Results 91 to 100 of about 30,280 (221)
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
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Identification of Small Molecule Inhibitors Selective for Type 1 Adenylyl Cyclase
The FASEB Journal, 2015 Adenylyl cyclases (ACs) are important integrators of signaling through G protein‐coupled receptors. There are nine isoforms of membrane‐bound ACs that have unique regulatory properties and expression patterns. Adenylyl cyclase 1 (AC1) belongs to a group of ACs that are stimulated by calcium in a calmodulin‐dependent manner.
Tarsis Brust, Val Watts
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Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain [PDF]
Neuropsychopharmacology, 2017 Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic ...
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Differential Modulation of GABAA Receptors Underlies Postsynaptic Depolarization- and Purinoceptor-Mediated Enhancement of Cerebellar Inhibitory Transmission: A Non-Stationary Fluctuation Analysis Study. [PDF]
PLoS ONE, 2016 Cerebellar GABAergic inhibitory transmission between interneurons and Purkinje cells (PCs) undergoes a long-lasting enhancement following different stimulations, such as brief depolarization or activation of purinergic receptors of postsynaptic PCs.
Yumie Ono +2 more
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Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]
, 2003 Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B. +5 more
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A review on antidepressant effect of medicinal plants [PDF]
, 2017 Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of ...
Rabie, S., Rabiei, Z.
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Toxins, 2012 Edema Factor (EF) is a component of <em>Bacillus anthracis</em> toxin essential for virulence. Its adenylyl cyclase activity is induced by complexation with the ubiquitous eukaryotic cellular protein, calmodulin (CaM).
Arnaud Blondel +4 more
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Experimental Biology and Medicine, 1977 SummaryAdenylyl cyclase activities were measured in mucosal 600g paniculate preparations from the fundic stomach of rats, dogs, rabbits and guinea pigs. In vitro incubation with prostaglandin E1 and NaF activated the enzyme in all species. Penta-gastrin and carbachol were ineffective activators in any of the species tested. Hista-mine activated mucosal
W J, Thompson, E D, Jacobson
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Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons
Molecular Pain, 2007 Prostaglandin E2 (PGE2) is a well-known inflammatory mediator that enhances the excitability of DRG neurons. Homomeric P2X3 and heteromeric P2X2/3 receptors are abundantly expressed in dorsal root ganglia (DRG) neurons and participate in the transmission
Huang Li-Yen +2 more
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