Results 101 to 110 of about 30,280 (221)

Synthesis and Biological Study of Adenylyl Cyclase Inhibitors

, 2014
Adenylyl cyclases (AC) is a critical family of enzymes which modulates the dynamic cellular level of cAMP, cyclic adenosine monophosphate. The study of cAMP showed that it is indispensable for the signal transduction cascades during many physiological processes, such as immune responses and metabolism which highly relate to cancers. Previous studies of
Sun, Siyuan, Ye, Zhishi, Dai, Mingji
openaire   +1 more source

Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability

Scientific Reports, 2017
Prostacyclin (PGI2) modulates platelet activation to regulate haemostasis. Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation.
M. Z. Yusuf, Z. Raslan, L. Atkinson, A. Aburima, S. G. Thomas, K. M. Naseem, S. D. J. Calaminus   +6 more
doaj   +1 more source

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]

, 2010
Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália, Chao, Moses V., Pereira, Daniela B., Ribeiro, Joaquim A., Sebastião, Ana M, Sousa, Vasco C.   +5 more
core   +1 more source

Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

, 2022
Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela J. Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A.B. Burton   +8 more
openalex   +1 more source

Protein kinase A governs oxidative phosphorylation kinetics and oxidant emitting potential at complex I

Frontiers in Physiology, 2015
The mitochondrial electron transport system (ETS) is responsible for setting and maintaining both the energy and redox charges throughout the cell. Reversible phosphorylation of mitochondrial proteins, particularly via the soluble adenylyl cyclase (sAC)/
Daniel Stephen Lark, Lauren Rose Reese, Terence E Ryan, Maria J. Torres, Cody D. Smith, Chien-Te eLin, P. Darrell eNeufer   +6 more
doaj   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia, Dardis, Andrea, DE STEFANO, Maria Egle, Dragotto, Jessica, Erickson, Robert P., Fiorenza, Maria Teresa, Mangia, Franco, Zampieri, Stefania   +7 more
core   +1 more source

Psychostimulant Drugs and Neuroplasticity

Pharmaceuticals, 2011
Drugs of abuse induce plastic changes in the brain that seem to underlie addictive phenomena. These plastic changes can be structural (morphological) or synaptic (biochemical), and most of them take place in the mesolimbic and mesostriatal circuits ...
Emilio Fernandez-Espejo, Nieves Rodriguez-Espinosa   +1 more
doaj   +1 more source

The organisation and functions of local Ca²⁺ signals [PDF]

, 2001
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation.
Berridge, Michael J., Bootman, Martin D., Lipp, Peter   +2 more
core  

Activation of Adenosine Receptor A2A Increases HSC Proliferation and Inhibits Death and Senescence by Down-regulation of p53 and Rb

Frontiers in Pharmacology, 2014
Background & Aims: During fibrosis hepatic stellate cells (HSC) undergo activation, proliferation and senescence but the regulation of these important processes is poorly understood. The adenosine A2A receptor (A2A) is known to be present on HSC, and its
Md. Kaimul eAhsan, Wajahat eMehal
doaj   +1 more source