Results 31 to 40 of about 6,718 (165)

In pursuit of a novel UTI treatment strategy - an "in silico" study of the FimH adhesin [PDF]

, 2013
Carbohydrate-binding proteins (particularly lectins) are frequent targets of present pharmaceutical research. While of high priority due to their involvement in an array of pathophysiological events, these systems (along with their saccharidic ligands)
Zalewski, Adam
core   +1 more source

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function

Computational and Structural Biotechnology Journal, 2022
The binding of the type 1 fimbrial adhesin FimH to mannosylated receptors is allosterically regulated to enhance the fitness of uropathogenic Escherichia coli (UPEC) during urinary tract infection (UTI).
Jilong Qin, Katie A. Wilson, Sohinee Sarkar, Begoña Heras, Megan L. O'Mara, Makrina Totsika   +5 more
doaj   +1 more source

Molecular Detection of Type 1 Fimbriae-Encoding Gene (fimH) in Uropathogenic Escherichia coli Strains Isolated from Outpatients with Urinary Tract Infection [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objective: Urinary Tract Infection (UTI) is one of the most common infections in all age groups. The majority of these infections are caused by Uropathogenic Escherichia coli (UPEC) strains. Colonization, attachment to uroepithelium, and the
Nemat Shams, Amin Jaydari
doaj   +2 more sources

Diagnosis of postpartum endometritis in dairy cows using a portable endovideo-vaginoscope with pcr confirmation [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Endometritis remains a major cause of reduced reproductive efficiency in dairy cattle, necessitating practical methods for clinical detection and identification of bacterial etiology under farm conditions.
Dauletbek MURATBAYEV, Yernur SAKHARIYEV, Shynar TASTEMIROVA, Isatai JAKUPOV, Ainur AKHMADIYEVA, Cihan KACAR, Yavuz OZTURKLER   +6 more
doaj   +1 more source

Comparative Study of Aryl O-, C-, and S-Mannopyranosides as Potential Adhesion Inhibitors toward Uropathogenic E. coli FimH

Molecules, 2019
A set of three mannopyranoside possessing identical 1,1′-biphenyl glycosidic pharmacophore but different aglyconic atoms were synthesized using either a palladium-catalyzed Heck cross coupling reaction or a metathesis reaction between their ...
Leila Mousavifar, Gérard Vergoten, Guillaume Charron, René Roy   +3 more
doaj   +1 more source

Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells

Vaccines, 2023
The development of lactic acid bacteria as mucosal vaccine vectors requires the identification of robust mucosal adjuvants to increase vaccine effectiveness. The E.
Allison C. Vilander, Kimberly Shelton, Alora LaVoy, Gregg A. Dean   +3 more
doaj   +1 more source

Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection

Journal of Microbiology, Immunology and Infection, 2022
Background: FimH adhesin is proposed to enhance Escherichia coli kidney infection by acting with PapGII adhesin, but genetic epidemiology study and animal study have not been widely conducted to confirm this hypothesis.
Chin-Chung Tseng, Wei-Hung Lin, An-Bang Wu, Ming-Cheng Wang, Ching-Hao Teng, Jiunn-Jong Wu   +5 more
doaj   +1 more source

Frequency of fimH, papC, and aer in E. coli Strains Isolated from Patients with Urinary Tract Infection, and their Antibiotic Resistance Pattern

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: E. coli is the predominant causes of urinary tract infection. Several virulence factors for bacterial infections in the urinary tract are required.
Zahra Abdolahzadeh, Akram Astani, Ahmad Mosadegh, Saeede Sadat Hosseini Mohammad Abadi, Mahmoud Vakili   +4 more
doaj  

Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Ty21a to the Bladder Epithelium

Bladder Cancer, 2021
BACKGROUND: Bladder cancer is the ninth most common cancer in men. 70% of these tumors are classified as non-muscle invasive bladder cancer and those patients receive 6 intravesical instillations with Mycobacterium bovis BCG after transurethral resection.
Maroeska J. Burggraaf, Lisette Waanders, Mariska Verlaan, Janneke Maaskant, Diane Houben, Joen Luirink, Wilbert Bitter, Coen Kuijl, Carla F.M. Molthoff   +8 more
doaj   +1 more source

Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists

Pharmaceutics, 2023
Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs.
Leila Mousavifar, Meysam Sarshar, Clarisse Bridot, Daniela Scribano, Cecilia Ambrosi, Anna Teresa Palamara, Gérard Vergoten, Benoît Roubinet, Ludovic Landemarre, Julie Bouckaert, René Roy   +10 more
doaj   +1 more source