Results 51 to 60 of about 6,718 (165)

Flagella, Type I Fimbriae and Curli of Uropathogenic Escherichia coli Promote the Release of Proinflammatory Cytokines in a Coculture System

Microorganisms, 2021
Background. Urinary tract infections (UTIs) are a public health problem in Mexico, and uropathogenic Escherichia coli (UPEC) is one of the main etiological agents. Flagella, type I fimbriae, and curli promote the ability of these bacteria to successfully
Rubí Vega-Hernández, Sara A. Ochoa, Ricardo Valle-Rios, Gustavo A. Jaimes-Ortega, José Arellano-Galindo, Gerardo Aparicio-Ozores, José Antonio Ibarra, Rigoberto Hernández-Castro, Ariadnna Cruz-Córdova, Juan Xicohtencatl-Cortes   +9 more
doaj   +1 more source

Target Selectivity of FimH Antagonists

, 2016
Mannose-based FimH antagonists are considered new therapeutics for the treatment of urinary tract infections (UTIs). They prevent the adhesion of uropathogenic Escherichia coli (UPEC) to urothelial cell surfaces triggered by the lectin FimH, which is ...
Oliver Schwardt (1637842), Beat Ernst (1637845), Meike Scharenberg (1637833), Said Rabbani (1637803)   +3 more
core   +1 more source

Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease

Microbiome, 2021
Background An Escherichia coli (E. coli) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC), was shown to be prevalent in up to half the individuals with Crohn’s Disease (CD), suggesting ...
Grégoire Chevalier, Arnaud Laveissière, Guillaume Desachy, Nicolas Barnich, Adeline Sivignon, Marc Maresca, Cendrine Nicoletti, Eric Di Pasquale, Margarita Martinez-Medina, Kenneth William Simpson, Vijay Yajnik, Harry Sokol, MOBIDIC Study Investigators, Jonathan Plassais, Francesco Strozzi, Alessandra Cervino, Rachel Morra, Christophe Bonny   +17 more
doaj   +1 more source

Effect of antibody binding on FimH conformation.

, 2015
Binding of the active state-specific mAb21 (biotinylated) to fimbrial FimHwt (A) and FimHA188D (B) after pre-treatment with 1% (52 mM) mannose, 50 μg/ml mAb475, or mAb926.
Della Friend (463416), John P. Sumida (346286), Dagmara I. Kisiela (159496), Xue-Ru Wu (37168), Wendy E. Thomas (126495), Shivani Gupta (140138), Gianluca Interlandi (126489), Victoria B. Rodriguez (738918), Aachal Jalan (738917), Evgeni V. Sokurenko (158563), Yan Liu (25061), Veronika Tchesnokova (159514), Hovhannes Avagyan (738916), Roland K. Strong (106410)   +13 more
core   +1 more source

Unraveling the Potential of MXenes in Electrochemical Sensing: Mechanistic Insight, Design Principles, and Analytical Applications

Small Science, Volume 6, Issue 5, May 2026.
This review comprehensively examines recent progress in MXene‐based electrochemical sensors for the detection of glucose, hydrogen peroxide, heavy metals, pesticides, nitrites, phenolic pollutants, neurotransmitters, biomarkers, and pharmaceutical compounds.
Hichem Moulahoum, Faezeh Ghorbanizamani, Tomáš Kovářík, Kalim Deshmukh   +3 more
wiley   +1 more source

Type 1 fimbriae are important factors limiting the dissemination and colonization of mice by Salmonella Enteritidis and contribute to the induction of intestinal inflammation during Salmonella invasion

Frontiers in Microbiology, 2015
We have recently shown that S. Gallinarum type 1 fimbriae with endogenous mannose-resistant (MR) variant of the FimH protein increase systemic dissemination of S. Gallinarum and colonization of internal organs in comparison to the S.
Marta eKuźmińska-Bajor, Krzysztof eGrzymajło, Maciej eUgorski, Maciej eUgorski   +3 more
doaj   +1 more source

Molecular typing of uropathogenic isolated from Korean children with urinary tract infection [PDF]

Korean Journal of Pediatrics, 2015
PurposeWe investigated the molecular types of uropathogenic Escherichia coli (UPEC) by using conventional phylogrouping, multilocus sequence typing (MLST), and fimH genotyping.MethodsSamples of patients younger than 18 years of age were collected from ...
Ki Wook Yun, Do Soo Kim, Wonyong Kim, In Seok Lim   +3 more
doaj   +1 more source

Motor‐Assisted Co‐Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport

BioEssays, Volume 48, Issue 3, March 2026.
Directional intracellular cargo transport is traditionally attributed to motor stepping along stationary microtubule (MT) tracks. We propose a complementary mechanism of cargo co‐migration with moving MTs. This mode requires cargo–MT tethering and directed MT motion.
Chuying Zhou, Mineko Kengaku
wiley   +1 more source

Bacterial Lectin FimH and Its Aggregation Hot-Spots: An Alternative Strategy against Uropathogenic Escherichia coli

Pharmaceutics, 2023
Type I fimbriae are the main adhesive organelles of uropathogenic Escherichia coli (UPEC), consisting of four different subunits. Their component with the most important role in establishing bacterial infections is the FimH adhesin located at the ...
Georgia I. Nasi, Konstantina I. Georgakopoulou, Marilena K. Theodoropoulou, Nikos C. Papandreou, Evangelia D. Chrysina, Paraskevi L. Tsiolaki, Vassiliki A. Iconomidou   +6 more
doaj   +1 more source

Emergence, Challenges, and Opportunities for Chiral Nanocellulose Assemblies in Tissue Engineering and Wound Healing

Small Structures, Volume 7, Issue 3, March 2026.
This review explores chiral nanomaterials for tissue engineering and wound healing, specifically focusing on the potential of nanocellulose. The inherent chirality of nanocelluloses and their assemblies enables the creation of biomimetic scaffolds with unique biological interactions. Chiral nematic self‐assembly of cellulose nanocrystals, in particular,
Mahboubeh Nabavinia, Hossein Khanjanzadeh, Asier R. Muguruza, Anna Roig, Erlantz Lizundia, Justin O. Zoppe   +5 more
wiley   +1 more source