Results 1 to 10 of about 30,514 (251)

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +4 more sources

β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator. [PDF]

PLoS ONE
Introductionβ-Nicotinamide adenine dinucleotide (β-NAD) is recognized as a sympathetic neurotransmitter that relaxes vascular and intestinal smooth muscle through purinergic receptor pathways. In the lung, β-NAD has been associated with anti-inflammatory
Innokentij Jurastow, Silke Wiegand, Amir Rafiq, Anna Zakrzewicz, Sandra Engel, Adriano Sanna, Daniel von der Beck, Walter Klepetko, Andreas Hecker, Andreas Günther, Moritz Bünemann, Gabriela Krasteva-Christ, Maryam Keshavarz   +12 more
doaj   +2 more sources

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Frontiers in Pharmacology, 2022
Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction in ...
Tiffany S. Dwyer, Joseph B. O’Brien, Christopher P. Ptak, Justin E. LaVigne, Daniel P. Flaherty, Daniel P. Flaherty, Daniel P. Flaherty, Val J. Watts, Val J. Watts, Val J. Watts, David L. Roman, David L. Roman, David L. Roman   +12 more
doaj   +2 more sources

The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i. [PDF]

PLoS ONE, 2016
Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxation of the peripheral arteries in part via release of nitric oxide (NO).
Peter Cseplo, Zoltan Vamos, Ivan Ivic, Orsolya Torok, Attila Toth, Akos Koller   +5 more
doaj   +4 more sources

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +2 more sources

Rosmarinic Acid Present in Lepechinia floribunda and Lepechinia meyenii as a Potent Inhibitor of the Adenylyl Cyclase gNC1 from Giardia lamblia [PDF]

Plants
Giardiasis is a parasitosis caused by Giardia lamblia with significant epidemiological and clinical importance due to its high prevalence and pathogenicity.
Adolfo Zurita, Esteban Vega Hissi, Agostina Cianci Romero, Adela María Luján, Sofía Salido, Agustín Yaneff, Carlos Davio, Justo Cobo, María Cecilia Carpinella, Ricardo Daniel Enriz   +9 more
doaj   +2 more sources

Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation [PDF]

Brazilian Journal of Medical and Biological Research, 2016
Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism.
O.A. López-Canales, M.C. Castillo-Hernandez, H. Vargas-Robles, A. Rios, J.S. López-Canales, B. Escalante   +5 more
doaj   +3 more sources

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +1 more source

Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. [PDF]

PLoS ONE, 2012
The most severe form of human malaria is caused by the parasite Plasmodium falciparum. The second messenger cAMP has been shown to be important for the parasite's ability to infect the host's liver, but its role during parasite growth inside erythrocytes,
Eric Salazar, Erin M Bank, Nicole Ramsey, Kenneth C Hess, Kirk W Deitsch, Lonny R Levin, Jochen Buck   +6 more
doaj   +1 more source

Induction of RAGE shedding by activation of G protein-coupled receptors. [PDF]

PLoS ONE, 2012
The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease.
Verena V Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina   +3 more
doaj   +1 more source