Results 201 to 210 of about 30,280 (221)

An Enigma of Brain Gasotransmitters: Hydrogen Sulfide and Depression. [PDF]

Neuromolecular Med
Pinna A, Kistowska J, Pałasz A.
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Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases

Biochemistry, 2004
Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a region homologous to protein kinases, followed by the C ...
Jaleel, Mahaboobi, Shenoy, Avinash R, Visweswariah, Sandhya S   +2 more
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Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 2015
Membrane-bound adenylyl cyclases constitute an interesting therapeutic target for various diseases that affect a large number of patients including asthma or congestive heart failure. Many inhibitors of adenylyl cyclases are competitive inhibitors at the ATP binding site and may, therefore, also interact with one or several of numerous ATP-binding ...
Karl-Norbert, Klotz, Sonja, Kachler
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Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain

Science Translational Medicine, 2011
In animal models, an adenylyl cyclase 1 inhibitor acts as an effective treatment for neuropathic pain, in part by acting on the anterior cingulate cortex.
Hansen, Wang, Hui, Xu, Long-Jun, Wu, Susan S, Kim, Tao, Chen, Kohei, Koga, Giannina, Descalzi, Bo, Gong, Kunjumon I, Vadakkan, Xuehan, Zhang, Bong-Kiun, Kaang, Min, Zhuo   +11 more
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The Cox-2-Specific Inhibitor Celecoxib Inhibits Adenylyl Cyclase

Inflammation, 2003
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known causes of acute renal insufficiency and gastropathy in patients with chronic inflammatory diseases. This action is presumed to result from nonselective inhibition of both constitutive and inducible forms of prostaglandin H synthases, also known as the cyclooxygenase enzymes (i.e., COX-1 amd ...
Shamsher S, Saini, Deborah L, Gessell-Lee, Johnny W, Peterson   +2 more
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Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor

Journal of Chemical Information and Modeling, 2017
Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that converts ATP into cyclic AMP (cAMP), an important second messenger molecule. Upregulation of AC2 is linked to cancers like pancreatic and small intestinal neuroendocrine tumors (NETs).
Neha Rana, Jason M. Conley, Monica Soto-Velasquez, Francisco León, Stephen J. Cutler, Val J. Watts, Markus A. Lill   +6 more
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Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis

Trends in Microbiology, 2012
Whooping cough is a very important medical problem that requires novel approaches for treatment. The disease is caused by Bordetella pertussis, with the calmodulin (CaM)-activated adenylyl cyclase (AC) toxin (also known as CyaA) being a major virulence factor.
Roland, Seifert, Stefan, Dove
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