Results 231 to 240 of about 30,514 (251)

Direct crosstalk between GPCRs and ion channels via G proteins. [PDF]

Exp Mol Med
Kim SH, Kim J, So I, Lee HH.
europepmc   +1 more source

ATP depletion in anthrax edema toxin pathogenesis. [PDF]

PLoS Pathog
Liu J, Cao Q, Ewing M, Zuo Z, Kennerdell JR, Finkel T, Leppla SH, Liu S.   +7 more
europepmc   +1 more source

Attention-deficit/hyperactivity disorder: insights, advances and challenges in research and practice. [PDF]

Postep Psychiatr Neurol
Prasad S, Kumminimana R.
europepmc   +1 more source

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The Cox-2-Specific Inhibitor Celecoxib Inhibits Adenylyl Cyclase

Inflammation, 2003
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known causes of acute renal insufficiency and gastropathy in patients with chronic inflammatory diseases. This action is presumed to result from nonselective inhibition of both constitutive and inducible forms of prostaglandin H synthases, also known as the cyclooxygenase enzymes (i.e., COX-1 amd ...
Shamsher S, Saini, Deborah L, Gessell-Lee, Johnny W, Peterson   +2 more
openaire   +2 more sources

Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 2015
Membrane-bound adenylyl cyclases constitute an interesting therapeutic target for various diseases that affect a large number of patients including asthma or congestive heart failure. Many inhibitors of adenylyl cyclases are competitive inhibitors at the ATP binding site and may, therefore, also interact with one or several of numerous ATP-binding ...
Karl-Norbert, Klotz, Sonja, Kachler
openaire   +2 more sources

Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis

Trends in Microbiology, 2012
Whooping cough is a very important medical problem that requires novel approaches for treatment. The disease is caused by Bordetella pertussis, with the calmodulin (CaM)-activated adenylyl cyclase (AC) toxin (also known as CyaA) being a major virulence factor.
Roland, Seifert, Stefan, Dove
openaire   +2 more sources

Identification of an Adenylyl Cyclase Inhibitor for Treating Neuropathic and Inflammatory Pain

Science Translational Medicine, 2011
In animal models, an adenylyl cyclase 1 inhibitor acts as an effective treatment for neuropathic pain, in part by acting on the anterior cingulate cortex.
Hansen, Wang, Hui, Xu, Long-Jun, Wu, Susan S, Kim, Tao, Chen, Kohei, Koga, Giannina, Descalzi, Bo, Gong, Kunjumon I, Vadakkan, Xuehan, Zhang, Bong-Kiun, Kaang, Min, Zhuo   +11 more
openaire   +2 more sources