Results 71 to 80 of about 6,718 (165)

Bacterial persistence and IL-1β secretion by colonic mucosa of CEABAC10 mice according to FimH sequence.

, 2013
(A) Quantification of LF82-ΔfimH/fimHLF82 (black square), LF82-ΔfimH/fimH7082 (white circle), LF82-ΔfimH/fimHK12 (white square) and LF82-ΔfimH/fimHLF28 (white triangle) bacteria in the feces of CEABAC10 mice infected with 109 bacteria on day 3 post ...
Jérémy Denizot (209615), Arlette Darfeuille-Michaud (112082), Margarita Martinez-Medina (277062), Alexander Mellmann (72273), Richard Bonnet (241637), Nicolas Barnich (277067), Nicolas Dreux (277061), Dagmara Kisiela (277064), Evgeni Sokurenko (277065), Sujay Chattopadhyay (158532), Jean-Frédéric Colombel (108372), Christel Neut (241629), Corinne Gower-Rousseau (277066), Maria Billig (277063)   +13 more
core   +1 more source

Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

IUCrJ, 2016
Selective inhibitors of the type 1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against Escherichia coli infections such as urinary-tract infections.
Jerome de Ruyck, Marc F. Lensink, Julie Bouckaert   +2 more
doaj   +1 more source

A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin

Molecules, 2018
The fimbrial lectin FimH from uro- and enteropathogenic Escherichia coli binds with nanomolar affinity to oligomannose glycans exposing Manα1,3Man dimannosides at their non-reducing end, but only with micromolar affinities to Manα1,2Man ...
Tetiana Dumych, Clarisse Bridot, Sébastien G. Gouin, Marc F. Lensink, Solomiya Paryzhak, Sabine Szunerits, Ralf Blossey, Rostyslav Bilyy, Julie Bouckaert, Eva-Maria Krammer   +9 more
doaj   +1 more source

Recurrent Urinary Tract Infection Caused by Multidrug‐Resistant Klebsiella pneumoniae: A Case Report

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Klebsiella pneumoniae is the second most common cause of urinary tract infection (UTI) in most populations; however, few cases of recurrent UTI (rUTI) have been described. In this report, we described a patient who experienced 18 episodes of community‐acquired rUTI caused by extended‐spectrum β‐lactamase (ESBL)–producing and multidrug‐resistant (MDR) K.
Adriano Souza Santos Monteiro, Vívian Santos Galvão, Camila Maria Piñeiro Silva, Soraia Machado Cordeiro, Joice Neves Reis, Priya Gusain   +5 more
wiley   +1 more source

Dimeric and trimeric fusion proteins generated with fimbrial adhesins of uropathogenic Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2016
Urinary tract infections (UTIs) are associated with high rates of morbidity and mortality worldwide, and uropathogenic Escherichia coli (UPEC) is the main etiologic agent.
Víctor Manuel Luna-Pineda, Juan Pablo Reyes-Grajeda, Ariadnna Cruz-Córdova, Zeus Saldana, Sara A. Ochoa, Ma. del Carmen Maldonado-Bernal, Vicenta Cazares-Dominguez, José Arellano-Galindo, Leticia Moreno-Fierros, Rigoberto Hernandez-Castro, Juan Xicohtencatl-Cortes   +10 more
doaj   +1 more source

Unravelling the Pathotype, Biofilm, Virulome and Resistome Profile of MultiDrug‐Resistant Bacteria Isolated From Cattle Faeces Using Whole Genome Sequence Analysis

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
The high mortality and morbidity resulting from diarrhoeal cases worldwide are associated with the increasing incidence of antimicrobial resistance (AMR) and represent a serious public health concern. Cattle are a major reservoir of AMR organisms, and faecal shedding may facilitate their transmission into the food chain.
Tesleem Olatunde Abolarinwa, Daniel Jesuwenu Ajose, Bukola Opeyemi Oluwarinde, Akamu Jude Ewunkem, Peter Kotsoana Montso, Jean Engohang-Ndong, Todd Riley Callaway, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba, Shibiao Wan   +10 more
wiley   +1 more source

In silico Study of Toll-Like Receptor 4 Binding Site of FimH from Uropathogenic Escherichia coli

Journal of Medical Microbiology and Infectious Diseases, 2014
Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and
Mehri Habibi, Mohammad Reza Asadi Karam, Saeid Bouzari   +2 more
doaj  

Targeting Dynamical Binding Processes in the Design of Non-Antibiotic Anti-Adhesives by Molecular Simulation—The Example of FimH

Molecules, 2018
Located at the tip of type I fimbria of Escherichia coli, the bacterial adhesin FimH is responsible for the attachment of the bacteria to the (human) host by specifically binding to highly-mannosylated glycoproteins located on the exterior of the host ...
Eva-Maria Krammer, Jerome de Ruyck, Goedele Roos, Julie Bouckaert, Marc F. Lensink   +4 more
doaj   +1 more source

Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?

, 2017
Frequent antibiotic treatment of urinary tract infections has resulted in the emergence of antimicrobial resistance, necessitating alternative treatment options.
Kleeb, Simon, Rabbani, Said, Schwardt, Oliver, Sager, Christoph P., Beat Ernst, Oliver Schwardt, Mayer, Katharina, Christoph P. Sager, Said Rabbani, Simon Kleeb, Ernst, Beat, Deniz Eris, Katharina Mayer, Eris, Deniz   +13 more
core   +1 more source

Genomic and Pathogenic Characterization of an Extensively Drug‐Resistant Avian Pathogenic Escherichia coli Strain

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Extensively drug‐resistant (XDR) avian pathogenic Escherichia coli (APEC) poses a global threat to poultry and public health. In this study, we isolated an APEC strain, SDLYRA415, from broilers in Shandong, China, during an outbreak with ~20% mortality.
Weishi Ni, Lijuan Chen, Hao Chen, Kejing Wang, Lumin Yu, Xinglin Zhang, Peikun Wang, Ganwu Li   +7 more
wiley   +1 more source