Results 61 to 70 of about 6,718 (165)

Prodruggability of Carbohydrates - Oral FimH Antagonists

, 2016
The bacterial lectin FimH is a promising therapeutic target for the nonantibiotic prevention and treatment of urinary tract infections. In this communication, an ester prodrug approach is described to achieve oral bioavailability for FimH antagonists. By
Kleeb, Simon, Schwardt, Oliver, Schönemann, Wojciech, Ernst, Beat, Dätwyler, Philipp   +4 more
core   +1 more source

DataSheet_1_Escherichia coli adhesion protein FimH exacerbates colitis via CD11b+CD103- dendritic cell activation.docx

, 2023
IntroductionImmune stimulators are used to improve vaccine efficiency; however, they are accompanied by various side effects. In previous studies, we reported that the Escherichia coli adhesion protein, FimH, induces immune activity; however, we did not ...
Eun-Koung An (11383579), Peter C. W. Lee (6855368), Wei Zhang (405), Jun-O Jin (473261), Hae-Bin Park (7248422), So-Jung Kim (1644736)   +5 more
core   +1 more source

How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Urinary tract infections possess substantial sex disparities in the incidence, immune response, and progression of infection. Some of these distinctions may be due to sexual dimorphism in mucosal barriers or sex differences in the initial immune response to infection.
Laura Ramirez Finn, Molly A. Ingersoll
wiley   +1 more source

Impact of FimH amino acid substitutions on AIEC adhesion ability.

, 2013
Cell-associated bacteria were quantified using undifferentiated (A) or differentiated (B) T84 cells after a 3 H infection period. WT represents the original AIEC LF82 reference strain and ΔfimH represents the LF82-ΔfimH isogenic mutant.
Jérémy Denizot (209615), Arlette Darfeuille-Michaud (112082), Margarita Martinez-Medina (277062), Alexander Mellmann (72273), Richard Bonnet (241637), Nicolas Barnich (277067), Nicolas Dreux (277061), Dagmara Kisiela (277064), Evgeni Sokurenko (277065), Sujay Chattopadhyay (158532), Jean-Frédéric Colombel (108372), Christel Neut (241629), Corinne Gower-Rousseau (277066), Maria Billig (277063)   +13 more
core   +1 more source

Development of a web tool for Escherichia coli subtyping based on fimH alleles:Running title: Development of E. coli fimH sub-typing web-tool [PDF]

, 2017
The aim of this study was to construct a valid publicly available method for in silico fimH sub-typing of Escherichia coli particularly suitable for differentiation of fine-resolution subgroups within clonal groups defined by standard multi-locus ...
Mariya Muradova, Rosa Allesøe, Martin C. F. Thomsen, Roer, Louise, Sujay Chattopadhyay, Frank Hansen, Muradova, Mariya, Thomsen, Martin Christen Frølund, Veronika Tchesnokova, Sokurenko, Evgeni, Ole Lund, Johanne Ahrenfeldt, Louise Roer, Ahrenfeldt, Johanne, Tchesnokova, Veronika, Allesøe, Rosa Lundbye, Chattopadhyay, Sujay, Hammerum, Anette Marie, Henrik Hasman, Anette M. Hammerum, Lund, Ole, Hansen, Frank, Hasman, Henrik, Evgeni Sokurenko   +23 more
core   +1 more source

Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding

IUCrJ, 2017
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E.
Said Rabbani, Eva-Maria Krammer, Goedele Roos, Adam Zalewski, Roland Preston, Sameh Eid, Pascal Zihlmann, Martine Prévost, Marc F. Lensink, Andrew Thompson, Beat Ernst, Julie Bouckaert   +11 more
doaj   +1 more source

Fluorescent Polymeric Materials for Bacterial Interaction and Detection

Macromolecular Chemistry and Physics, Volume 227, Issue 3, 16 February 2026.
This review highlights recent advances in fluorescent polymer design for bacterial interaction and detection. It examines key classes of functional polymers—including conjugated, glycopolymeric, and pH‐responsive systems—and the mechanisms they employ for bacterial recognition. Emphasis is placed on molecular design strategies that enhance selectivity,
Dilani Chathumalee, Stephen J. Butler, Amanda K. Pearce   +2 more
wiley   +1 more source

Exploring microorganism–host interactions: Emerging organoid models and analytical approaches

mLife, Volume 5, Issue 1, Page 17-34, February 2026.
Abstract Microorganisms play a vital role in human health through their interactions with the body. Studies of host–microbe mechanisms and interactions are crucial for advancing health management. Recently, the organoid‐based models have provided new platforms in this field.
Yue Shi, Min Xu, Yanhong Huang, Jing Qu, Shumin Liao, Yingzi Liu, Liang Li   +6 more
wiley   +1 more source

Biological characterization of the bacterial Adhesin FimH — implications for drug design [PDF]

, 2016
At first glance the pathogenesis of a urinary tract infection (UTI) may seem straightforward, but it involves layers of complexity that extend beyond the simple notion of bacterial binding to and subsequent invasion of urothelial host cells.
Eriṣ, Deniz
core   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source