Results 111 to 120 of about 2,050,017 (297)

Exploratory analysis of the relationships among different methods of assessing adherence and glycemic control in youth with type 1 diabetes mellitus [PDF]

, 2011
Objectives: The present study examined four methods of assessing diabetes adherence (self-report, diary measure, electronic monitoring, and provider rating) within a population of youth with Type I Diabetes Mellitus (T1DM).
Alemzadeh, Ramin, Kaugars, Astrida S., Kichler, Jessica C., Maglio, Kelly   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adherence to Parenteral Methotrexate Compared to Oral Route in Patients with Rheumatoid Arthritis

Advanced Medical Journal
Background and objectives: Rheumatoid arthritis is a chronic autoimmune inflammatory disease, which causes discomfort, swelling, stiffness, and eventual joint destruction.
Mariwan Ismail Othman, Ziad Shafeeq Al.Rawi   +1 more
doaj   +1 more source

Medicines adherence: Involving patients in decisions about prescribed medicines and supporting adherence [PDF]

, 2009
It is thought that between a third and a half of all medicines1 There are many causes of non-adherence but they fall into two overlapping categories: intentional and unintentional.
Benson, J., Blair, J., Bowser, A., Calvert, N., Clyne, W., Crome, P., Haddad, P., Hemingway, S., Horne, R., Johnson, S., Kelly, S., Kuntze, S., National Collaborating Centre for Primary Care, Neilson, J., Nunes, V., O'Flynn, N., Packam, B., Patel, Mahendra, Smithson, H., Steel, J.   +19 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Editorial: Digital Tools to Measure and Promote Medication Adherence

Frontiers in Medical Technology, 2021
Job F. M. van Boven, João A. Fonseca
doaj   +1 more source

Persistence and adherence to levodopa adjunct medications in elderly patients with Parkinson’s disease: a retrospective cohort study using a Japanese claims database

Frontiers in Neurology
ObjectiveWe investigated treatment persistence and adherence for levodopa adjunct medications and their relationship with demographic factors in Japanese patients with Parkinson’s disease (PD).MethodsThis longitudinal retrospective study used a Japanese ...
Masahiro Nagai, Michinori Koebis, Kotaro Sasaki, Chizuru Kobayashi, Kasumi Daidoji, Takayuki Ishida   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Examination of the Role of Religious and Psychosocial Factors in HIV Medication Adherence Rates [PDF]

, 2017
Optimal adherence to antiretroviral therapy (ART) is associated with favorable HIV outcomes, including higher CD4 cell counts, HIV virus suppression and a lower risk of HIV transmission.
Clayton-Jones, Dora L., Dalmida, Safiya George, Fleming, Terri, Grant, Mary Margaret, Holstad, Marcia McDonnell, Koenig, Harold C., McCoy, Katryna, Miller, Aretha, Mugoya, George, Thomas, Tami, Wirani, Menka Munira   +10 more
core   +1 more source