FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens [PDF]
Antibiotics, 2020 Chaperone-usher fimbrial adhesins are powerful weapons against the uropathogens that allow the establishment of urinary tract infections (UTIs). As the antibiotic therapeutic strategy has become less effective in the treatment of uropathogen-related UTIs,
Payam Behzadi +2 more
exaly +7 more sources
Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles [PDF]
Frontiers in ImmunologyUrinary tract infections, caused primarily by uropathogenic E. coli, are a significant public health burden, affecting approximately 50% of women worldwide.
Rebecca S. Cole +21 more
doaj +3 more sources
The Novel Type 1 Fimbriae FimH Receptor Calreticulin Plays a Role in Salmonella Host Specificity
Frontiers in Cellular and Infection Microbiology, 2017 It was suggested that minor differences in the structure of FimH are most likely associated with differences in its adhesion specificities and may determine the tropism of various Salmonella serovars to different species and tissues.
Anna Kędzierska +2 more
exaly +3 more sources
A Multi-Epitope FimH-CsgA-OmpA-Based Vaccine Induces Broad Anti-Adhesion Activity and Protects Chickens Against Avian Pathogenic Escherichia coli O2 Challenge [PDF]
LifeAvian pathogenic Escherichia coli (APEC) causes substantial economic losses in the poultry industry, and vaccines capable of providing protection across diverse APEC strains remain needed. In this study, a FimH-CsgA-OmpA multiepitope fusion antigen (MEFA)
Jiayu Cui +12 more
doaj +2 more sources
Detection of fimH virulence gene in uropathogenic Escherichia coli Using PCR [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2020 Urinary tract infections (UTIs) are one of main health problems caused by many microorganisms, including uropathogenic Escherichia coli (UPEC). The virulence factors are important in colonization of UPEC, extra-intestinal survival, and creation of ...
Rawan Amer Fadhil
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Recurrent urinary tract infections (rUTI) are a serious disease associated with morbidities and mortality. Resistance to the standard of care antibiotics is now widespread because of the continued use of antibiotics among people who suffer from rUTI.
Courtney M. Starks +5 more
doaj +1 more source
DETECTION FIMH AND PAPG GENES OF ESCHERICHIA COLI AND KLEBSIELLA PNEUMONIA ISOLATED FROM GALLSTONE , URINE STONE AND GASTROINTESTINAL CANAL BY POLYMERASE CHAIN REACTION (PCR) . [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2013 During this work twenty six isolates of Escherichia coli were collected (12 from gallstones , 10 from urin stones and 4 from gastrointestinal canal) and 14 isolates of Klebsiella pneumonia (4 from gallstones , 6 from urine stones and 4 from ...
MUTHANA BADEEA FARHAN +2 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Antibiotic resistance among gram-negative bacteria continues to rise globally at an alarming rate. New vaccines that prevent bacterial infections and reduce antibiotic use could provide a potential solution to these problems.
Gary R. Eldridge +10 more
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Molecules, 2020 Urinary tract infections (UTIs) are mainly caused by uropathogenic Escherichia coli (UPEC). Acute and recurrent UTIs are commonly treated with antibiotics, the efficacy of which is limited by the emergence of antibiotic resistant strains.
Daniela Scribano +7 more
doaj +1 more source
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.
PLoS Pathogens, 2021 Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitations ...
Lisa K McLellan +12 more
doaj +1 more source