Results 31 to 40 of about 7,588 (203)
Frontiers in Immunology, 2023 BackgroundMacrophages are key effector cells of innate immunity and play a critical role in the immune balance of disease pathogenesis, especially in the tumor microenvironment.
Wei Zhang +5 more
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FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro
Pathogens, 2023 Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. The FimH adhesin subunit of type 1 pili plays a key role
Shelly Roselyn Van Eyssen +4 more
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Characterization of Phylogroups, Virulence Factors and Antimicrobial Resistance in Canine Pyometra-associated Escherichia coli. [PDF]
Vet Med SciThis study characterized 56 Escherichia coli isolates obtained from canine pyometra, which predominantly belonged to phylogroup B2 and harboured multiple virulence genes, with high multidrug resistance rates indicating potential clinical and zoonotic risks. ABSTRACT The presence of multidrug‐resistant extraintestinal pathogenic Escherichia coli (ExPEC)
Müştak İB +4 more
europepmc +2 more sources
In vitro and in vivo characterization of FimH antagonists for anti-adhesion therapy - an alternative therapeutic approach against urinary tract infection [PDF]
, 2014 Uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections (UTI), which is one of the most common infectious disease worldwide.
Abgottspon, Daniela
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Journal of Clinical and Translational Science, 2021 IMPACT: We are developing the 3D perfusion system for use with patient-derived bacteria to further characterize the mechanism behind bacterial-induced inflammation and cancer. OBJECTIVES/GOALS: We previously reported the adherent invasive E.
Rachel C Newsome +8 more
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Allosteric Coupling in the Bacterial Adhesive Protein FimH [PDF]
Journal of Biological Chemistry, 2013 The protein FimH is expressed by the majority of commensal and uropathogenic strains of Escherichia coli on the tips of type 1 fimbriae and mediates adhesion via a catch bond to its ligand mannose. Crystal structures of FimH show an allosteric conformational change, but it remains unclear whether all of the observed structural differences are part of ...
Victoria B, Rodriguez +5 more
openaire +2 more sources
Synthesis and evaluation of glycomimetic antagonists for the lectins DC-SIGN and FimH [PDF]
, 2014 Lectins are carbohydrate-binding proteins that are widely spread in nature and crucially involved in a multitude of biological processes. This thesis addresses the design of glycomimetic antagonists for the human lectin DC-SIGN (chapter 2) and the ...
Mayer, Katharina
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Antagonizing the adhesion of type 1 fimbriae - mediated Escherichia coli - a novel therapy for urinary tract infections [PDF]
, 2015 Urinary tract infections (UTIs), primarily caused by uropathogenic E. coli (UPEC), affect millions of people and account for significant morbidity and high medical costs.
Pang, Lijuan
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Molecular Characterization of theEscherichia coliFimH Adhesin [PDF]
The Journal of Infectious Diseases, 2001 Bacterial adherence mediated by fimbriae is an essential prerequisite for colonization of the urinary tract. Uropathogenic Escherichia coli express a number of different adhesive organelles, including P, type 1, S, and F1C fimbriae [1]. Type 1, or mannose-sensitive, fimbriae are produced by >80% of all uropathogenic E. coli.
Schembri, M. A. +3 more
openaire +5 more sources
, 2007 FimH is the tip adhesin of mannose-specific type 1 fimbriae of Escherichia coli, which are critical to the pathogenesis of urinary tract infections. Point FimH mutations increasing monomannose (1M)-specific uro-epithelial adhesion are commonly found in ...
Chesnokova, Veronika +14 more
core +3 more sources