Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization. [PDF]
, 2019 Glaucoma is characterized by a progressive optic nerve degeneration and retinal ganglion cell loss, but the underlying biological basis for the accompanying neurodegeneration is not known.
Ahn, Sangphil +6 more
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Targeting TRPM3 as a potential therapeutic approach for autosomal dominant polycystic kidney disease
Scientific ReportsCystic diseases, especially autosomal dominant polycystic kidney disease (ADPKD; incidence approx. 1/1000), are a leading cause of renal failure, caused by appearance and growth of renal cysts that can lead to renal failure in middle age.
Hüseyin Gül, Jamie A. Davies
doaj +1 more source
Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]
, 2017 Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
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Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?
Drug Design, Development and Therapy, 2013 Annette J Theron,1,2 Helen C Steel,1 Gregory R Tintinger,1 Charles Feldman,3 Ronald Anderson1 1Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, 2Tshwane Academic ...
Theron AJ +4 more
doaj
Ciliary adenylyl cyclases control the Hedgehog pathway [PDF]
, 2015 Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
Herrera, Antonio +4 more
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CFTR Inhibitors Display Antiviral Activity against Herpes Simplex Virus
VirusesThe cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent Cl− channel, is closely associated with multiple pathogen infections, such as SARS-CoV-2. However, whether the function of the CFTR is involved in herpes simplex virus (HSV)
Ping Jiang +8 more
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Anchored phosphatases modulate glucose homeostasis. [PDF]
, 2012 Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo +12 more
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Neurobiology of Disease, 2019 Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and type ...
Ryan B. Griggs +14 more
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Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala [PDF]
, 2008 Emotionally arousing events are particularly well remembered. This effect is known to result from the release of stress hormones and activation of beta adrenoceptors in the amygdala. However, the underlying cellular mechanisms are not understood.
Crane, James W. +5 more
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Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase [PDF]
, 1990 Large deletion and small insertion mutations in the adenylyl cyclase gene of Saccharomyces cerevisiae were used to map regions required for activation by RAS protein in vitro.
Ballester, R. +5 more
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