Results 11 to 20 of about 7,588 (203)
Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH [PDF]
Beilstein Journal of Organic Chemistry, 2018 Photoaffinity labeling is frequently employed for the investigation of ligand–receptor interactions in solution. We have employed an interdisciplinary methodology to achieve facile photolabeling of the lectin FimH, which is a bacterial protein, crucial ...
Femke Beiroth +5 more
doaj +5 more sources
Iranian Journal of Microbiology, 2012 Background and Objectives: Urinary tract infection (UTI) is one of the most common infections in the world. The majority of UTIs are caused by Uropathogenic Escherichia coli (UPEC) strains.
Karam Mr Asadi +3 more
doaj +4 more sources
En route to photoaffinity labeling of the bacterial lectin FimH [PDF]
Beilstein Journal of Organic Chemistry, 2010 Mannose-specific adhesion of Escherichia coli bacteria to cell surfaces, the cause of various infections, is mediated by a fimbrial lectin, called FimH.
Thisbe K. Lindhorst +3 more
doaj +4 more sources
Catch-bond mechanism of the bacterial adhesin FimH [PDF]
Nature Communications, 2016 Abstract Ligand–receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell–cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains. These pathogens attach to
Sauer, Maximilian M. +9 more
openaire +9 more sources
, 2011 Adhesion of bacteria to glycosylated cells and surfaces is largely facilitated through adhesive organells projecting from the bacterial surface, which are called fimbriae. The most important fimbriae in Escherichia coli and in most of the other enterobacteria are the type 1 fimbriae which mediate adhesion in an α-D-mannoside-specific manner. The lectin
null Thisbe K. Lindhorst
openaire +2 more sources
D-Mannoside FimH Inhibitors as Non-Antibiotic Alternatives for Uropathogenic Escherichia coli
Antibiotics, 2021 FimH is a type I fimbria of uropathogenic Escherichia coli (UPEC), recognized for its ability to adhere and infect epithelial urinary tissue. Due to its role in the virulence of UPEC, several therapeutic strategies have focused on the study of FimH ...
Alfredo Montes-Robledo +2 more
doaj +2 more sources
Target Selectivity of FimH Antagonists
Journal of Medicinal Chemistry, 2012 Mannose-based FimH antagonists are considered new therapeutics for the treatment of urinary tract infections (UTIs). They prevent the adhesion of uropathogenic Escherichia coli (UPEC) to urothelial cell surfaces triggered by the lectin FimH, which is located at the tip of bacterial type 1 pili.
Scharenberg M +3 more
openaire +4 more sources
Escherichia coli adhesion protein FimH exacerbates colitis via CD11b+CD103- dendritic cell activation [PDF]
Frontiers in Immunology, 2023 IntroductionImmune stimulators are used to improve vaccine efficiency; however, they are accompanied by various side effects. In previous studies, we reported that the Escherichia coli adhesion protein, FimH, induces immune activity; however, we did not ...
Wei Zhang +5 more
doaj +2 more sources
PLoS PathogensAdhesion of E. coli to the urinary tract epithelium is a critical step in establishing urinary tract infections. FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (
Natalie C Silmon de Monerri +22 more
doaj +2 more sources
PLoS Pathogens, 2013 Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC reference strain LF82 adheres to ileal enterocytes via the common type 1 pili adhesin FimH and recognizes CEACAM6 receptors abnormally ...
Nicolas Dreux +13 more
doaj +2 more sources