Attenuation of changes in Gi‐proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril [PDF]
Journal of Cellular and Molecular Medicine, 2003 AbstractCardiac dysfunction in animals with congestive heart failure due to myocardial infarction (MI) is known to be associated with a wide variety of defects in receptor and post‐receptor mechanisms. Since the heart function have been shown to be improved by treatment with different angiotensin converting enzyme (ACE) inhibitors, we examined the ...
Rajat Sethi +3 more
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Adenine Nucleoside 3′-Tetraphosphates Are Novel and Potent Inhibitors of Adenylyl Cyclases [PDF]
Journal of Biological Chemistry, 1998 2'-Deoxyadenosine 3'-tetraphosphate (2'-deoxy-3'-A4P) and 2', 5'-dideoxyadenosine 3'-tetraphosphate (2',5'-dideoxy-3'-A4P) were synthesized, and their effects were tested on crude and purified forms of native adenylyl cyclases isolated from brain. Syntheses combined the method of alkoxide activation with the use of tribromoethyl phosphoromorpholino ...
Laurent Désaubry, Roger A. Johnson
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Palladium-catalyzed regio- and stereoselective γ-arylation of tertiary allylic amines: identification of potent adenylyl cyclase inhibitors. [PDF]
Org Lett, 2015 Ye Z, Brust TF, Watts VJ, Dai M.
europepmc +2 more sources
β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator. [PDF]
PLoS ONEIntroductionβ-Nicotinamide adenine dinucleotide (β-NAD) is recognized as a sympathetic neurotransmitter that relaxes vascular and intestinal smooth muscle through purinergic receptor pathways. In the lung, β-NAD has been associated with anti-inflammatory
Innokentij Jurastow +12 more
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Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors [PDF]
, 2010 Säugetiere exprimieren neun membranäre Adenylyl-Zyklasen (AC 1-9) für die Katalyse des wichtigen second messengers cAMP in der intrazelluären Signaltransduktion. Inhibitoren von AC1 und AC5 könnten nützliche Arzneistoffe für Neuroprotektion, Herzinsuffizienz und eine verlängerte Lebenserwartung darstellen.
Jens Geduhn
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Isoform Selectivity of Adenylyl Cyclase Inhibitors and Identification of Novel Compounds
The FASEB Journal, 2013 Nine membrane‐bound adenylyl cyclase (AC) isoforms produce the 2nd messenger cyclic AMP (cAMP) in response to a wide‐range of stimuli. Reduction of AC activity has well documented benefits, including for heart disease and pain. These roles have inspired development of isoform selective AC inhibitors, a lack of which currently limits exploration and/or ...
Cameron S. Brand +4 more
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Journal of Biological Chemistry, 2003 2′(3′)-O-(N-Methylanthraniloyl)-(MANT)-substituted nucleotides are fluorescent and widely used for the kinetic analysis of enzymes and signaling proteins. We studied the effects of MANT-guanosine 5′-[γ-thio]triphosphate (MANT-GTPγS) and MANT-guanosine 5′-
Andreas Gille, Roland Seifert
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The Beta-1-Receptor Blocker Nebivolol Elicits Dilation of Cerebral Arteries by Reducing Smooth Muscle [Ca2+]i. [PDF]
PLoS ONE, 2016 Nebivolol is known to have beta-1 blocker activity, but it was also suggested that it elicits relaxation of the peripheral arteries in part via release of nitric oxide (NO).
Peter Cseplo +5 more
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Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]
Frontiers in Physiology, 2022 Frontiers Production Office
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Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism.
O.A. López-Canales +5 more
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