Results 21 to 30 of about 30,514 (251)

Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases

Biochemistry, 2004
Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a region homologous to protein kinases, followed by the C ...
Mahaboobi Jaleel, Avinash R. Shenoy, Sandhya S. Visweswariah   +2 more
openalex   +3 more sources

Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model [PDF]

Molecular Pain, 2016
Background Cancer pain, especially the one caused by metastasis in bones, is a severe type of pain. Pain becomes chronic unless its causes and consequences are resolved. With improvements in cancer detection and survival among patients, pain has been considered as a great challenge because traditional therapies are partially effective in terms of ...
Wenbo Kang, Qi Yang, Yanyan Guo, Lu Wang, Dongsheng Wang, Qiang Cheng, Xiaoming Li, Jun Tang, Jianning Zhao, Gang Liu, Min Zhuo, Ming Zhao   +11 more
openalex   +3 more sources

Inhibitors of membranous adenylyl cyclases [PDF]

Trends in Pharmacological Sciences, 2012
Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)physiological roles. Consequently, there is substantial interest in the development of isoform-selective mAC inhibitors.
Roland, Seifert, Gerald H, Lushington, Tung-Chung, Mou, Andreas, Gille, Stephen R, Sprang   +4 more
openaire   +2 more sources

Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors. [PDF]

J Ocul Pharmacol Ther, 2017
To validate the increase in intraocular pressure (IOP) caused by soluble adenylyl cyclase (sAC) inhibitors and determine reasons behind variation in IOP measurements performed by tonometry.C57BL/6J mice were administered DMSO solubilized sAC inhibitors (KH7 or LRE-1) by intraperitoneal injection.
Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.   +6 more
europepmc   +4 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment [PDF]

Journal of Cardiac Failure, 2016
Pediatric heart failure (HF) patients have a suboptimal response to traditional HF medications, although phosphodiesterase-3 inhibition (PDE3i) has been used with greater success than in the adult HF population. We hypothesized that molecular alterations specific to children with HF and HF etiology may affect response to treatment.Adenylyl cyclase (AC)
Stephanie J. Nakano, Juliana Sucharov, Robert van Dusen, Mackenzie Cecil, Karin Nunley, Sean T. Wickers, Karimpur-Fard Anis, Brian L. Stauffer, Shelley D. Miyamoto, Carmen C. Sucharov   +9 more
openalex   +3 more sources

Exchange of Substrate and Inhibitor Specificities between Adenylyl and Guanylyl Cyclases [PDF]

Journal of Biological Chemistry, 1998
The active sites of guanylyl and adenylyl cyclases are closely related. The crystal structure of adenylyl cyclase and modeling studies suggest that specificity for ATP or GTP is dictated in part by a few amino acid residues, invariant in each family, that interact with the purine ring of the substrate.
Roger K. Sunahara, Annie Beuve, J.J.G. Tesmer, Stephen R. Sprang, David L. Garbers, Alfred G. Gilman   +5 more
openalex   +3 more sources

In Silico Prediction of Tyrosinase and Adenylyl Cyclase Inhibitors from Natural Compounds [PDF]

Natural Product Communications, 2014
Although many herbal medicines are effective in the treatment of hyperpigmentation, the potency of different constituents remains unknown. In this work, more than 20,000 herbal ingredients from 453 herbs were docked into the crystal structures of adenylyl cyclase and a human homology tyrosinase model using Surflex-Dock.
Pedro Fong, Henry H. Y. Tong, Chi M. Chao   +2 more
openalex   +3 more sources

Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization. [PDF]

PLoS ONE, 2011
The intracellular second messenger cyclic AMP (cAMP) is degraded by phosphodiesterases (PDE). The knowledge of individual families and subtypes of PDEs is considerable, but how the different PDEs collaborate in the cell to control a cAMP signal is still ...
Karina Matthiesen, Jacob Nielsen
doaj   +1 more source

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

eLife, 2023
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth.
Arun Devotta, Hugo Juraver-Geslin, Casey Griffin, Jean-Pierre Saint-Jeannet   +3 more
doaj   +1 more source