Results 31 to 40 of about 58,275 (292)

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.

Journal of Medicinal Chemistry, 2022
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas.
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, M. Balbach, N. Kaur, L. Levin, J. Buck, Maria Kehr, Sandrine Coquille, J. van den Heuvel, C. Steegborn, M. Fushimi, Efrat Finkin-Groner, Robert W. Myers, S. Kargman, N. Liverton, D. Huggins, P. Meinke   +18 more
semanticscholar   +1 more source

Testing the Efficacy and Toxicity of Adenylyl Cyclase Inhibitors against Enteric Pathogens Using In Vitro and In Vivo Models of Infection

Infection and Immunity, 2010
Scott T. Moen, Carla A. Blumentritt, Terry M. Slater, Shilpa D. Patel, Christopher B. Tutt, Maria E. Estrella‐Jimenez, Jennifer Pawlik, Laurie Sower, Vsevolod L. Popov, Catherine H. Schein, Scott R. Gilbertson, Johnny W. Peterson, Alfredo G. Torres   +12 more
openalex   +2 more sources

Inhibitors of membranous adenylyl cyclases [PDF]

Trends in Pharmacological Sciences, 2012
Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)physiological roles. Consequently, there is substantial interest in the development of isoform-selective mAC inhibitors.
Roland, Seifert, Gerald H, Lushington, Tung-Chung, Mou, Andreas, Gille, Stephen R, Sprang   +4 more
openaire   +2 more sources

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +1 more source

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

Nature Communications, 2023
Nearly half of all pregnancies are unintended; thus, existing family planning options are inadequate. For men, the only choices are condoms and vasectomy, and most current efforts to develop new contraceptives for men impact sperm development, meaning ...
M. Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, D. Huggins, C. Steegborn, Ileana C. Miranda, P. Meinke, J. Buck, L. Levin   +11 more
semanticscholar   +1 more source

Induction of RAGE shedding by activation of G protein-coupled receptors. [PDF]

PLoS ONE, 2012
The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease.
Verena V Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina   +3 more
doaj   +1 more source

Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms.

Physiological Reviews, 2021
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors.
K. Ostrom, J. E. Lavigne, Tarsis F. Brust, R. Seifert, C. Dessauer, V. Watts, R. Ostrom   +6 more
semanticscholar   +1 more source

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase [PDF]

Nature Chemical Biology, 2016
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally in independently regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP: G-protein-regulated transmembrane adenylyl cyclases and bicarbonate-, calcium- and ATP ...
Lavoisier Ramos-Espiritu, Silke Kleinboelting, Felipe A Navarrete, Antonio Alvau, Pablo E Visconti, Federica Valsecchi, Anatoly Starkov, Giovanni Manfredi, Hannes Buck, Carolina Adura, Jonathan H Zippin, Joop van den Heuvel, J Fraser Glickman, Clemens Steegborn, Lonny R Levin, Jochen Buck   +15 more
openaire   +3 more sources

Effects of trypsin, protease inhibitors and ethanol on corpus luteum adenylyl cyclase.

Biology of reproduction, 1979
J, Abramowitz, L, Birnbaumer
openaire   +3 more sources

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

bioRxiv, 2021
Soluble adenylyl cyclase (sAC: ADCY10) is essential for activating dormant sperm. Studies of freshly dissected mouse sperm identified sAC as needed for initiating capacitation and activating motility.
M. Balbach, Lubna Ghanem, Thomas Rossetti, N. Kaur, Carla Ritagliati, Jacob Ferreira, D. Krapf, L. Molina, C. Santi, J. N. Hansen, D. Wachten, M. Fushimi, P. Meinke, J. Buck, L. Levin   +14 more
semanticscholar   +1 more source