Results 251 to 260 of about 102,595 (300)
Some of the next articles are maybe not open access.
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.
Science, 2000Spermatozoa undergo a poorly understood activation process induced by bicarbonate and mediated by cyclic adenosine 3',5'-monophosphate (cAMP). It has been assumed that bicarbonate mediates its effects through changes in intracellular pH or membrane ...
Yanqiu Chen +6 more
semanticscholar +1 more source
Photoaffinity Labeling of Adenylyl Cyclase
2002Photoaffinity is an effective tool to covalently tag amino acid residues that are in or near ligand-binding sites. The polypeptide chains that contribute to the binding site of a given receptor can be identified by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE) if they are specifically labeled with a radioactive marker ...
Gülhan Pilli +5 more
openaire +3 more sources
Purification of Soluble Adenylyl Cyclase
2002Cyclic AMP (cAMP), the nearly universal second messenger, is synthesized by a broad family of adenylyl cyclases (ACs). Mammals have at least nine isoforms of transmembrane-spanning adenylyl cyclases (tmACs). These differ in their expression patterns, and their catalytic activities are differentially regulated by G proteins and other signaling molecules.
Jochen Buck +2 more
openaire +3 more sources
Characterization and engineering of photoactivated adenylyl cyclases
Biological Chemistry, 2019Abstract Cyclic nucleoside monophosphates (cNMP) serve as universal second messengers in signal transduction across prokaryotes and eukaryotes. As signaling often relies on transiently formed microdomains of elevated second messenger concentration, means to precisely perturb the spatiotemporal dynamics of cNMPs are uniquely poised for ...
Birthe Stüven +5 more
openaire +4 more sources
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
Science, 1991Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)-bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.
Wei-Jen Tang, A. Gilman
semanticscholar +1 more source
Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases
Biochemistry, 2004Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a region homologous to protein kinases, followed by the C ...
Jaleel, Mahaboobi +2 more
openaire +2 more sources
Adenylyl cyclases as innovative therapeutic goals
Drug Discovery Today, 2009Pharmacological modulation of intracellular cyclic AMP (cAMP) signalling could provide new therapeutic and experimental tools. Although drugs interfering with this pathway have traditionally targeted membrane receptors, the effector enzyme adenylyl cyclase (AC), which functions as a signalling catalyst, also presents an interesting target.
PAVAN, Barbara +2 more
openaire +4 more sources
Regulation of adenylyl cyclase in LTP
Behavioral and Brain Sciences, 1995AbstractOur results on hippocampal long-term potentiation are considered in the context of Xia et al.'s hypothesis. Whereas the target article proposes presynaptic PKC involvement in adenylyl cyclase activation by phosphorylation of nenromodulin, we suggest an additional postsynaptic role involving RC3/nenrogranin.
Erik D. Roberson, J. David Sweatt
openaire +2 more sources
The regulatory diversity of the mammalian adenylyl cyclases
Current Opinion in Cell Biology, 1993Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca(2+)-amplified cAMP signals, synergism between Ca2+
Zhengui Xia +3 more
openaire +3 more sources
Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins
2009Die Bildung des Second Messengers cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz.
openaire +2 more sources