Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Journal of Infection in Developing Countries, 2017 Introduction: The severity of urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) is due to the expression of a wide spectrum of virulence genes. E.
Yandag Munkhdelger +4 more
doaj +1 more source
Journal of Animal Science and Technology, 2020 For efficient prevention and treatment of enteric colibacillosis, understanding about latest virulence factors and antimicrobial resistance of Escherichia coli is essentially needed. The aim of this
Kyung-Hyo Do, Jae-Won Byun, Wan-Kyu Lee
doaj +1 more source
Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelium engagement and toxin delivery [PDF]
, 2016 At present, there is no vaccine for enterotoxigenic Escherichia coli (ETEC), an important cause of diarrheal illness. Nevertheless, recent microbial pathogenesis studies have identified a number of molecules produced by ETEC that contribute to its ...
Bhullar, Kirandeep +7 more
core +2 more sources
Identification of the catalytic motif of the microbial ribosome inactivating cytotoxin colicin E3 [PDF]
, 2004 Colicin E3 is a cytotoxic ribonuclease that specifically cleaves 16S rRNA at the ribosomal A-site to abolish protein synthesis in sensitive Escherichia coli cells.
Bohm +30 more
core +2 more sources
Virulence-associated genes, resistance genes and adhesion and probiotic activity tested by a new screening method [PDF]
, 2013 We established an automated screening method to characterize adhesion of Escherichia coli to intestinal porcine epithelial cells (IPEC-J2) and their probiotic activity against infection by enteropathogenic E. coli (EPEC). 104 intestinal E.
Frömmel, Ulrike +13 more
core +1 more source
TosR-Mediated Regulation of Adhesins and Biofilm Formation in Uropathogenic
mSphere, 2018 Uropathogenic Escherichia coli strains utilize a variety of adherence factors that assist in colonization of the host urinary tract. TosA (type one secretion A) is a nonfimbrial adhesin that is predominately expressed during murine urinary tract ...
Courtney L. Luterbach +3 more
doaj +1 more source
Shiga toxin-producing Escherichia coli: Factors involved in virulence and cattle colonization [PDF]
, 2013 Shiga toxin-producing Escherichia coli (STEC) cause hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS) in humans. Outbreaks are linked to bovine food sources. STEC O157:H7 has been responsible for the most severe outbreaks worldwide.
Etcheverría, Analía Inés +1 more
core +2 more sources
Adhesive factor/rabbit 2, a new fimbrial adhesin and a virulence factor from Escherichia coli O103, a serogroup enteropathogenic for rabbits [PDF]
, 1997 Enteropathogenic Escherichia coli-like E. coli strains belonging to serovar O103:K-:H2 and rhamnose-negative biotypes are highly pathogenic diarrhea-inducing strains for weaned European rabbits.
Fiederling, Franck +3 more
core
Draft Genome Sequence of Lactobacillus fermentum Strain 3872 [PDF]
, 2013 This report describes a draft genome sequence of Lactobacillus fermentum strain 3872. The data revealed remarkable similarity to and dissimilarity with the published genome sequences of other strains of the species.
Abramov, Vyacheslav M +2 more
core +1 more source