Results 71 to 80 of about 7,588 (203)

Molecular typing of uropathogenic isolated from Korean children with urinary tract infection [PDF]

Korean Journal of Pediatrics, 2015
PurposeWe investigated the molecular types of uropathogenic Escherichia coli (UPEC) by using conventional phylogrouping, multilocus sequence typing (MLST), and fimH genotyping.MethodsSamples of patients younger than 18 years of age were collected from ...
Ki Wook Yun, Do Soo Kim, Wonyong Kim, In Seok Lim   +3 more
doaj   +1 more source

Potential Roles of Escherichia coli in IgA Nephropathy: Evidence, Mechanistic Hypotheses and Microbiota‐Targeted Strategies

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
Schematic diagram of the core pathogenic pathway by which E. coli drives IgAN.E. coli expansion in IgAN is driven by host, environmental and ecological factors, and promotes disease progression via two core pathways: LPS‐induced immune activation and pyroptosis, and metabolite‐mediated remote regulation, leading to Gd‐IgA1 overproduction, mesangial ...
Yuxin Liu, Xiaoxuan Ning, Yichen Liu, Zixian Yu, Jie Liu, Xiaoqin Xu, Jin Zhao, Shiren Sun   +7 more
wiley   +1 more source

Binding site plasticity regulation of the FimH catch-bond mechanism

Biophysical Journal, 2022
Abstract The bacterial fimbrial adhesin FimH is a remarkable and well-studied catch-bond protein found at the tip of E. coli type 1 pili, which allows pathogenic strains involved in urinary tract infections to bind high-mannose glycans exposed on human epithelia.
Languin-Cattoën, Olivier, Sterpone, Fabio, Stirnemann, Guillaume   +2 more
openaire   +3 more sources

Artificial Catch Bonds: From Molecular Design to Network Mechanics

ChemSystemsChem, Volume 8, Issue 5, September 2026.
Catch bonds strengthen rather than weaken under force. This review follows the discovery and development of our understanding of this counterintuitive phenomenon, from the molecular mechanisms that produce it to the design rules for engineering it in DNA, proteins, and polymers, and on to the collective network mechanics enabling materials that stiffen
Hengfeng Jiang, Micah Yang, Isaac T. S. Li   +2 more
wiley   +1 more source

Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation

Proteins: Structure, Function, and Bioinformatics, 2020
Allostery governing two conformational states is one of the proposed mechanisms for catch-bond behavior in adhesion proteins. In FimH, a catch-bond protein expressed by pathogenic bacteria, separation of two domains disrupts inhibition by the pili domain.
Jenny Liu, Luis A. Nunes Amaral, Sinan Keten   +2 more
openaire   +3 more sources

Identification of Potential Vaccine Strains of Escherichia coli Isolates From Diarrhoeic Calves

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study aimed to identify vaccine candidate Escherichia coli strains isolated from diarrheic calves. Faecal samples collected from 500 calves were analysed, and E. coli strains were isolated and characterized phenotypically and genotypically. Antibiotic resistance profiles, virulence‐associated genes and MLVA genotyping were used to select 20 ...
Yasemin Erdoğan, Ediz Kağan Özgen, Murat Özmen, Elif Karadeniz Pütür, Nebahat Polat, Ersan Pütür, Mücahit Harmancı, Ercan Atalay, Ahmet Temur, Meryem Güloğlu, Lütfullah Celep, Seyda Cengiz, Mehmet Cemal Adıgüzel, Cihan Öz, Timur Gülhan, Alper Çiftci, Erhan Çiftgül   +16 more
wiley   +1 more source

Target Selectivity of FimH Antagonists

, 2016
Mannose-based FimH antagonists are considered new therapeutics for the treatment of urinary tract infections (UTIs). They prevent the adhesion of uropathogenic Escherichia coli (UPEC) to urothelial cell surfaces triggered by the lectin FimH, which is ...
Oliver Schwardt (1637842), Beat Ernst (1637845), Meike Scharenberg (1637833), Said Rabbani (1637803)   +3 more
core   +1 more source

Adhesion of Escherichia coli under flow conditions reveals potential novel effects of FimH mutations [PDF]

, 2016
FimH-mediated adhesion of Escherichia coli to bladder epithelium is a prerequisite for urinary tract infections. FimH is also essential for blood-borne bacterial dissemination, but the mechanisms are poorly understood.
Aarestrup, F. M., Aarestrup, F M, T. Stockner, Schmidt Thøgersen, Mariane, Rees, A J, M. J. Ball, Thogersen, M. S., T. Feenstra, Kain, R, A. Peschel, Satchell, S. C., Wieser, E, Ball, M. J., E. Wieser, Feenstra, T, Thøgersen, M S, M. S. Thøgersen, F. M. Aarestrup, Peschel, A, Peschel, A., Kain, Renate, Aarestrup, Frank Møller, A. J. Rees, Brandes, R., Kain, R., R. Brandes, Wieser, E., J Ball, M, Satchell, S C, Brandes, R, Stockner, T, Feenstra, T., Rees, A. J., R. Kain, Stockner, T., S. C. Satchell   +35 more
core   +2 more sources

Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding

IUCrJ, 2017
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E.
Said Rabbani, Eva-Maria Krammer, Goedele Roos, Adam Zalewski, Roland Preston, Sameh Eid, Pascal Zihlmann, Martine Prévost, Marc F. Lensink, Andrew Thompson, Beat Ernst, Julie Bouckaert   +11 more
doaj   +1 more source

DataSheet_1_Escherichia coli adhesion protein FimH exacerbates colitis via CD11b+CD103- dendritic cell activation.docx

, 2023
IntroductionImmune stimulators are used to improve vaccine efficiency; however, they are accompanied by various side effects. In previous studies, we reported that the Escherichia coli adhesion protein, FimH, induces immune activity; however, we did not ...
Eun-Koung An (11383579), Peter C. W. Lee (6855368), Wei Zhang (405), Jun-O Jin (473261), Hae-Bin Park (7248422), So-Jung Kim (1644736)   +5 more
core   +1 more source