylyl cyclase is a model system for the study of receptor-mediated signal transduction. It is comprised of three types of components: 1) receptors for hormones that regulate cyclic AMP (cAMP) synthesis, 2) regulatory GTP binding proteins (G proteins), and 3) the family of enzymes, the adenylyl cyclases.
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1993
Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
Natan Gollop +5 more
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Publisher Summary This chapter describes the enzyme (adenylyl cyclase) that effect the synthesis of Adenosine 3’,5’-cyclic monophosphate (cAMP) in various bacterial species. The content will rather reflect current major interests. The adenylyl cyclase from Escherichia coli has been a major subject of research interest ever since it was identified as ...
Natan Gollop +5 more
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American Journal of Respiratory Cell and Molecular Biology, 1999
Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Signal transduction via receptors that couple to guanine nucleotide binding proteins (G proteins) is pervasive throughout eukaryotic and prokaryotic biology. In humans, there are thought to be thousands of different G protein–coupled receptors (GPCRs), which carry out an amazingly diverse array of signaling, such as odorant detection, phototransduction,
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Dexras1 inhibits adenylyl cyclase
Biochemical and Biophysical Research Communications, 2004Dexras1 is a steroid hormone-induced Ras family G protein that acts as a receptor-independent activator of signaling by Gi/o family heterotrimeric G proteins. We examined the effects of Dexras1 on the activity of adenylyl cylase, a target of inhibitory regulation by Gialpha x GTP.
T.E. Graham, Z. Qiao, R.I. Dorin
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Conversion of a Guanylyl Cyclase to an Adenylyl Cyclase
Methods, 1999Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity.
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Adenylyl and Guanylyl Cyclase Assays
Current Protocols in Pharmacology, 2005AbstractThis unit presents two basic protocols to determine adenylyl cyclase and guanylyl cyclase activity in tissue and cell homogenates, permeabilized cells, or subcellular fractions. Each method is divided into two parts: the enzyme reaction that causes the formation of the labeled cyclic nucleotide, and the separation of cyclic nucleotide products ...
Troy Stevens +3 more
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2010
Publisher Summary This chapter presents the structure and catalytic mechanism of adenylyl cyclase (AC) and focuses on many modes of AC regulation. It also discusses normal and aberrant AC function in physiology and disease states. Hormonal and neurotransmitter regulation of AC occurs primarily through heterotrimeric G proteins in both vertebrates and ...
Roger K. Sunahara, Adam J. Kuszak
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Publisher Summary This chapter presents the structure and catalytic mechanism of adenylyl cyclase (AC) and focuses on many modes of AC regulation. It also discusses normal and aberrant AC function in physiology and disease states. Hormonal and neurotransmitter regulation of AC occurs primarily through heterotrimeric G proteins in both vertebrates and ...
Roger K. Sunahara, Adam J. Kuszak
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The adenylyl and guanylyl cyclase superfamily
Current Opinion in Structural Biology, 1998New structures solved in 1997 revealed that the adenylyl cyclase core consists of a pair of catalytic domains arranged in a wreath. Homologous catalytic domains are arranged in diverse adenylyl and guanylyl cyclases as symmetric homodimers or pseudosymmetric heterodimers.
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