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Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases
Biochemistry, 2004Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a region homologous to protein kinases, followed by the C ...
Jaleel, Mahaboobi +2 more
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Adenylyl cyclases as innovative therapeutic goals
Drug Discovery Today, 2009Pharmacological modulation of intracellular cyclic AMP (cAMP) signalling could provide new therapeutic and experimental tools. Although drugs interfering with this pathway have traditionally targeted membrane receptors, the effector enzyme adenylyl cyclase (AC), which functions as a signalling catalyst, also presents an interesting target.
PAVAN, Barbara +2 more
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Regulation of adenylyl cyclase in LTP
Behavioral and Brain Sciences, 1995AbstractOur results on hippocampal long-term potentiation are considered in the context of Xia et al.'s hypothesis. Whereas the target article proposes presynaptic PKC involvement in adenylyl cyclase activation by phosphorylation of nenromodulin, we suggest an additional postsynaptic role involving RC3/nenrogranin.
Erik D. Roberson, J. David Sweatt
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The regulatory diversity of the mammalian adenylyl cyclases
Current Opinion in Cell Biology, 1993Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca(2+)-amplified cAMP signals, synergism between Ca2+
Zhengui Xia +3 more
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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins
2009Die Bildung des Second Messengers cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz.
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Chapter 64 Flagellar Adenylyl Cyclases in Chlamydomonas
1995Publisher Summary Gametic flagellar enzyme, but not the vegetative enzyme, is regulated by phosphorylation and dephosphorylation. Both the regulation by cell–cell interactions and the differences between the vegetative and gametic forms of the enzyme are matter of interest.
William J. Snell, Yuhua Zhang
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