Results 241 to 250 of about 30,514 (251)
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MANT-substituted guanine nucleotides: A novel class of potent adenylyl cyclase inhibitors
Life Sciences, 2003Mammals express nine membranous adenylyl cyclase (AC) isoforms (AC1-AC9), but the precise functions of AC isoforms are still incompletely understood. This situation is at least partially due to the paucity of potent and isoenzyme-specific AC inhibitors.
Andreas, Gille, Roland, Seifert
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ACS Medicinal Chemistry Letters, 2021
Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for in vivo interrogation of sAC inhibition to assess its potential therapeutic applications. This work culminated in the identification
Makoto Fushimi +19 more
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Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe successful efforts to design improved sAC inhibitors amenable for in vivo interrogation of sAC inhibition to assess its potential therapeutic applications. This work culminated in the identification
Makoto Fushimi +19 more
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Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor
Journal of Chemical Information and Modeling, 2017Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that converts ATP into cyclic AMP (cAMP), an important second messenger molecule. Upregulation of AC2 is linked to cancers like pancreatic and small intestinal neuroendocrine tumors (NETs).
Neha Rana +6 more
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European Journal of Pharmacology, 2006
The utility of morphine for the treatment of chronic pain is limited by the development of analgesic tolerance. Adenylyl cyclase (AC) superactivation, induced by chronic opioid agonist administration, is regarded as one of the molecular mechanisms leading to tolerance.
Xu, Yue +5 more
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The utility of morphine for the treatment of chronic pain is limited by the development of analgesic tolerance. Adenylyl cyclase (AC) superactivation, induced by chronic opioid agonist administration, is regarded as one of the molecular mechanisms leading to tolerance.
Xu, Yue +5 more
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Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors
2010Säugetiere exprimieren neun membranäre Adenylyl-Zyklasen (AC 1-9) für die Katalyse des wichtigen second messengers cAMP in der intrazelluären Signaltransduktion. Inhibitoren von AC1 und AC5 könnten nützliche Arzneistoffe für Neuroprotektion, Herzinsuffizienz und eine verlängerte Lebenserwartung darstellen.
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Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases.
Molecular Pharmacology, 1990Tissue levels of 3'-AMP were measured in several rat tissues and the sensitivities of the respective adenylyl cyclases were compared with respect to "P" site-mediated inhibition by 3'-AMP2'-deoxy-3'AMP (2'd3'-AMP), and 2',5'-dideoxyadenosine. IC50 values for these P site inhibitors of adenylyl cyclases varied widely among tissues, e.g., with skeletal ...
M, Bushfield, I, Shoshani, R A, Johnson
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ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Daniel, Levy +7 more
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Daniel, Levy +7 more
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G protein inhibitors unravel Gq-dependent adenylyl cyclase activation in CHO-M1 cells
2017Muscarinic acetylcholine receptors (mAChRs) belong to the family of G protein-coupled receptors (GPCRs). GPCR-induced signaling can be the result of the interplay between complex molecular events as several GPCRs can activate multiple different adaptor proteins.
T. Bödefeld +7 more
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Isoform Selectivity of Adenylyl Cyclase Inhibitors
The Journal of Pharmacology and Experimental Therapeutics, 2013openaire +1 more source
High-Throughput Screening Paradigm Identifying an Adenylyl Cyclase 2 Inhibitor
The Journal of Pharmacology and Experimental Therapeutics, 2013openaire +1 more source