Results 111 to 120 of about 30,280 (221)

Glucose is a pH-dependent motor for sperm beat frequency during early activation.

PLoS ONE, 2012
To reach the egg in the ampulla, sperm have to travel along the female genital tract, thereby being dependent on external energy sources and substances to maintain and raise the flagellar beat. The vaginal fluid is rich in lactate, whereas in the uterine
Nadja Mannowetz, Petra M Wandernoth, Gunther Wennemuth   +2 more
doaj   +1 more source

The Role of the Sympathetic Nervous System in the Hypothermic Effect of d-Fenfluramine [PDF]

, 2002
Experiments in this dissertation were conducted to characterize the effects of d-fenfluramine on body temperature and the mechanisms by which d-fenfluramine alter body temperature.
Subramanian, Srividya
core   +1 more source

Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone

Brain Research Bulletin
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that mediate slow glutamatergic signal transduction and regulate cell excitability in the central nervous system.
Megumi Taketo
doaj   +1 more source

High throughput screening for chemical inhibitors of mammalian adenylyl cyclases expressed in fission yeast

, 2020
The poster describes our research to identify cell-permeable small molecule inhibitors of mammalian transmembrane adenylyl cyclases expressed in the fission yeast Schizosaccharomyces pombe.Video walkthrough of poster 581B describing HTSs to identify inhibitors of mammalian adenylyl cyclases expressed in the fission yeast Schizosaccharomyces pombe.
Hoffman, Charles, Huang, Sheng Xiang, Eberhard, Jeremy, Dessalines, Juliane, Ollila, Nicholas, Silva, Harrison, Dranchak, Patricia K., Inglese, James   +7 more
openaire   +1 more source

Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]

, 2009
Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós, Menyhárd, D.K., Náray-Szabó, Gábor   +2 more
core  

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Cytoplasmic Domain of Natriuretic Peptide Receptor C Constitutes Gi Activator Sequences That Inhibit Adenylyl Cyclase Activity [PDF]

, 2001
Matteo Pagano, Madhu B. Anand‐Srivastava   +1 more
openalex   +1 more source

Annexin A4 N‐terminal peptide inhibits adenylyl cyclase 5 and limits β‐adrenoceptor‐mediated prolongation of cardiac action potential [PDF]

, 2020
Alexander Heinick, Florentina Pluteanu, Christina Hermes, Andre Klemme, Manuel Domnik, Xenia Husser, Volker Gerke, Wilhelm Schmitz, Frank U. Müller   +8 more
openalex   +1 more source

Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets

Nature Communications
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide ...
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski   +38 more
doaj   +1 more source