Results 11 to 20 of about 58,275 (292)

A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance [PDF]

Frontiers in Pharmacology, 2022
Among the ten different adenylyl cyclase isoforms, studies with knockout animals indicate that inhibition of AC1 can relieve pain and reduce behaviors linked to opioid dependence. We previously identified ST034307 as a selective inhibitor of AC1.
Gianna Giacoletti, Tatum Price, Lucas V. B. Hoelz, Abdulwhab Shremo Msdi, Samantha Cossin, Katerina Vazquez-Falto, Tácio V. Amorim Fernandes, Tácio V. Amorim Fernandes, Vinícius Santos de Pontes, Hongbing Wang, Nubia Boechat, Adwoa Nornoo, Tarsis F. Brust   +12 more
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A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance [PDF]

Archives of Oral Biology, 2021
This study aimed to investigate the antinociceptive effects of the selective adenylyl cyclase type 1 (AC1) inhibitor ST034307 on tooth movement nociception through orofacial nociceptive behavior tests and molecular examination.We placed fixed nickel-titanium alloy closed-coil springs around the incisors of male Sprague-Dawley rats to induce tooth ...
Gianna Giacoletti, Tatum Price, Lucas Villas Bôas Hoelz, Abdulwhab Shremo Msdi, Katerina Vazquez-Falto, Tácio Vinício Amorim Fernandes, Vinícius Santos de Pontes, Hongbing Wang, Núbia Boechat, Adwoa O. Nornoo, Tarsis F. Brust   +10 more
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Activation of Rat Gastric Mucosal Adenylyl Cyclase by Secretory Inhibitors

Gastroenterology, 1977
Prostaglandin (PG) E1, E2, A1, and A2 stimulated rat gastric corpus mucosal membrane adenylyl cyclase activity. PGE1 (Kalpha congruent to 8 muM) affected the maximum velocity but not the affinity of the enzyme for ATP and maximum PGE1 activation was not affected by histamine H1 or H2 receptor antagonists.
W J, Thompson, L K, Chang, G C, Rosenfeld, E D, Jacobson   +3 more
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Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase [PDF]

Journal of Ocular Pharmacology and Therapeutics, 2023
Purpose: We investigated whether a clinically used carbonic anhydrase inhibitor (CAIs) can modulate intraocular pressure (IOP) through soluble adenylyl cyclase (sAC) signaling. Methods: IOP was measured 1 h after topical treatment with brinzolamide, a topically applied and clinically used CAIs, using direct cannulation of the anterior chamber in sAC ...
Shakarr V. Wiggins, Ryan Schreiner, Jacob Ferreira, Alan D. Marmorstein, Lonny R. Levin, Jochen Buck   +5 more
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Protein Associated with Myc (PAM) Is a Potent Inhibitor of Adenylyl Cyclases [PDF]

Journal of Biological Chemistry, 2001
Using the yeast two-hybrid assay and the second of the two large cytosolic domains of type V adenylyl cyclase (ACV) as bait, we identified a small region (amino acids 1028-1231) in the protein associated with Myc (PAM) as an interaction site for ACV.
Klaus Scholich, Sandra Pierre, Tarun B. Patel   +2 more
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Discovery of Novel Adenylyl Cyclase Inhibitor by Cell-Based Screening

Biological and Pharmaceutical Bulletin, 2014
We screened 2400 compounds to find novel inhibitors of the adenylyl cyclase (AC)-protein kinase A (PKA)-cAMP response-element-binding protein (CREB) signaling pathway (AC/PKA/CREB pathway). Using a multistep cell-based screening system employing split luciferase technique, we narrowed down the candidates effectively from 2400 chemical compounds and ...
Hiroki, Mano, Tetsuya, Ishimoto, Takuya, Okada, Naoki, Toyooka, Hisashi, Mori   +4 more
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Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors. [PDF]

J Ocul Pharmacol Ther, 2017
Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.   +6 more
europepmc   +2 more sources

Rosmarinic Acid Present in Lepechinia floribunda and Lepechinia meyenii as a Potent Inhibitor of the Adenylyl Cyclase gNC1 from Giardia lamblia [PDF]

Plants
Giardiasis is a parasitosis caused by Giardia lamblia with significant epidemiological and clinical importance due to its high prevalence and pathogenicity.
Adolfo Zurita, Esteban Vega Hissi, Agostina Cianci Romero, Adela María Luján, Sofía Salido, Agustín Yaneff, Carlos Davio, Justo Cobo, María Cecilia Carpinella, Ricardo Daniel Enriz   +9 more
doaj   +2 more sources

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10)

ACS Medicinal Chemistry Letters, 2021
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for in vivo interrogation of sAC inhibition to assess its potential therapeutic applications. This work culminated in the identification
Makoto Fushimi, Hannes Buck, Melanie Balbach, Anna Gorovyy, Jacob Ferreira, Thomas Rossetti, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Efrat Finkin-Groner, Stacia Kargman, Mayako Michino, Michael A. Foley, Michael Miller, Nigel J. Liverton, David J. Huggins, Peter T. Meinke   +19 more
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Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.

PLoS ONE, 2008
BackgroundMammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases.
Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck   +5 more
doaj   +2 more sources